Leukocytosis due to adrenal metastases from malignant melanoma: Reversal after bilateral adrenalectomy with long‐term survival

Carey, Robert W.; Kunz, Victoria S.

doi:10.1002/ajh.2830270317

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…Two of these studies that have been conducted at the Memorial Sloan-Kettering Cancer Center of New York (81) and Mayo Clinic (73), respectively, summarized the data. The remaining nine studies (1,21,22,61,62,82,(85)(86)(87)(88)(89) contained sufficient data but number of cases was small or had insufficient data. The larger of these two studies, conducted by Branum and associates, have compared surgical with non-surgical treatment of 24 patients with melanoma metastatic to the adrenals.…”

Section: Surgical Treatment -Other Primary Sitesmentioning

confidence: 99%

Metastatic Carcinomas of the Adrenal Glands: From Diagnosis to Treatment

et al. 2019

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Section: Surgical Treatment -Other Primary Sitesmentioning

confidence: 99%

Metastatic Carcinomas of the Adrenal Glands: From Diagnosis to Treatment

et al. 2019

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“…Of the documented 40 adrenalectomies for NSCLC and 35 contralateral adrenal resections for renal carcinoma, the long-term survival has been estimated to be greater than 40% and 60%, respectively. Other reports also have described the resection of adrenal metastases from melanoma with extended disease-free survival [16,17].…”

Section: Introductionmentioning

confidence: 98%

Laparoscopic adrenalectomy for cancer

Heniford

Arca

Walsh

et al. 1999

Semin. Surg. Oncol.

192

106

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We will review the literature on the operative techniques and patient outcomes of laparoscopic adrenalectomy for cancer. Further, in our own study, an analysis of the preoperative assessment, operative, and hospital course, and postoperative follow‐up was performed on all patients undergoing a laparoscopic adrenalectomy for cancer or metastasis from October 1996 through February 1998. Twelve laparoscopic resections were performed in 11 patients. There were six males and five females with an average age of 62 years (range, 40 to 79). The mean American Society of Anesthesiologists (ASA) score was 3.1 (range, 2 to 4). All of the tumors except one were due to metastatic cancer. The metastatic sources included renal cell cancer (four), lung cancer (two), colon cancer (two), adrenal cancer (one), and melanoma (one). Seven patients required a left adrenalectomy, three underwent a right adrenalectomy, and one was bilateral. The approach was transperitoneal in eight cases and retroperitoneal in four. The mean size of the tumors was 5.9 cm (range, 1.8 to 12 cm). Operative time averaged 181 minutes (range, 100 to 315 minutes), and blood loss was 138 cc (range, 20 to 1,300 cc). Average hospital stay was 2.3 days(range, <1 to 6 days). One patient required conversion to an open approach due to local invasion of the tumor into the lateral wall of the vena cava, which was resected with the specimen. This procedure resulted in the largest blood loss of the series (1,300 cc). All specimens had negative surgical margins. There was one complication (9%), a laceration of the epigastric artery, which was controlled laparoscopically. At a mean follow‐up of 8.3 months (range, 0.5 to 19 months), there have been no port site or local recurrences. One patient has developed a new hepatic nodule, which is being worked up for metastatic disease. Ten of the 11 patients (91%) are currently alive; one has died of expansive cerebral metastases from melanoma. Semin. Surg. Oncol. 16:293–306, 1999. © 1999 Wiley‐Liss, Inc.

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“…Some previous reports have noted that the monitoring of WCCs could be an indicator of tumour response to chemotherapy or radiotherapy or, on the contrary, a marker of recurrence 8 9. A previous report by Carey and Kunz11 in 1988 related the reversal of leucocytosis after bilateral adrenalectomy in a patient with malignant melanoma with adrenal metastases, and this was related with improved survival. Interestingly, our patient also presented with bilateral adrenal metastasis.…”

Section: Discussionmentioning

confidence: 85%

Paraneoplastic leukemoid reaction in a patient with BRAF V600E-mutated metastatic malignant melanoma

Gouveia¹,

Sousa²,

Passos³

et al. 2015

BMJ Case Reports

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A paraneoplastic leukemoid reaction is a rare condition of extreme leucocytosis in patients with solid malignancies. The differential diagnosis is often a true challenge. We present a case of a 56-year old woman with a history of stage IIIA malignant melanoma resected in 2004 that was diagnosed in May 2013 with BRAF V600E-mutated metastatic disease (left arm mass, lungs and adrenal glands). The laboratory findings revealed leucocytosis with granulocytosis that increased progressively to values up to 120.0 × 10(9)/L. After a diagnostic work-up, a diagnosis of a paraneoplastic leukemoid reaction was established. We report the response of leucocytosis to radiation and BRAF inhibitor therapy, albeit short-lived. To the best of our knowledge, this is the first case report of a paraneoplastic leukemoid reaction in metastatic melanoma with characterisation of BRAF V600 mutation status. It remains unclear whether the aggressive tumour phenotype is related to the leukemoid reaction and whether this is related to the BRAF mutation.

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Leukocytosis due to adrenal metastases from malignant melanoma: Reversal after bilateral adrenalectomy with long‐term survival

Cited by 9 publications

References 7 publications

Metastatic Carcinomas of the Adrenal Glands: From Diagnosis to Treatment

Metastatic Carcinomas of the Adrenal Glands: From Diagnosis to Treatment

Laparoscopic adrenalectomy for cancer

Paraneoplastic leukemoid reaction in a patient with BRAF V600E-mutated metastatic malignant melanoma

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