Leukocyte transfusions revisited: Stem cell graft stimulation in graft failure

Taskinen, Mervi; Talvensaari, Kimmo; Hovi, Liisa; Vettenranta, Kim; Saarinen‐Pihkala, Ulla M.

doi:10.1002/pbc.21526

Cited by 3 publications

(2 citation statements)

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“…A previous study on paediatric patients showed possible role of buffy coat‐derived leukocytes in enhancing and sustaining myeloid engraftment in patients with SNS and delayed engraftment post‐allogeneic SCT. The authors hypothesised that the leukocyte concentrates might have provided allostimulatory trigger for engraftment (Taskinen et al , 2008). It was also possible that GT might have contributed to the earlier engraftment of cord blood stem cells in one of our patients.…”

Section: Discussionmentioning

confidence: 99%

Treatment of severe neutropenic sepsis with granulocyte transfusion in the current era – experience from an adult haematology unit in Singapore

Ang

Linn

2010

Transfusion Medicine

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Section: Discussionmentioning

confidence: 99%

Treatment of severe neutropenic sepsis with granulocyte transfusion in the current era – experience from an adult haematology unit in Singapore

Ang

Linn

2010

Transfusion Medicine

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“…Engraftment was observed in 15/22 patients at a median of 6 days after first GT. The authors hypothesized that beside the clearance of infection due to the neutrophils the lymphocytes might have acted as an allostimulatory trigger for engraftment [41].…”

Section: Therapeutic Granulocyte Transfusion In Childrenmentioning

confidence: 99%

Granulocyte transfusions in neutropenic patients: beneficial effects proven?

Peters

2009

Vox Sanguinis

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Despite the huge armamentarium of modern antibiotics and anti-fungals, infections remain life-threatening events in patients with profound neutropenia. For decades, the value of granulocyte transfusions (GT) has been explored and results are still not conclusive. However, it has been shown that GT increase peripheral blood neutrophil counts of recipients and lead to migration of functional neutrophils into inflamed tissues. A favourable increment of absolute neutrophil counts is observed after concentrates from technically up-to-date apherese from granulocyte-colony stimulating factor-stimulated donors. Most studies indicated a potential positive effect on infection elimination with a minimum cell content of GT (1.5-3 x 10(8)/kg recipient body weight). Although to date the beneficial effect of GT is not proven in prospective randomized trials, in specific situations GT is an option to treat infections along with antibiotics when there is profound neutropenia. However, these patients in critical situations need to be treated within carefully designed studies based on the best known methods for providing granulocyte concentrates in sufficient dose and frequency, standardized similar to other blood product transfusions. That includes definition of minimum cell content, maximum interval between apheresis and application, storage conditions, methods of donor stimulation according to patient's body weight and frequency of GT. This review considers the results of recent studies using GT from cytokine-stimulated donors and the consequences and effects in recipients and donors.

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Granulocyte Transfusion Therapy in Pediatric Patients After Hematopoietic Stem Cell Transplantation

Pham

Rogoza

Stotler

et al. 2012

Journal of Pediatric Hematology/Oncology

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Leukocyte transfusions revisited: Stem cell graft stimulation in graft failure

Abstract: LTX from random donors was associated with a rapid recovery of myeloid function in severely ill SCT patients. We speculate that allostimulation by LTX may have a role.

Cited by 3 publications

References 21 publications

Treatment of severe neutropenic sepsis with granulocyte transfusion in the current era – experience from an adult haematology unit in Singapore

Treatment of severe neutropenic sepsis with granulocyte transfusion in the current era – experience from an adult haematology unit in Singapore

Granulocyte transfusions in neutropenic patients: beneficial effects proven?

Granulocyte Transfusion Therapy in Pediatric Patients After Hematopoietic Stem Cell Transplantation

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