Level of dietary energy and 2,4-thiazolidinedione alter molecular and systemic biomarkers of inflammation and liver function in Holstein cows

Hosseini, Afshin; Salman, Mustafa; Zhou, Zheng; Drackley, J.K.; Trevisi, Erminio; Loor, Juan J.

doi:10.1186/s40104-017-0196-y

Cited by 3 publications

(2 citation statements)

References 75 publications

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“…In a study carried out in dry cows by Hosseini et al . (2017), injection of TZD increased β-carotene and α-tocopherol concentration in plasma, but only in cows receiving a high energy diet. Our goats had relatively low dietary energy, more similar to the control group in Hosseini et al .…”

Section: Discussionmentioning

confidence: 92%

“…Our goats had relatively low dietary energy, more similar to the control group in Hosseini et al . (2017), nevertheless, an effect of TZD on the level of blood retinol, β-carotene and α-tocopherol was still observed. In particular, in the first experiment TZD-treated goats had reduced retinol but increased α-tocopherol and β-carotene after 19 d of TZD injections (or 12 d post-IMI).…”

Section: Discussionmentioning

confidence: 98%

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Effects of 2,4-thiazolidinedione (TZD) on milk fatty acid profile and serum vitamins in dairy goats challenged with intramammary infusion of Streptococcus uberis

Tsai

Rosa

Bionaz

et al. 2020

Journal of Dairy Research

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The study included two experiments. In the first, 24 lactating Saanen dairy goats received low-energy diet without vitamin supplements. Twelve goats received a daily IV injection of 2,4- thiazolidinedione (TZD), others received saline injection. A week later, 6 goats from each treatment were challenged with intramammary infusion (IMI) of saline (CTRL) or Streptococcus uberis. In the second experiment, 12 Saanen lactating dairy goats received supplemental vitamins to reach NRC recommendation level. Six goats in each group were injected with TZD or saline daily, and 14 d later received Streptococcus uberis IMI in the right half of the udder. The hypotheses were (1) TZD does not affect the level of retinol in blood, and (2) the fatty acid profile is affected by the interaction between mammary infection and TZD in dairy goats. In the first experiment blood samples were collected on d −7, −2, 1, 2, 12 and milk samples were collected on d −8, 1, 4, 7, and 12, both relative to IMI. In the second experiment, blood samples were collected on d −15, 0, 1, and 10 relative to IMI. Milk and serum samples were analyzed for retinol, α-tocopherol and fatty acid profile. Serum retinol and β-carotene concentrations were higher in the second experiment compared to the first. Serum β-carotene and α-tocopherol were greater in TZD than CTRL and there was a TZD × time interaction in the first experiment. In addition, the TZD × time interaction showed that the milk fatty acid were reduced in C16 : 0 while C18 : 3 n3 while total omega 3 fatty acids were increased, as well as with minor effect on preventing a transient increase in α-tocopherol in milk. Overall, the TZD may affect the lipid-soluble vitamins and fatty acid profile, potentially altering immune responses, during mastitis in dairy goats.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Effects of 2,4-thiazolidinedione (TZD) on milk fatty acid profile and serum vitamins in dairy goats challenged with intramammary infusion of Streptococcus uberis

Tsai

Rosa

Bionaz

et al. 2020

Journal of Dairy Research

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17β-estradiol rescues the damage of thiazolidinedione on chicken Sertoli cell proliferation via adiponectin

Zhang

Shi

et al. 2022

Ecotoxicology and Environmental Safety

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Molecular characterisation, temporal expression and involvement of ANGPTL4 in fat deposition in Muscovy ducks

Zhu

Lyu

Wang

et al. 2022

British Poultry Science

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Level of dietary energy and 2,4-thiazolidinedione alter molecular and systemic biomarkers of inflammation and liver function in Holstein cows

Abstract: Background: The objective of the study was to evaluate the effect of overfeeding a moderate energy diet and a 2,4-thiazolidinedione (TZD) injection on blood and hepatic tissue biomarkers of lipid metabolism, oxidative stress, and inflammation as it relates to insulin sensitivity.

Cited by 3 publications

References 75 publications

Effects of 2,4-thiazolidinedione (TZD) on milk fatty acid profile and serum vitamins in dairy goats challenged with intramammary infusion of Streptococcus uberis

Effects of 2,4-thiazolidinedione (TZD) on milk fatty acid profile and serum vitamins in dairy goats challenged with intramammary infusion of Streptococcus uberis

17β-estradiol rescues the damage of thiazolidinedione on chicken Sertoli cell proliferation via adiponectin

Molecular characterisation, temporal expression and involvement of ANGPTL4 in fat deposition in Muscovy ducks

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