Leukocyte-related parameters in older adults with metabolic syndrome

Yang, Xiao; Shen, Tian; Ma, Qiang; Sun, Hongpeng; Xu, Yong; Pan, Chen-Wei

doi:10.1007/s12020-020-02243-2

Cited by 25 publications

(23 citation statements)

References 46 publications

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“…All participants in our study were older, and some had chronic diseases. As shown in the studies by Jakob Zierk et al Yang et al (Yang et al, 2020), the leukocyte count was higher in males older than 50 years of age but lower in younger males, and the number of white blood cells increased in individuals with metabolic syndrome. The counts of leukocyte subsets, such as neutrophils, lymphocytes, and monocytes, increased with the BMI; however, the percentages of neutrophils and monocytes were inversely associated with BMI.…”

Section: Discussionmentioning

confidence: 83%

The population characteristics of the main leukocyte subsets and their association with chronic diseases in a community-dwelling population: a cross-sectional study

Chen

Wang

et al. 2021

Prim Health Care Res Dev

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Aim: To analyse the characteristics of the main leukocyte subsets and elucidate their distributions amongst the natural population. We wanted to determine whether leukocyte subsets are potential biomarkers to evaluate the risk of common chronic diseases. Background: The peripheral blood leukocyte count is a routine exam performed to detect pathogen infections. Recently, subsets of white blood cells and their homeostasis have shown strong associations with some chronic diseases. Therefore, studies aiming to discover whether the distribution of leukocyte counts and its subsets are useful for predicting health conditions are worthwhile. Methods: This cross-sectional study analysed 10 564 residents from the basic public health service project of the Health Checkup Program performed by the BaiYun Community Health Service Center. Data on demographic information, physical measurements, medical history, and routine blood examination parameters were collected using questionnaires and health check-ups. Restricted cubic spline incorporated into logistic regression analysis was performed to evaluate the association between subsets of leukocytes and common chronic diseases. Findings: The counts of leukocytes and their subsets in males were higher than those in females amongst all age groups, yet the percentages of lymphocytes and neutrophils did not present sex-specific differences. A low lymphocyte count and percentage were associated with old age. The neutrophil-to-lymphocyte ratio (NLR) in patients with hypertension was higher than that in the non-hypertensive population. The risk of NLR in the top quartiles was 1.17-fold higher than that in people in the lowest quartiles. Conclusions: The distributions of the white blood cell count and percentage were associated with age, sex, and body mass index (BMI). In addition to the immune barrier for pathogens, the NLR or monocyte-to-lymphocyte ratio (MLR) may be potentially used to indicate the risk of some chronic non-communicable diseases. Homeostasis of subsets of leukocytes may be an important biomarker for body health conditions.

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Section: Discussionmentioning

confidence: 83%

The population characteristics of the main leukocyte subsets and their association with chronic diseases in a community-dwelling population: a cross-sectional study

Chen

Wang

et al. 2021

Prim Health Care Res Dev

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“…The Weitang Geriatric Diseases Study is a communitybased study conducted in Weitang town located in Suzhou of China from August 2014 to January 2015. The detailed study protocol and some other findings have been reported in previous reports (7,8,9,10,11). In brief, invitation letters were sent to 6030 residents aged 60 years or older in the Weitang town based on official records.…”

Section: Study Populationmentioning

confidence: 99%

Platelet parameters in Chinese older adults with metabolic syndrome

Yang

Zhang

Ma³

et al. 2020

Endocrine Connections

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Purpose: We aimed to examine the associations of platelet parameters with the presence of metabolic syndrome in community-dwelling older Chinese adults. Methods: Study sample was from the Weitang Geriatric Diseases Study, which included 4338 individuals aged 60 years or above. The mean age of the participants was 68 years. Metabolic syndrome was defined based on the Adult Treatment Panel Ⅲ criteria. Platelet parameters were assessed using an automated hematology analyzer. Multiple logistic regression models were fitted to examine relationships between the platelet parameters and the presence of metabolic syndrome after adjusting for potential confounders. Results: The adjusted odds ratio (95% confidence interval) of metabolic syndrome for the highest quartile of platelet parameters (platelet count, mean platelet volume, plateletcrit, platelet distribution width, platelet larger cell ratio), when compared to the lowest quartile were 1.32 (1.06, 1.64), 1.00 (0.81, 1.24), 1.37 (1.10, 1.71),1.45 (1.14, 1.83), 1.11 (0.89, 1.39), respectively. Hypertension and diabetes modified the relationship between platelet distribution width and metabolic syndrome with the associations being significant in hypertensive and non-diabetic groups. The levels of platelet distribution width increased with the risk of metabolic syndrome in men but not in women. Conclusion: The levels of platelet count, plateletcrit and platelet distribution width increased in older adults with metabolic syndrome, suggesting that these parameters may be useful biomarkers for further risk appraisal of metabolic syndrome in aged population.

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“…Details of the baseline study have been described elsewhere. [15][16][17] In the baseline examinations, 6030 families who had an older adult aged 60 years or older based on local official records received an invitation letter, which explained the nature of the study and invited the older adults to participate. Exclusion criteria applied to those who had been living there shorter than six months, had migrated from the residing address, or had deceased.…”

Section: Study Design and Proceduresmentioning

confidence: 99%

<p>Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study</p>

Liu

Ma²,

et al. 2020

DMSO

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Background: There was a lack of studies focusing on older adults about the longitudinal association between metabolic syndrome (MetS) and hyperuricemia (HUA). We aimed to assess the association of baseline MetS and incident HUA among older Chinese adults, with a special focus on the associations between different combinations of MetS components and HUA. Methods: Data of 3247 Chinese adults aged 60 years or older included in a communitybased longitudinal cohort study were analyzed. Anthropometric examinations and collection of blood sample were conducted both at baseline and follow-up. HUA was defined as 7 mg/dl or above for men and 6 mg/dl or greater for women. MetS was assessed based on the National Cholesterol Education Program-Adult Treatment Panel III, and older adults with the presence of at least three of MetS components were considered as having MetS. Results: MetS and its components, including high blood pressure (BP), high body mass index, diabetes mellitus and high triglycerides, were significantly related to incident HUA. The association between high BP and incident HUA is strongest among the five MetS components. Among all combinations of MetS components, the group consisting of diabetes mellitus, high BP and high triglycerides had the highest odds for incident HUA (OR = 13.07, 95% CI = 4.95-34.54). Conclusion: MetS and its components, except for low high-density lipoprotein cholesterol, could increase the risk of HUA among community-dwelling older adults, and high BP may be the most important determinant.

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Leukocyte-related parameters in older adults with metabolic syndrome

Cited by 25 publications

References 46 publications

The population characteristics of the main leukocyte subsets and their association with chronic diseases in a community-dwelling population: a cross-sectional study

The population characteristics of the main leukocyte subsets and their association with chronic diseases in a community-dwelling population: a cross-sectional study

Platelet parameters in Chinese older adults with metabolic syndrome

<p>Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study</p>

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