Leukotriene-mediated sex dimorphism in murine asthma-like features during allergen sensitization

Rossi, Antonietta; Roviezzo, Fiorentina; Sorrentino, Rosalinda; Riemma, Maria Antonietta; Cerqua, Ida; Bilancia, Rossella; Spaziano, Giuseppe; Troisi, Fabiana; Pinto, Aldo; D’Agostino, Bruno; Werz, Oliver; Cirino, Giuseppe

doi:10.1016/j.phrs.2018.11.024

Cited by 21 publications

(33 citation statements)

References 45 publications

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“…than elderly men (67). Such sex-bias was evident also in mice and rats in vivo, where female animals in zymosan-induced peritonitis, carrageenan-elicited pleurisy or experimental models of inflammation upon allergen challenge produced higher levels of LTs (23,55,56).…”

Section: Sex Differences In Inflammation and In Autoimmune Diseasesmentioning

confidence: 89%

“…Also, in urine samples from healthy white volunteers, higher concentrations of 5-LOX products were found in samples from elderly women than elderly men ( 67 ). Such sex-bias was evident also in mice and rats in vivo , where female animals in zymosan-induced peritonitis, carrageenan-elicited pleurisy or experimental models of inflammation upon allergen challenge produced higher levels of LTs ( 23 , 55 , 56 ).…”

Section: Sex Bias In Prostaglandin and Leukotriene Biosynthesismentioning

confidence: 91%

“…Similarly, in asthmatic girls reaching puberty, montelukast clearly reduced asthma incidence vs. placebo, but not so in boys of the same age, even though montelukast was highly active in boys before puberty ( 73 ). Along these lines, superior therapeutic efficacy of different types of clinically relevant LT modifiers like zileuton, MK886 and montelukast were observed in female ovalbumin-sensitized BALB/c mice ( 56 ). Recent data showed that FLAP inhibitors like MK886 have impaired efficiency in males which is caused by androgens.…”

Section: Sex Bias In Prostaglandin and Leukotriene Biosynthesismentioning

confidence: 96%

“…In fact, there is accumulating evidence suggesting that female sex is afflicted with higher LT biosynthesis and androgens were shown to lower LT levels in vitro and in vivo ( Table 1 ) ( 22 , 23 , 54 – 56 ). For example, blood or isolated monocytes and neutrophils from healthy adult women exhibited higher capacities to produce LTs upon stimulation ex vivo vs. men ( 22 , 23 , 54 ).…”

Section: Sex Bias In Prostaglandin and Leukotriene Biosynthesismentioning

confidence: 99%

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Impact of Androgens on Inflammation-Related Lipid Mediator Biosynthesis in Innate Immune Cells

Werz

2020

Front. Immunol.

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Rheumatoid arthritis, asthma, allergic rhinitis and many other disorders related to an aberrant immune response have a higher incidence and severity in women than in men. Emerging evidences from scientific studies indicate that the activity of the immune system is superior in females and that androgens may act as "immunosuppressive" molecules with inhibitory effects on inflammatory reactions. Among the multiple factors that contribute to the inflammatory response, lipid mediators (LM), produced from polyunsaturated fatty acids, represent a class of bioactive small molecules with pivotal roles in the onset, maintenance and resolution of inflammation. LM encompass pro-inflammatory eicosanoids and specialized pro-resolving mediators (SPM) that coexist in a tightly regulated balance necessary for the return to homeostasis. Innate immune cells including neutrophils, monocytes and macrophages possess high capacities to generate distinct LM. In the last decades it became more and more evident that sex represents an important variable in the regulation of inflammation where sex hormones play crucial roles. Recent findings showed that the biosynthesis of inflammation-related LM is sex-biased and that androgens impact LM formation with consequences not only for pathophysiology but also for pharmacotherapy. Here, we review the modulation of the inflammatory response by sex and androgens with a specific focus on LM pathways. In particular, we highlight the impact of androgens on the biosynthetic pathway of inflammation-related eicosanoids in innate immune cells.

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Section: Sex Differences In Inflammation and In Autoimmune Diseasesmentioning

confidence: 89%

Section: Sex Bias In Prostaglandin and Leukotriene Biosynthesismentioning

confidence: 91%

Section: Sex Bias In Prostaglandin and Leukotriene Biosynthesismentioning

confidence: 96%

Section: Sex Bias In Prostaglandin and Leukotriene Biosynthesismentioning

confidence: 99%

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Impact of Androgens on Inflammation-Related Lipid Mediator Biosynthesis in Innate Immune Cells

Werz

2020

Front. Immunol.

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“…Leukotrienes (LT) are lipid mediators with a pro-inflammatory role in asthma, and recently a sex disparity in their production during allergen sensitization has been demonstrated [36]. Particularly, allergen sensitization selectively increased pulmonary LT biosynthesis in female mice.…”

Section: Sex-specific Leukotriene Formation Is Causative For Sex mentioning

confidence: 99%

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5

et al. 2019

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A critical role for Macrophage-derived Cysteinyl-Leukotrienes in HIV-1 induced neuronal injury

Yuan,

Medders,

Sanchez

et al. 2024

Brain, Behavior, and Immunity

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Leukotriene-mediated sex dimorphism in murine asthma-like features during allergen sensitization

Cited by 21 publications

References 45 publications

Impact of Androgens on Inflammation-Related Lipid Mediator Biosynthesis in Innate Immune Cells

Impact of Androgens on Inflammation-Related Lipid Mediator Biosynthesis in Innate Immune Cells

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5

A critical role for Macrophage-derived Cysteinyl-Leukotrienes in HIV-1 induced neuronal injury

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