Leukocytes rolling and recruitment by endothelial cells: Hemorheological experiments and numerical simulations

Artoli, A.M.M.; Sequeira, Adélia; Silva-Herdade, Ana Santos; Saldanha, Carlota

doi:10.1016/j.jbiomech.2007.05.031

Cited by 21 publications

(21 citation statements)

References 28 publications

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“…Furthermore, as miniaturisation effects and molecular interactions can no longer be neglected, the flow physics can be dramatically different from the macroscale 26 . For example, surface area to volume ratio is dramatically increased 7 and the smaller length scales and velocities involved lead to very small Reynolds numbers (approximately 0.01 for leukocytes 27 ). Additional complexities arise from the fact that many physiological processes involve a strong coupling between the fluid and structural dynamics.…”

Section: Relevant Physics and Modelling Requirementsmentioning

confidence: 99%

“…Moreover, their dynamics, interactions, and adhesion to the vessel wall are crucial in immune response. This process has been the subject of a number of studies using the LBM 27,67 . Using a 3D shear-thinning LBM model to examine the local flow pattern around single and multiple WBCs, simulations revealed that recruitment of the WBC onto the vessel wall is supported by vortices generated from the 3D flow pattern.…”

Section: White Blood Cellsmentioning

confidence: 99%

“…Additionally, rolling of the WBC along the wall after recruitment is promoted via a torque generated by the flow over the WBC surface. Furthermore, it is thought that the shear stress induced by the rolling motion of the WBC over the endothelium may be large enough to activate additional receptors to enhance the recruitment process 27 .…”

Section: White Blood Cellsmentioning

confidence: 99%

See 2 more Smart Citations

Computational fluid dynamics in the microcirculation and microfluidics: what role can the lattice Boltzmann method play?

O’Connor

Day

Mandal

et al. 2016

Integrative Biology

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Patient-specific simulations, efficient parametric analyses, and the study of complex processes that are otherwise experimentally intractable are facilitated through the use of Computational Fluid Dynamics (CFD) to study biological flows. This review discusses various CFD methodologies that have been applied across different biological scales, from cell to organ level. Through this discussion the lattice Boltzmann method (LBM) is highlighted as an emerging technique capable of efficiently simulating fluid problems across the midrange of scales; providing a practical analytical tool compared to methods more attuned to the extremities of scale. Furthermore, the merits of the LBM are highlighted through examples of previous applications and suggestions for future research are made. The review focusses on applications in the midrange bracket, such as cellcell interactions, the microcirculation, and microfluidic devices; wherein the inherent mesoscale nature of the LBM renders it well suited to the incorporation of fluid-structure interaction effects, molecular/particle interactions and interfacial dynamics. The review demonstrates that the LBM has the potential to become a valuable tool across a range of emerging areas in bio-CFD, such as understanding and predicting disease, designing Lab-on-a-Chip devices, and elucidating complex biological processes.

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Section: Relevant Physics and Modelling Requirementsmentioning

confidence: 99%

Section: White Blood Cellsmentioning

confidence: 99%

Section: White Blood Cellsmentioning

confidence: 99%

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Computational fluid dynamics in the microcirculation and microfluidics: what role can the lattice Boltzmann method play?

O’Connor

Day

Mandal

et al. 2016

Integrative Biology

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“…8 Leukocyte adhesion is a multi-step process consisting of margination, tethering, rolling, and firm adhesion as shown in Fig. 3.…”

