Level of pleural invasion effects on prognosis in lung cancer

Tanju, Serhan; Erus, Suat; Selçukbiricik, Fatih; Iliaz, Sinem; Kapdağlı, Murat; Bulutay, Pınar; Sevinç, Tolga Evrim; Mandel, Nil Molınas; Dilege, Şükrü

doi:10.1177/0300891618792463

Cited by 13 publications

(6 citation statements)

References 14 publications

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“…[ 14 ] In addition, PI has been reported as a prognostic factor for OS in patients undergoing surgical resection. [ 25 ] Regarding CSS, in addition to GNRI, age, TNM stage, and PI were determinants of CSS. The results of the present study are similar to those of a previous study by Hino et al, which showed that age and TNM stage were significant determinants in multivariate Cox regression.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the geriatric nutritional risk index and the prognostic nutritional index in determining survival outcome in patients with non-small cell lung cancer undergoing surgical resection: A cohort study

An¹,

Han²,

Eo³

et al. 2022

Medicine

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To assess the clinical feasibility of the geriatric nutritional risk index (GNRI) and prognostic nutritional index (PNI) as determinants of survival in patients with stage I to III non-small cell lung cancer (NSCLC). This retrospective study included patients with stage I to III NSCLC from all age groups. Hazard ratios (HRs) for overall survival (OS), cancer-specific survival (CSS), and relapse-free survival (RFS) were calculated using the Cox regression analysis. The concordance index (C-index) of the models was evaluated following the establishment of the prognostic models for survival. The median patient age was 69 years, and 64.6% of the patients were male. In total, 172 (65.4%) patients were classified as having stage I disease, 52 (19.8%) as stage II disease, and 39 (14.8%) as stage III disease. Using multivariate Cox regression analysis, the HRs of GNRI for OS, CSS, and RFS were 0.37 (P = .003), 0.47 (P = .041), and 0.38 (P < .001), respectively. However, the HRs of the PNI for survival outcomes were not statistically significant. Overall, age, sex, tumor-node-metastasis (TNM) stage, pleural invasion (PI), and GNRI were significant determinants of OS and constituted the OS model (concordance index [C-index], 0.824). In addition, age, TNM stage, PI, and GNRI were significant determinants of CSS and constituted the CSS model (C-index, 0.828). Finally, TNM stage, PI, lymphatic invasion, and GNRI were significant determinants of RFS and constituted the RFS model (C-index, 0.783). Our study showed that GNRI, but not PNI, was a predictor of OS, CSS, and RFS in patients with stage I-III NSCLC across all age groups. Excellent discriminant power was observed for OS, CSS, and RFS models.Abbreviations: ALB = serum albumin level, ALC = absolute lymphocyte count, BMI = body mass index, BW = body weight, C-index = concordance index, CSS = cancer-specific survival, GNRI = geriatric nutritional risk index, HR = hazard ratio, LI = lymphatic invasion, LMR = lymphocyte-to-monocyte ratio, NSCLC = non-small cell lung cancer, OS = overall survival, PI = pleural invasion, PLR = platelet-to-lymphocyte ratio, PNI = prognostic nutritional index, TNM = tumor-node-metastasis, VI = vascular invasion, VIF = variance inflation factor.

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Section: Discussionmentioning

confidence: 99%

Comparison of the geriatric nutritional risk index and the prognostic nutritional index in determining survival outcome in patients with non-small cell lung cancer undergoing surgical resection: A cohort study

An¹,

Han²,

Eo³

et al. 2022

Medicine

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“…The optimal extent of lymph node clearance varies depending on the presence of VPI, with VPI(+) tumors necessitating a more extensive lymph node dissection compared to VPI(-) tumors of the same T1 size ( 55 ). However, it has also been demonstrated that the existence of VPI does not demonstrate a substantial correlation with lymph node involvement ( 56 ).…”

Section: Visceral Pleural Invasion and Lymph Node Involvementmentioning

confidence: 99%

“…Additionally, they observed no difference in prognosis among the PL1, PL2, and PL3 groups. However, it was also demonstrated that patients with PL0 and PL1 degrees of VPI exhibited similar survival rates, suggesting that these two groups could be considered negative for VPI, while the PL2 group had an impact on patient survival ( 56 ).…”

Section: Visceral Pleural Invasion and Prognosis And Survivalmentioning

confidence: 99%

Diagnosis, treatment, and prognosis of stage IB non-small cell lung cancer with visceral pleural invasion

Ruan,

Zhuo,

2024

Front. Oncol.

