Leukocytoclastic vasculitis associated with crusted scabies

Pruritic erythematous to violaceous macules and papules with petechiae and excoriations

“…It manifests as multiple palpable purpura, urticarial papules and plaques, and/or targetoid lesions. LCV associated with scabies, although rare, has been previously reported in the literature 2‐10 . Two of these cases were associated with glomerulonephritis, 3,7 one case involved a patient with HIV, 4 another a female patient with B‐cell lymphoma on steroids, chemotherapy, and radiation 6 , and one patient had concomitant impetigo 2 .…”

“…Complete regression of skin lesions was achieved with scabies treatment only, without any specific treatment for the vasculitis. Treatments included benzyl benzoate, crotamiton, and systemic corticosteroids, 2 lindane 1% in three cases, 3,4 permethrin lotion 5% and systemic corticosteroids, 5 benzyl benzoate and ivermectin, 6 benzyl benzoate alone, 7 sulfur‐based ointment along with systemic corticosteroids, 8 oral ivermectin and synthetic pyrethroid lotion in two cases, 9 and oral ivermectin with topical phenothrin 10 …”

“…Scabietic vasculitis is, therefore, thought to be a hypersensitivity reaction to these antigens; however, these have yet to be identified. Nishihara et al 10 . hypothesized that the scabietic mites themselves or their metabolic products are the possible triggers.…”

Crusted scabies triggering autonomic dysreflexia in a patient with spinal cord injury

“…Nine cases of scabies causing leukocytoclastic vasculitis have been reported. 6 Scabies infestation has also been associated with exacerbations of chronic obstructive pulmonary disease and bullous pemphigoid. 7 In all these disorders, it is hypothesized that the presence of the scabies mite causes a hypersensitivity-like reaction and immunoresponse to an unknown antigen in individuals affected.…”

“…7 In all these disorders, it is hypothesized that the presence of the scabies mite causes a hypersensitivity-like reaction and immunoresponse to an unknown antigen in individuals affected. 6 Recently, there also have been increased data to support that patients with a history of treated scabies are at a long-term higher risk for other systemic diseases, such as autoimmune disease or stroke. A recent population-based cohort study revealed that compared with matched controls, patients with a history of scabies showed an increased risk of developing hypersensitivity vasculitis, dermatomyositis, polyarteritis nodosa, systemic lupus erythematosus, psoriasis, myasthenia gravis, type 1 diabetes mellitus, pernicious anemia, and rheumatoid arthritis in a 7-year period.…”