Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham Study

McAlindon, Timothy E.; Wilson, Peter W.F.; Aliabadi, Piran; Weissman, Barbara; Felson, David T.

doi:10.1016/s0002-9343(98)00413-6

Cited by 226 publications

(171 citation statements)

References 31 publications

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“…These 2 aforementioned studies not only found no increased risk of OA, but also suggested the possibility of disease protection. In contrast, another study found that elderly adults who self reported high levels of heavy physical activity had an increased risk of radiographic knee OA (12). In this latter study, the only study with a large number of overweight persons, body mass index (BMI) above the median was found to further increase the risk of knee OA among those who exercised.…”

Section: Introductionmentioning

confidence: 69%

“…One of these (12), from a different study sample in the Framingham Study (the original cohort), suggested that self-reported high levels of physical activity were associated with incident radiographic disease, especially in overweight persons. Although this increase in risk was impressive for heavy activity (OR 13.0 for both high BMI and heavy physical activity versus OR 2.1 for lowest tertile of BMI and heavy activity), the difference in risk by weight did not reach statistical significance, given the small numbers of cases.…”

Section: Discussionmentioning

confidence: 99%

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Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: The Framingham Study

Felson

Niu

Clancy

et al. 2007

Arthritis & Rheumatism

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147

137

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Objective. To evaluate the long-term effect of recreational exercise on the development of knee osteoarthritis (OA) in a community-based cohort of older adults, many of whom were overweight or obese. Methods. Subjects were asked about recreational activities including walking or jogging for exercise and working up a sweat, and were asked to compare their activity levels with others. Subjects were then asked about knee pain and weight-bearing anteroposterior and lateral knee radiographs were obtained. Approximately 9 years later, subjects were reexamined for OA. Radiographs were read for OA features in both tibiofemoral and patellofemoral compartments and were scored for tibiofemoral joint space narrowing. To evaluate incident OA, we excluded knees with OA at baseline for all analyses and focused on 3 knee-specific outcomes: incident radiographic OA, symptomatic OA, and tibiofemoral joint space loss. After adjusting for age, sex, body mass index (BMI), knee injury history, and correlation between knees, we evaluated the association of each recreational activity with OA development. Results. A total of 1,279 subjects underwent both baseline and followup examinations (mean age at baseline 53.2 years). Neither recreational walking, jogging, frequent working up a sweat, nor high activity levels relative to peers were associated with a decrease or increase in risk of OA. Joint space loss was also unaffected by activity. Persons with BMI above the median (27.7 kg/m 2 for men and 25.7 kg/m 2 for women; mean BMI >30 kg/m 2 for both) had no increases in risk of OA by different type of activity. Conclusion. Among middle-aged and elderly persons without knee OA, many of whom were overweight, recreational exercise neither protects against nor increases risk of knee OA.

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Section: Introductionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: The Framingham Study

Felson

Niu

Clancy

et al. 2007

Arthritis & Rheumatism

Self Cite

147

137

View full text Add to dashboard Cite

show abstract

“…Response options were "no," "one knee," or "both knees." Levels of habitual physical activity were estimated from a validated questionnaire, described by Kannel and Sorlie (24), assessing hours spent at different levels of activity (25). The number of hours reported at each level was weighted and summed, generating a theoretical range from 24 to 120 (24).…”

Section: Confoundersmentioning

confidence: 99%

Positive association between serum 25‐hydroxyvitamin D level and bone density in osteoarthritis

Bischoff‐Ferrari¹,

Kiel²,

Felson³

2005

Arthritis & Rheumatism

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“…6,7 Some studies support the thesis that running and a high physical activity can lead to early onset of OA. 8,9 However, other studies revealed divergent results with no effect or even describe a protective effect on the onset of OA in physically active people. 10,11 In recent years, MRI techniques (T1rho, dGEMRIC, T 2 and T 2 *) have led to a high interest in quantitative biochemical evaluation of the articular cartilage.…”

Section: Introductionmentioning

confidence: 99%

The immediate effect of long-distance running onT₂andT₂* relaxation times of articular cartilage of the knee in young healthy adults at 3.0 T MR imaging

Behzadi¹,

Welsch²,

Laqmani³

et al. 2016

BJR

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Cite this article as: Behzadi C, Welsch GH, Laqmani A, Henes FO, Kaul MG, Schoen G, et al. The immediate effect of long-distance running on T 2 and T 2 * relaxation times of articular cartilage of the knee in young healthy adults at 3.0 T MR imaging. Br J Radiol 2016; 89: 20151075. FULL PAPERThe immediate effect of long-distance running on T 2 and T 2 * relaxation times of articular cartilage of the knee in young healthy adults at 3. Objective: To quantitatively assess the immediate effect of long-distance running on T 2 and T 2 * relaxation times of the articular cartilage of the knee at 3.0 T in young healthy adults. Methods: 30 healthy male adults (18-31 years) who perform sports at an amateur level underwent an initial MRI at 3.0 T with T 2 weighted [16 echo times (TEs): 9.7-154.6 ms] and T 2 * weighted (24 TEs: 4.6-53.6 ms) relaxation measurements. Thereafter, all participants performed a 45-min run. After the run, all individuals were immediately re-examined. Data sets were post-processed using dedicated software (ImageJ; National Institute of Health, Bethesda, MD). 22 regions of interest were manually drawn in segmented areas of the femoral, tibial and patellar cartilage. For statistical evaluation, Pearson product-moment correlation coefficients and confidence intervals were computed. Results:Mean initial values were 35.7 ms for T 2 and 25.1 ms for T 2 *. After the run, a significant decrease in the mean T 2 and T 2 * relaxation times was observed for all segments in all participants. A mean decrease of relaxation time was observed for T 2 with 4.6 ms (63.6 ms) and for T 2 * with 3.6ms (65.1 ms) after running. Conclusion: A significant decrease could be observed in all cartilage segments for both biomarkers. Both quantitative techniques, T 2 and T 2 *, seem to be valuable parameters in the evaluation of immediate changes in the cartilage ultrastructure after running. Advances in knowledge: This is the first direct comparison of immediate changes in T 2 and T 2 * relaxation times after running in healthy adults.

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Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham Study

Cited by 226 publications

References 31 publications

Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: The Framingham Study

Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: The Framingham Study

Positive association between serum 25‐hydroxyvitamin D level and bone density in osteoarthritis

The immediate effect of long-distance running onT₂andT₂* relaxation times of articular cartilage of the knee in young healthy adults at 3.0 T MR imaging

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Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham Study

Cited by 226 publications

References 31 publications

Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: The Framingham Study

Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: The Framingham Study

Positive association between serum 25‐hydroxyvitamin D level and bone density in osteoarthritis

The immediate effect of long-distance running onT2andT2* relaxation times of articular cartilage of the knee in young healthy adults at 3.0 T MR imaging

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The immediate effect of long-distance running onT₂andT₂* relaxation times of articular cartilage of the knee in young healthy adults at 3.0 T MR imaging