1985
DOI: 10.1203/00006450-198505000-00006
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Leukotriene Inhibition Prevents and Reverses Hypoxic Pulmonary Vasoconstriction in Newborn Lambs

Abstract: ABSTRACT. The effects of the leukotriene antagonist FPL 57231 on the circulation were studied in spontaneously breathing normoxic and hypoxic newborn lambs in order to evaluate the role of leukotrienes in the perinatal control of hypoxic pulmonary vasoconstriction. Hypoxia produced a 58% increase in pulmonary arterial pressure The exact mechanisms by which hypoxia produces pulmonary vasoconstriction remain unknown. The production and release of the noncyclooxygenase products of arachidonic acid from the lung m… Show more

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Cited by 42 publications
(23 citation statements)
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“…Therefore, FPL57231 is not a thromboxane receptor antagonist. In some studies, FPL5723 1 has decreased vascular pressures and tended to increase cardiac output (43,44), but not in others (5,17). In pump-perfused fetal goat lungs, very large bolus doses of FPL57231 (to 10 mg/kg) prevented the pulmonary pressor response to leukotriene D4 and lowered normal pulmonary vascular resistance (45).…”
Section: Discussionmentioning
confidence: 99%
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“…Therefore, FPL57231 is not a thromboxane receptor antagonist. In some studies, FPL5723 1 has decreased vascular pressures and tended to increase cardiac output (43,44), but not in others (5,17). In pump-perfused fetal goat lungs, very large bolus doses of FPL57231 (to 10 mg/kg) prevented the pulmonary pressor response to leukotriene D4 and lowered normal pulmonary vascular resistance (45).…”
Section: Discussionmentioning
confidence: 99%
“…Metabolites of arachidonic acid may mediate the pulmonary vasoconstriction seen in utero (1,2) and during alveolar hypoxia (3)(4)(5)(6). They may also be important mediators of the hemodynamic changes occumng in the adult respiratory distress syndrome (7), endotoxic shock (8)(9)(10)(11)(12)(13)(14), and the syndrome of persistent pulmonary hypertension of the newborn (15).…”
mentioning
confidence: 99%
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“…The leukotrienes are thought to play a role in sustaining high pulmonary vascular resistance because leukotriene receptor blockers decrease pulmonary vascular resistance in newborn lambs (20) and in adult sheep (13) subjected to acute alveolar hypoxia. Leukotrienes have also been found in tracheal washings of human newborns with persistent pulmonary hypertension (21).…”
Section: Discussionmentioning
confidence: 99%
“…Under local anesthesia, a fetal right upper (thromboxane AZ, PGF2, PGD2) (1-4) and lipoxygenase (leuko-pedal artery was cannulated. The fetus was intubated through a trienes C4 and D4) (1,(5)(6)(7)(8) pathways, have been implicated in tracheotomy with a 4.5 Fr cuffed endotracheal tube. Sheep mediating hypoxic pulmonary vasoconstriction in adult rats, surfactant, prepared from lung lavages of healthy adult sheep as newborn lambs, and human infants.…”
Section: Surgical Preparation Surgery Was Performed On Six Time-datedmentioning
confidence: 99%