Leukoreduced red blood cell transfusions do not induce platelet glycoprotein antibodies in patients with sickle cell disease

Abstract

Leukocyte-reduced RBC transfusions do not appear to induce platelet-specific glycoprotein antibodies. The positive platelet-specific glycoprotein antibody results from this study may represent platelet autoantibodies, platelet alloantibodies, or false-positive reactions. A better understanding of the immunobiology of patients with SCD at baseline and after blood product exposure may help improve future transfusion and transplantation.

Human leukocyte antigen (HLA) class I antibodies and transfusion support in paediatric HLA‐matched haematopoietic cell transplant for sickle cell disease

“…Additional variables, including patient age, transplant donor/recipient ABO matching, conditioning regimen, and the incidence of acute GVHD, were also evaluated. As previous work has suggested that RBC transfusions do not appear to cause human platelet antigen (HPA) antibodies (Nickel et al , ), HPA alloimmunization was not studied.…”