Leukopenia of Asymptomatic COVID-19 Infections under 18 Years Old in Recovery Stage

Zhang, Wei; Yuan, Youshu; Yang, Zhengqiao; Fu, Jinxia; Zhang, Yun; Ma, Ming; Wu, Weidong; Zhou, Hourong

doi:10.1101/2020.05.21.20074682

Cited by 1 publication

(1 citation statement)

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“…At presentation, the median level of white blood cell (WBC) counts was significantly lower among patients in ICU ( p = 0.0448) ( Table 3 ). This may be due to viral erosion that results in direct inflammation and infection and consequently, excessive destruction of WBCs [ 36 ]. This is in agreement with previous studies reporting an association between decreased levels of WBCs in COVID-19 patients at presentation and disease severity and adverse outcomes [ 9 , 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

Clinical Characteristics and Serum Cytokines Profiling in Hospitalized COVID-19 Patients in Lebanon

Hassan

Hamdan

Melhem

2023

Journal of Immunology Research

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Since its emergence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a public health threat worldwide. While the majority of patients recover in 3–4 weeks, complications in severely ill patients, including acute respiratory distress syndrome, cardiac injury, thrombosis, and sepsis, can lead to death. Several biomarkers, in addition to cytokine release syndrome (CRS), have been associated with severe and fatal outcomes in coronavirus disease 2019 (COVID-19) patients. The aim of this study is to assess clinical characteristics and cytokines profiles in hospitalized COVID-19 patients in Lebanon. A total of 51 hospitalized COVID-19 patients were recruited between February 2021 and May 2022. Clinical data and sera were collected at two time points: at hospital presentation (T0) and last collected results during hospitalization (T1). Our results showed that 49% of participants were >60 years with males accounting for the majority (72.5%). Hypertension, followed by diabetes and dyslipidemia, were the most frequent comorbid conditions among study participants accounting for 56.9% and 31.4%, respectively. Chronic obstructive pulmonary disease (COPD) was the only significantly different comorbid condition between intensive care unit (ICU) and non-ICU patients. Our results also showed that the median level of D-dimer was significantly elevated among patients in ICU and those who died compared to non-ICU patients and those who survived. Moreover, C-reactive protein (CRP) levels were significantly higher at T0 compared to T1 in ICU and non-ICU patients. The median level of IL-12p70 was significantly higher in patients >60 years compared to those ≤60 years ( p = 0.0209 ). Our data are in agreement with previous reports suggesting the importance of IL-6, CRP, and IL-12p70 in the assessment of risk of severe disease and mortality.

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