Cardiovascular Diseases (CVD) are perceived a leading cause of death globally. Scientists and clinicians still search for more efficient prevention, treatment, rehabilitation and care programs suitable for patients with CVD. Common social awareness and interdisciplinary effort may significantly improve current situation, but the problem is more complex. This chapter, based on research and own experiences of authors, tries to answer the question: how maximize professional resources and optimize outcomes in clinical practice. Aim of this chapter is discuss current issues which may potentially influence efficiency of CVD prevention and therapy, including prevention, modifiable and non-modifiable risk factors, ways of cardiac rehabilitation (CR) and cardiac telerehabilitation (CTR), influence of researcher-subject relationship and patient-therapist relationship as far as placebo effect.