Leukopenie Nach Intravenöser Zufuhr Kolloidaler Kohlehydrate

Staub, H.; Mezey, K.; Golandas, G.

doi:10.1007/bf01768989

Cited by 13 publications

(3 citation statements)

References 7 publications

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“…Fletcher, Martin, and Ratcliffe (1952) have shown that polyvinylpyrrolidone, acacia and laminarin also interact with fibrinogen in a similar manner. Staub, Mezy, and Golondas (1938) described the occurrence of leucopenia and agglutination of leucocytes in rabbits given glycogen and gum acacia. This was confirmed and extended by Bucher (1939), who observed that platelets were also affected.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Toxicity of a Series of Dextran Sulphates of Varying Molecular Weight

Walton

1954

British Journal of Pharmacology and Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Investigation of the Toxicity of a Series of Dextran Sulphates of Varying Molecular Weight

Walton

1954

British Journal of Pharmacology and Chemotherapy

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“…A search of the literature revealed that the capacity of bacteria and bacterial products to produce leucopenia and thrombocytopenia has been described (7)(8)(9), and similar changes have also been noted following the intravenous injection of glycogen (10,11). The occurrence of similar changes in these blood elements has also been observed after the injection of the specific antigen in a sensitized animal, and this phenomenon has been regarded by some (12,13) as an important feature of anaphylaxis.…”

Section: Hematologic Changes Following the Intravenous Injection Of Mmentioning

confidence: 99%

Studies on the Mechanism of the Shwartzman Phenomenon

Stetson

1951

Journal of Experimental Medicine

171

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In an earlier study (1) an attempt was made to determine whether there might be a demonstrable biochemical abnormality in skin prepared for the Shwartzman phenomenon. Investigation of the carbohydrate metabolism of such prepared skin sites revealed the presence of a striking and consistent deviation from normal, in the form of a pronounced degree of aerobic glycolysis. As a result of this atypical form of glucose utilization, such skin sites contain large amounts of lactic acid. It was suggested that the ultimate blood vessel disruption might be due to the action of proteolytic enzymes or "cathepsins," and it was pointed out that the occurrence of aerobic glycolysis provided local conditions favoring the action of such enzymes. Evidence was subsequeutly presented (2) to indicate that the observed aerobic glycolysis in prepared skin sites was largely due to the influx of exudate polymorphonuclear leucocytes, rather than to a direct alteration of the metabolism of intrinsic skin elements by the intradermally injected toxin.In the present study, attention was turned to the changes which occur following the intravenous challenging injection, in an effort to ascertain the nature of the mechanisms involved in the final blood vessel damage and the production of hemorrhagic necrosis. Evidence will be presented to indicate that the capillaries and veins in skin areas prepared for the Shwartzman phenomenon exhibit a marked vulnerability to a peculiar sort of cellular thrombosis induced by the challenging injection. The resulting damage to the involved blood vessels and the surrounding tissue elements constitutes a type of tassue damage which, it is believed, has not been previously described. Materials and MethodsAniraals.--Hybrid male and female rabbits, weighing 1500 to 2000 gin., from the Rockefeller Institute stock were used throughout the experiments. Litter-mate controls were used

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“…The depression caused by the cytopenic substances on passive transfer was also much shorter and less intensive than that with known leukocyte and platelet antibodies (3,4,5,6,19,30,31). It can be compared with the action of high molecular substances (37,38) or bacterial pro teins (39), and seems to be rather a non-specific reaction than an acquired immunological phenomenon (36,40).…”

Section: Fig 9 Changes In the Leukocyte (--------) And Platelet (--mentioning

confidence: 99%

Humoral Factors in the Pathogenesis of Chronic Pancytopenias and Their Relation to Hypersplenism

Koszewski¹

1960

Acta Haematol

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Leukopenie Nach Intravenöser Zufuhr Kolloidaler Kohlehydrate

Cited by 13 publications

References 7 publications

Investigation of the Toxicity of a Series of Dextran Sulphates of Varying Molecular Weight

Investigation of the Toxicity of a Series of Dextran Sulphates of Varying Molecular Weight

Studies on the Mechanism of the Shwartzman Phenomenon

Humoral Factors in the Pathogenesis of Chronic Pancytopenias and Their Relation to Hypersplenism

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