Leukoencephalopathy And Dermatomyositis In Hodgkin's Disease

Lymphocyte stimulation with muscle homogenate in polymyositis and other muscle-wasting disorders.

“…On the other hand, polymyositis has occurred in association with Hodgkin's disease (Deep, Fraumeni, Tashima, and McDivitt, 1964), in whichthere is an early depression of delayed hypersensitivity (Aisenberg, 1966) and impaired lymphocyte transformation with phytohaemagglutinin (Hersh and Oppenheim, 1965).…”

Progressive multifocal leucoencephalopathy

“…With the present report, approximately 30 cases of progressive multifocal leucoencephalopathy have been published; six more have been mentioned in the reports of Richardson (1961), Weinstein, Woolf, and Meynell (1963), and Deep, Fraumeni, Tashima, and McDivitt(1964), and Rubinstein(1964) has reviewed at least two cases. Although the disease may now be suspected during life, the diagnosis can only be made with certainty on biopsy or necropsy material; and the former method, as well as electron microscope studies, yet awaits trial.…”

“…In 1961, Richardson, supported by Waksman and Adams (1962a, b), put forward the hypothesis that progressive multifocal leucoencephalopathy is a viral disease which affects individuals with deficient immune response due to their primary disease, most commonly a disorder of the reticuloendothelial system, i.e., lymphatic leukaemia or Hodgkin's disease. Since then the viral theory has received the most support and discussion, although (Headington and Umiker, 1962;Deep et al, 1964), and excess activity of the reticulo-endothelial system (Weinstein et al, 1963). Cavanagh, Greenbaum, Marshall, and Rubinstein (1959) also suggested a disturbance involving lipid metabolism, in particular that of sphingomyelin.…”

Cerebellar degeneration with Hodgkin's disease.

“…Cranial and peripheral nerve lesions as well as paraplegia were discussed and one case of polymyositis in Hodgkin's disease was described. Deep, Fraumeni, Tashima, and McDivitt (1964) report leucoencephalopathy and dermato-myositis in a case of Hodgkin's disease. In none of these papers were there any case reports of subacute cerebellar cortical degeneration associated with reticulosis.…”