2004
DOI: 10.1016/j.transproceed.2004.07.039
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Leukoreduction and acute rejection in liver transplantation: An interim analysis

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Cited by 7 publications
(6 citation statements)
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“…Trauma patients constituted a small minority of the study population, and no subset analysis of trauma patients was performed. Others have described LR blood product utilization as being associated with lower rates of rejection in liver transplantation [26], decreased sepsis from indwelling venous access [27], and decreased LOS in open heart surgery [29].…”
Section: Discussionmentioning
confidence: 99%
“…Trauma patients constituted a small minority of the study population, and no subset analysis of trauma patients was performed. Others have described LR blood product utilization as being associated with lower rates of rejection in liver transplantation [26], decreased sepsis from indwelling venous access [27], and decreased LOS in open heart surgery [29].…”
Section: Discussionmentioning
confidence: 99%
“…Prestorage leukoreduction effectively removes 99.9% of donor WBCs with the goal of abrogating any immunomodulatory effects resulting from donor leukocytes and their associated bioreactive mediators. Both bench and clinical studies of the benefits and consequences of prestorage leukoreduction have yielded mixed results. Fergusson et al used meta‐analysis of clinical trials to determine that RBC leukoreduction reduces postoperative infection in people, but found no reduction of cancer recurrence or perioperative mortality in recipients.…”
Section: Immunologic Changesmentioning
confidence: 99%
“…In a retrospective cohort study comparing outcomes in transfusion recipients undergoing major surgeries before ( n = 6,982) and after ( n = 7,804) institution of universal leukoreduction, the same investigators found that leukoreduction was associated with a decreased incidence of fever episodes, antimicrobial use, and mortality in those high‐risk patients . The use of leukoreduced blood has also been associated with fewer early rejection episodes in patients with liver transplantation, irrespective of the type of immunosuppression suggesting a possible immunomodulatory effect of leukoreduced blood . However, not all studies have shown a benefit of using leukoreduced blood.…”
Section: Immunologic Changesmentioning
confidence: 99%
“…[ 34 ] To counter this, leukoreduction technologies are being used currently. [ 35 36 ] In addition, the transfusion of allogenic blood products leads to a decrease in immunity and more postoperative infections and multiple organ failure. [ 31 32 ]…”
Section: Why We Need To Minimize Transfusion During Liver Transplantamentioning
confidence: 99%