Leukodin isolated from Artemisia capillaris inhibits alpha-melanocyte stimulating hormone induced melanogenesis in B16F10 melanoma cells

Woo, Sung Min; Choi, Woo Rin; Lee, Dong‐Ryung; Kim, Hong-Suk; Yi, Chunsik; Kim, Kyung-Hyeon; Kim, Hae‐Lim; Cheng, Jinhua; Le, Bao Han A.; Suh, Joo‐Won

doi:10.1016/j.eujim.2018.10.013

Cited by 5 publications

(7 citation statements)

References 23 publications

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“…Regulation of melanogenesis in melanocytes and melanoma cells is mediated through a series of enzymatic reactions coordinated by the enzyme tyrosinase. Tyrosinase can form dopaquinone from tyrosine, which is considered as the rate‐limiting step of melanogenesis . As tyrosinase has been recognized as the rate‐limiting enzyme involved in melanin synthesis, effects of ALE on tyrosinase activity were assessed in α‐MSH‐stimulated B16F10 cells.…”

Section: Resultsmentioning

confidence: 99%

“…Tyrosinase can form dopaquinone from tyrosine, which is considered as the rate-limiting step of melanogenesis. [16][17][18] As tyrosinase has been recognized as the rate-limiting enzyme involved in melanin synthesis, effects of ALE on tyrosinase Figure 3A). Results revealed that the intracellular tyrosinase activities were 85.06 ± 14.25%, 79.60 ± 14.15%, and 70.34 ± 4.07% compared with α-MSH control at 1.25, 2.5, and 5 ng/mL of ALE treatments, respectively.…”

Section: Effects Of Ale On Tyrosinase Activitymentioning

confidence: 99%

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Annona squamosa L. leaves inhibit alpha‐melanocyte‐stimulating hormone (α‐MSH) stimulated melanogenesis via p38 signaling pathway in B16F10 melanoma cells

Kang

Moon

et al. 2019

J of Cosmetic Dermatology

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Background Annona squamosa L. is a branched shrub, which is believed to be originated from the America and West Indies. Fruits of this plant are commonly known as custard apple, sugar apple, or sweetsops. A number of studies have proven a range of biological activities associated with various parts of A. squamosa. Aims The main aim of the present investigation was to evaluate potential inhibitory effects of A. squamosa leaf extract (ALE) on melanogenesis and its underlying mechanisms in B16F10 murine melanoma cells. Methods Inhibitory effects of A. squamosa leaf extract (ALE) on melanogenesis were primarily assessed by determining melanin contents. Effects of ALE on tyrosinase activity and the expression of proteins associated with melanogenesis were then determined. GC–MS analysis was carried out to identify the phytochemical profile of A. squamosa leaf extract. Results Antimelanogenic effects of ALE were found to exert through the inhibition of melanocyte inducing transcription factor (MITF) and activation of p38. GC‐MS analysis identified ent‐kaur‐16‐en‐19‐ol, 18‐oxokauran‐17‐yl acetate, and β‐sitosterol as major phytochemicals. Conclusion To our knowledge, this is the first study on the antimelanogenic effects of A. squamosa leaves, rationalizing the use A. squamosa leaf extract as a natural depigmentation agent for the treatment of skin diseases and the development of cosmetic products with enhanced skin‐lightening capabilities.

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Section: Resultsmentioning

confidence: 99%

Section: Effects Of Ale On Tyrosinase Activitymentioning

confidence: 99%

Annona squamosa L. leaves inhibit alpha‐melanocyte‐stimulating hormone (α‐MSH) stimulated melanogenesis via p38 signaling pathway in B16F10 melanoma cells

Kang

Moon

et al. 2019

J of Cosmetic Dermatology

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“…Woo et al explored the in vitro antimelanogenesis and antityrosinase effects of Artemisia capillaris (100% ethanol extract) in different concentrations on B16F10 melanoma cells . The results obtained showed that the extract reduced the cellular melanin content in a dose-dependent manner in α-MSH-stimulated B16F10 cells, with a 40.24% inhibition at 50 μg/mL.…”

