Leukotriene receptor antagonist reduces inflammation and alveolar bone loss in a rat model of experimental periodontitis

Moro, Marcella Goetz; Oliveira, Marilia D. S.; Santana, Maria M.; Jesus, Flavia Neto de; Feitosa, Karla Barroso; Teixeira, Simone Aparecida; Franco, Gilson César Nobre; Spolidório, Luís Carlos; Muscará, Marcelo Nícolas; Holzhausen, Marinella

doi:10.1002/jper.20-0718

Cited by 5 publications

(1 citation statement)

References 47 publications

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“…Indeed, BLT antagonists have exhibited anti-inflammatory activities in multiple experimental inflammation models, such as murine pemphigoid disease [ 187 ], experimental periodontitis [ 188 ]. It is feasible to conduct structure-activity relationship studies to identify more potent antagonists to diminish inflammation caused by endogenous hypoxic.…”

Section: Targeting the Critical Mediators In Endogenous Hypoxic To Co...mentioning

confidence: 99%

Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities

Wang

Sun

et al. 2022

Cells

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The global epidemic of obesity is tightly associated with numerous comorbidities, such as type II diabetes, cardiovascular diseases and the metabolic syndrome. Among the key features of obesity, some studies have suggested the abnormal expansion of adipose-tissue-induced local endogenous hypoxic, while other studies indicated endogenous hyperoxia as the opposite trend. Endogenous hypoxic aggravates dysfunction in adipose tissue and stimulates secretion of inflammatory molecules, which contribute to obesity. In contrast, hypoxic exposure combined with training effectively generate exogenous hypoxic to reduce body weight and downregulate metabolic risks. The (patho)physiological effects in adipose tissue are distinct from those of endogenous hypoxic. We critically assess the latest advances on the molecular mediators of endogenous hypoxic that regulate the dysfunction in adipose tissue. Subsequently we propose potential therapeutic targets in adipose tissues and the small molecules that may reverse the detrimental effect of local endogenous hypoxic. More importantly, we discuss alterations of metabolic pathways in adipose tissue and the metabolic benefits brought by hypoxic exercise. In terms of therapeutic intervention, numerous approaches have been developed to treat obesity, nevertheless durability and safety remain the major concern. Thus, a combination of the therapies that suppress endogenous hypoxic with exercise plans that augment exogenous hypoxic may accelerate the development of more effective and durable medications to treat obesity and comorbidities.

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Section: Targeting the Critical Mediators In Endogenous Hypoxic To Co...mentioning

confidence: 99%

Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities

Wang

Sun

et al. 2022

Cells

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A reliable deep-learning-based method for alveolar bone quantification using a murine model of periodontitis and micro-computed tomography imaging

Xi,

Ali,

Zhou

et al. 2024

Journal of Dentistry

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TRPC expression in human periodontal ligament cells and the periodontal tissue of periodontitis mice: a preliminary study

Kim,

Jeon

et al. 2023

Lab Anim Res

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Background Transient receptor potential canonical (TRPC) channels are non-selective cationic channels with permeability to Ca2+ and Na+. Despite their importance, there are currently few studies on TRPC in the periodontal ligament (PDL) and bone cells in the dental field. To provide biological information regarding TRPC in PDL cells and periodontal tissue, we evaluated TRPC channels expression in the osteoblast differentiation of PDL cells and periodontitis-induced tissue. Human PDL cells were cultured in osteogenic differentiation media for 28 days, and the expression of Runx2, osteocalcin (OCN), and TRPC1, 3, 4, and 6 was evaluated by real-time PCR. In ligature-induced periodontitis mice, the alveolar bone and osteoid areas, the osteoclast number, and the expression of Runx2, OCN, TRPC3, and TRPC6 was evaluated by H&E staining, TRAP staining, and immunohistochemistry, respectively. Results In the PDL cell differentiation group, TRPC6 expression peaked on day 7 and TRPC3 expression generally increased during differentiation. During the 28 days of periodontitis progression, alveolar bone loss and osteoclast numbers increased compared to the control group during the experimental period and the osteoid area increased from day 14. TRPC6 expression in the periodontitis group increased in the PDL area and in the osteoblasts compared to the control group, whereas TRPC3 expression increased only in the PDL area on days 7 and 28. Conclusions These results indicate changes of TRPC3 and TRPC6 expression in PDL cells that were differentiating into osteoblasts and in periodontitis-induced tissue, suggesting the need for research on the role of TRPC in osteoblast differentiation or periodontitis progression.

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Leukotriene receptor antagonist reduces inflammation and alveolar bone loss in a rat model of experimental periodontitis

Cited by 5 publications

References 47 publications

Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities

Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities

A reliable deep-learning-based method for alveolar bone quantification using a murine model of periodontitis and micro-computed tomography imaging

TRPC expression in human periodontal ligament cells and the periodontal tissue of periodontitis mice: a preliminary study

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