Leukocytoclastic Vasculitis Related to Cocaine Use

Salas-Espíndola, Y.; Peniche-Castellanos, Amelia; López-Gehrke, I.; Mercadillo-Pérez, Patricia

doi:10.1016/j.adengl.2012.01.003

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…An increase in cocaine abuse worldwide is leading to a rise in associated pathology . Inhalation of cocaine can result in nasal inflammation and necrosis because of its vasoconstrictor effect, microtraumas caused by the cocaine itself and accompanying substances, and an increased incidence of infections caused by Staphylococcus aureus .…”

Section: Reportmentioning

confidence: 99%

Pyoderma gangrenosum and Wegener granulomatosis-like syndrome induced by cocaine

Jiménez‐Gallo

Albarrán-Planelles

Linares‐Barrios

et al. 2013

Clinical and Experimental Dermatology

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Cocaine abuse is associated with various skin and rheumatological diseases that mimic primary autoimmune diseases, including retiform purpura with involvement of the ears, cocaine-induced midline destructive lesions (CIMDL), and eruptive pyoderma gangrenosum (PG). Previous reports have suggested the use of perinuclear antineutrophil cytoplasmic antibodies (pANCA) with specificity against human neutrophil elastase (HNE) to differentiate these cocaine-induced diseases from primary autoimmune diseases. We describe a case of a 54-year-old woman with a history of cocaine abuse, who had PG lesions on her legs with accompanying CIMDL and lung lesions similar to those seen in Wegener granulomatosis. Detection of HNE-positive pANCA, and improvement or clinical recurrence after cessation or consumption of cocaine, respectively, were key to differentiating this presentation from primary autoimmune disease.

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Section: Reportmentioning

confidence: 99%

Pyoderma gangrenosum and Wegener granulomatosis-like syndrome induced by cocaine

Jiménez‐Gallo

Albarrán-Planelles

Linares‐Barrios

et al. 2013

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…Bunlardan biri Salas-Espíndola'nın bildirdiği olgudur (10). Bu olguda kol, bacak ve kalçalarda değişik şekillerde pürülan eksüda ile kaplı yer yer nekrotik kurutlanmaların olduğu ülserasyonlar görülmüştür.…”

Section: Olguunclassified

“…Vaskülitlerde ANCA'nın patogenezdeki rolü halen tartışma konusudur. Ancak öne sürülen bir hipoteze göre ANA, ANCA gibi otoantikorların nötrofillleri uyardığı ve degranülasyona neden olduğu, toksik oksijen metabolitlerinin salınımıyla beraber endotel hasarına yol açtığı düşünülmektedir (10,11). İn vitro çalışmalarda kokainin tromboksan sentezini ve platelet aktivitesini artırdığı gösterilmiştir.…”

Section: Olguunclassified