Section: Biological Activitiesmentioning

confidence: 99%

Searching for Natural Plants with Antimelanogenesis and Antityrosinase Properties for Cosmeceutical or Nutricosmetics Applications: A Systematic Review

Tung,

Yip,

Gew

2023

ACS Omega

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Excessive UV radiation (UVR) exposure has been shown in studies to be a major risk factor for most melanomas, causing premature skin aging as well as immune system suppression due to the increased production of hydrogen peroxide (H2O2) and other reactive oxygen species (ROS) during the melanogenesis process. Although several compounds with antioxidant and antityrosinase activities are widely used in the cosmetic industry, like kojic acid, hydroquinone, ascorbic acid, and arbutin, their use has been limited due to their adverse effects on the skin and cytotoxic issues. Recently, attempts have been made to develop new natural skin-lightening products by using plant extracts that are less toxic and exhibit numerous biological properties with great market demand. In this study, information on the depigmentation effects of various natural plant species was gathered from the SCOPUS database according to the PRISMA guidelines. A total of 414 records were retrieved, and finally, 76 articles were included in the qualitative synthesis by fulfilling all the inclusion criteria. In this review, we discuss the extraction methods and biological assays of 75 highly potential plant species, including the olive, yuzu, longan, and lotus. We concluded that the use of natural plants as skin-whitening agents is highly effective as there is a significant correlation between the content of polyphenolic compounds, antimelanogenesis, antityrosinase, and antioxidant activities. However, it is worth noting that the use of extraction methods or types of solvents is very important in determining the biological activities of plants.

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“…Western blot showed that Artemisia Extract downregulated the expression of melanocyte-specific proteins such as tyrosinase, protein tyrosinase-1 (TRP- 1), and protein tyrosinase-2, which catalyzes the rate oxidation of tyrosine to melanin, inhibits melanin pigment synthesis and tyrosinase activity in B16F10 melanoma cells. (Woo et al, 2019). The activity of eupatilin against other melanoma skin cancer has not been explored yet.…”

Section: Artemisia Lmentioning

confidence: 99%

Phytochemical Profile and Anticancer Activity from Medicinal Plants Against Melanoma Skin Cancer: A Review

Fristiohady¹,

Asasutjarit²,

Purnama³

et al. 2022

Indonesian J. Sci. Technol

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Melanoma skin cancer is a malignant melanocyte tumor considered the most invasive and dangerous skin cancer, with an average five-year survival rate of less than 5% after metastasis. Thus, a new strategy for preventing and treating cancer from the natural product is required. Medicinal plants are the potential as an alternative against cancer. This review article aims to determine natural products from medicinal plants which have the potential as an anticancer in melanoma skin cancer in vitro and in vivo. 40 plants have been selected based on the selection criteria for anticancer compounds. In vitro studies showed that the plant can reduce cell viability through cell cycle inhibition and apoptosis induction and inhibit angiogenesis, invasion, and metastasis in human melanoma skin cancer. Therefore, further research is required to explore more plants, especially medicinal plants, their active compounds, and the mechanism of anticancer action to be used as standard herbal medicines.

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Leukodin isolated from Artemisia capillaris inhibits alpha-melanocyte stimulating hormone induced melanogenesis in B16F10 melanoma cells

Cited by 5 publications

References 23 publications

Annona squamosa L. leaves inhibit alpha‐melanocyte‐stimulating hormone (α‐MSH) stimulated melanogenesis via p38 signaling pathway in B16F10 melanoma cells

Annona squamosa L. leaves inhibit alpha‐melanocyte‐stimulating hormone (α‐MSH) stimulated melanogenesis via p38 signaling pathway in B16F10 melanoma cells

Searching for Natural Plants with Antimelanogenesis and Antityrosinase Properties for Cosmeceutical or Nutricosmetics Applications: A Systematic Review

Phytochemical Profile and Anticancer Activity from Medicinal Plants Against Melanoma Skin Cancer: A Review

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