Leukopheresis therapy for severe infantile pertussis with myocardial and pulmonary failure

Grzeszczak, Marek; Churchwell, Kevin B.; Edwards, Kathryn M.; Pietsch, John B.

doi:10.1097/01.pcc.0000235253.19315.56

Cited by 39 publications

(27 citation statements)

References 20 publications

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“…This may reflect a hyperviscosity syndrome from the elevated WBC count. Several case reports suggested improved outcomes using exchange transfusion to reduce the WBC count (151,306,(364)(365)(366)(367)(368)(369)(370).…”

Section: Nonmacrolide Treatmentsmentioning

confidence: 99%

Pertussis: Microbiology, Disease, Treatment, and Prevention

et al. 2016

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SUMMARYPertussis is a severe respiratory infection caused byBordetella pertussis, and in 2008, pertussis was associated with an estimated 16 million cases and 195,000 deaths globally. Sizeable outbreaks of pertussis have been reported over the past 5 years, and disease reemergence has been the focus of international attention to develop a deeper understanding of pathogen virulence and genetic evolution ofB. pertussisstrains. During the past 20 years, the scientific community has recognized pertussis among adults as well as infants and children. Increased recognition that older children and adolescents are at risk for disease and may transmitB. pertussisto younger siblings has underscored the need to better understand the role of innate, humoral, and cell-mediated immunity, including the role of waning immunity. Although recognition of adult pertussis has increased in tandem with a better understanding ofB. pertussispathogenesis, pertussis in neonates and adults can manifest with atypical clinical presentations. Such disease patterns make pertussis recognition difficult and lead to delays in treatment. Ongoing research using newer tools for molecular analysis holds promise for improved understanding of pertussis epidemiology, bacterial pathogenesis, bioinformatics, and immunology. Together, these advances provide a foundation for the development of new-generation diagnostics, therapeutics, and vaccines.

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Section: Nonmacrolide Treatmentsmentioning

confidence: 99%

Pertussis: Microbiology, Disease, Treatment, and Prevention

et al. 2016

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“…La déplétion spécifique des leucocytes par leucocytaphérèse automatisée est la solution de choix mais elle nécessite un matériel spécifique peu disponible et une anticoagulation du circuit qui est susceptible d'induire des troubles de l'hémostase chez l'enfant de faible poids [8]. Cependant, la leucocytaphérèse est une option intéressante chez l'enfant déjà sous assistance extra-corporelle [9,10]. Le principe de l'EST repose sur l'échange manuel d'une (simple volume) à 2 (double volume) masses sanguines avec du sang total reconstitué à partir de concentrés de globules rouges appauvris en leucocytes et de plasma frais congelé ou d'albumine pour une hématocrite cible généralement à 45 %.…”

Section: Discussionunclassified

Coqueluche maligne et exsanguino-transfusion

Chantreuil

Fakhri

Labarthe

et al. 2015

Archives de Pédiatrie

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“…Normalice el calcio, el fósforo, el magnesio, el sodio, el potasio, la glucemia. 19,26 se realizó exanguinotransfusión, ambos con desenlace fatal, mientras que, en el trabajo de Grzeszczak y cols., 25 se describe por primera vez en la literatura un procedimiento de leucoféresis en una paciente de 5 semanas de vida con diagnóstico de coqueluche y expuesta a ECMO. Dicho tratamiento fue efectivo y logró un descenso de GB del 80% (de 72 000 a 14 400 mm 3 ) y, consecuentemente, la supervivencia.…”

Section: Tratamientos De Leucorreducciónunclassified