There are several conflicting beliefs about epilepsy, and public awareness about this disease varies widely among different countries. The present study aimed to determine public perception and attitude regarding different aspects of epilepsy in Jeddah, Saudi Arabia. In addition, we aim to identify the cultural and religious beliefs in Saudi Arabia associated with the causes and treatment of epilepsy. Methods: This is a cross-sectional study that was conducted between January 2018 and June 2018 in malls and public places in Jeddah, Saudi Arabia. This study utilized a self-administered questionnaire composed of 40 items. Results: A total of 1,940 individuals participated in the study, of which 1,675 participants (86.3%) had previously heard about epilepsy. Approximately 60% of the participants believed that epilepsy was caused by a brain disease and 17.1% believed that it is a genetic disease. Over 50% of the participants believed that epilepsy is treated with medications, 31.5% believed that it can be treated by the recitation of Quran, and 16.2% believed that it can be treated by surgery, while 10.2% believe that there is no treatment. Conclusions: The results of the present study suggest that awareness about epilepsy in the general public should be raised to avoid a negative impact on the patients, their families, their communities, and the healthcare system. Several misconceptions were identified, particularly in the etiology and management of the disease. Increased awareness will help in the early diagnosis, appropriate care, and management of the patients, and lead to better social acceptance. Dissemination of information about epilepsy through social media should be considered to reach a great proportion of the general public.