2015
DOI: 10.1128/jcm.02853-14
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Leukodepletion as a Point-of-Care Method for Monitoring HIV-1 Viral Load in Whole Blood

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Cited by 15 publications
(18 citation statements)
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“…The SAMBA II system is a simple "sample in-result out" platform designed for resource-limited and POC settings and has been used for HIV testing at the POC [9][10][11][12][13]. The instruments can operate in high heat and humidity (10-38°C; 5-95%) and reagents are stable at room temperature (up to 37 o C) for up to 6 months.…”
Section: Discussionmentioning
confidence: 99%
“…The SAMBA II system is a simple "sample in-result out" platform designed for resource-limited and POC settings and has been used for HIV testing at the POC [9][10][11][12][13]. The instruments can operate in high heat and humidity (10-38°C; 5-95%) and reagents are stable at room temperature (up to 37 o C) for up to 6 months.…”
Section: Discussionmentioning
confidence: 99%
“…The test result is visually scored on a lateral flow assay (LFA) format with a viral load threshold of 1,000 copies/ml. The SAMBAs currently use plasma, adding 15 to 20 min to the test processing time and requiring a refrigerated centrifuge, although a whole-blood testing format is in development (54,55). The SAMBA I semi-Q prototype assay had a reported 96.6% (CI not reported) concordance with the Roche COBAS AmpliPrep/COBAS TaqMan (57).…”
Section: Currently Available Testsmentioning
confidence: 99%
“…Other features of the instrument include the possession of Bluetooth connectivity, and thus, the results can be electronically transmitted. To limit the interference of cellular nucleic acids, the manufacturer has developed a miniaturize leukodepletion column that can deplete more than 99.9% of white blood cells (WBCs) from 100 l venous whole blood (230). The new device with the built-in WBC-depleting component significantly improved the assay for VL testing.…”
Section: Poc Vl Testing Platformsmentioning
confidence: 99%