Section: Leukocytesmentioning

confidence: 99%

Hemodynamics in the Microcirculation and in Microfluidics

et al. 2014

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Hemodynamics in microcirculation is important for hemorheology and several types of circulatory disease. Although hemodynamics research has a long history, the field continues to expand due to recent advancements in numerical and experimental techniques at the micro-and nano-scales. In this paper, we review recent computational and experimental studies of blood flow in microcirculation and microfluidics. We first focus on the computational studies of red blood cell (RBC) dynamics, from the single cellular level to mesoscopic multiple cellular flows, followed by a review of recent computational adhesion models for white blood cells, platelets, and malaria-infected RBCs, in which the cell adhesion to the vascular wall is essential for cellular function. Recent developments in optical microscopy have enabled the observation of flowing blood cells in microfluidics. Experimental particle image velocimetry and particle tracking velocimetry techniques are described in this article. Advancements in micro total analysis system technologies have facilitated flowing cell separation with microfluidic devices, which can be used for biomedical applications, such as a diagnostic tool for breast cancer or large intestinal tumors. In this paper, cell-separation techniques are reviewed for microfluidic devices, emphasizing recent advances and the potential of this fast-evolving research field in the near future.

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“…Introduction. The theoretical and numerical study of fluid-structure or fluid-particle interaction problems is of major importance when modelling several phenomena occuring in the human cardiovascular system, like the rolling of white blood cells (see [1]), or the motion and design of prostetic heart valves (see [9] ). There are also important industrial applications involving the settling and lift-off of particles in channel flows in the petroleum and coal industries (see [2,7] and references therein).…”

mentioning

confidence: 99%

On a constrained minimization problem arising in hemodynamics

Janela

Sequeira²

2008

Parabolic and Navier–Stokes Equations

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Abstract. Experimental evidence collected over the years shows that blood exhibits nonNewtonian characteristics such as shear-thinning, viscoelasticity, yield stress and thixotropic behaviour. Under certain conditions these characteristics become relevant and must be taken into consideration when modelling blood flow. In this work we deal with incompressible generalized Newtonian fluids, that account for the non-constant viscosity of blood, and present a new numerical method to handle fluid-rigid body interaction problems. The work is motivated by the investigation of interaction problems occurring in the human cardiovascular system, where the rigid bodies may be blood particles, clots, valves or any structure that we may assume to move rigidly. This method is based on a variational formulation of the fully coupled problem in the whole fluid/solid domain, in which constraints are introduced to enforce the rigid motion of the body and the equilibria of forces and stresses at the interface. The main feature of the method consists in introducing a penalty parameter that relaxes the constraints and allows for the solution of an associated unconstrained problem. The convergence of the solution of the relaxed problem is established and some numerical simulations are performed using common benchmarks for this type of problems. The paper is in final form and no version of it will be published elsewhere.[227] c Instytut Matematyczny PAN, 2008 228 J. JANELA AND A. SEQUEIRA 1. Introduction. The theoretical and numerical study of fluid-structure or fluid-particle interaction problems is of major importance when modelling several phenomena occuring in the human cardiovascular system, like the rolling of white blood cells (see [1]), or the motion and design of prostetic heart valves (see [9] ). There are also important industrial applications involving the settling and lift-off of particles in channel flows in the petroleum and coal industries (see [2,7] and references therein). The rheological characteristics of blood are determined by its complex morphology that we will briefly describe (for details see Sequeira and Janela [16], Robertson, Sequeira and Kameneva [15] and Robertson Sequeira and Owens [14]). Blood is a complex mixture consisting of different particles (erythrocytes, leukocytes, platelets and other matter) suspended in an aqueous polymer solution, the plasma (Newtonian fluid). These suspended particles, consisting mostly of erythrocytes (red blood cells) form about 45% of the volume of normal human blood and their effect should not be ignored. It is not feasible to track the individual behaviour of each RBC but it is possible to build homegenized models that reproduce the main non-Newtonian effects caused by their presence.

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Leukocytes rolling and recruitment by endothelial cells: Hemorheological experiments and numerical simulations

Cited by 21 publications

References 28 publications

Computational fluid dynamics in the microcirculation and microfluidics: what role can the lattice Boltzmann method play?

Computational fluid dynamics in the microcirculation and microfluidics: what role can the lattice Boltzmann method play?

Hemodynamics in the Microcirculation and in Microfluidics

On a constrained minimization problem arising in hemodynamics

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