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With the increasing implementation of early lung cancer screening and the increasing emphasis on physical examinations, the early-stage lung cancer detection rate continues to rise. Visceral pleural invasion (VPI), which denotes the tumor’s breach of the elastic layer or reaching the surface of the visceral pleura, stands as a pivotal factor that impacts the prognosis of patients with non-small cell lung cancer (NSCLC) and directly influences the pathological staging of early-stage cases. According to the latest 9th edition of the TNM staging system for NSCLC, even when the tumor diameter is less than 3 cm, the final T stage remains T2a if VPI is present. There is considerable controversy within the guidelines regarding treatment options for stage IB NSCLC, especially among patients exhibiting VPI. Moreover, the precise determination of VPI is important in guiding treatment selection and prognostic evaluation in individuals with NSCLC. This article aims to provide a comprehensive review of the current status and advancements in studies pertaining to stage IB NSCLC accompanied by VPI.

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“…Moreover, parietal pleural adhesion/invasion increases surgical difficulty. Chemotherapy regimens also depend on the pleural invasion stage of lung cancer ( 8 , 9 ). Hence, precise preoperative identification of parietal pleural invasion is essential.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of parietal pleural adhesion and invasion in subpleural lung cancer: value of B-mode ultrasound and contrast-enhanced ultrasound

Zhang,

Liao

et al. 2024

Quant Imaging Med Surg

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Background The parietal pleural adhesion/invasion of lung cancer can contribute substantially to poor prognosis and difficulty in surgery. The value of ultrasound in evaluating the parietal pleural adhesion or invasion (pleural adhesion/invasion) of lung cancer remains uncertain. This study investigated the value of B-mode ultrasound and contrast-enhanced ultrasound (CEUS) in diagnosing parietal pleural adhesion/invasion of subpleural lung cancer. Methods The study animals included 40 male New Zealand white rabbits. A rabbit subpleural lung cancer model was constructed by injecting VX2 tumor tissue under ultrasound guidance. In the 1–3 weeks after subpleural lesion formation, parietal pleural adhesion/invasion of the largest subpleural lesion was evaluated with B-mode ultrasound and CEUS by two sonographers. The parietal pleural adhesion/invasion was also determined using the gold standard method of findings from anatomical and pathological examination. Results Ultimately, 34 rabbits were subjected to complete ultrasonic evaluation. There were 20 and 14 cases with and without parietal pleural adhesion/invasion, respectively, as confirmed by anatomical and pathological evaluations. The diagnostic sensitivity, specificity, and accuracy of sonographer 1 using B-mode ultrasound were 50.0% [95% confidence interval (CI): 26.0–74.0%], 100%, and 70.6% (95% CI: 54.5–86.7%), respectively; for CEUS, they were 90.0% (95% CI: 75.6–100.0%), 100.0%, and 94.1% (95% CI: 85.8–100.0%), respectively. The diagnostic sensitivity, specificity, and accuracy of sonographer 2 using B-mode ultrasound were 45.0% (95% CI: 21.1–68.9%), 92.9% (95% CI: 77.5–100.0%), and 64.7% (95% CI: 47.8–81.6%), respectively; for CEUS, they were 85.0% (95% CI: 67.9–100.0%), 100.0%, and 91.2% (95% CI: 81.1–100.0%), respectively. The diagnostic accuracy of sonographer 1 was higher with CEUS than with B-mode ultrasound, but not significantly so (94.1% vs. 70.6%; P=0.08). The diagnostic accuracy of sonographer 2 was significantly higher with CEUS than with B-mode ultrasound (91.2% vs. 64.7%; P=0.03). The interrater reliability was higher for CEUS than for B-mode ultrasound (κ=0.941 vs. κ =0.717). Conclusions Based on an animal model, B-mode ultrasound and CEUS both exhibited good diagnostic efficacy and interrater reliability in evaluating parietal pleural adhesion/invasion of subpleural lung cancer although CEUS outperformed B-mode ultrasound for both measures.

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Level of pleural invasion effects on prognosis in lung cancer

Cited by 13 publications

References 14 publications

Comparison of the geriatric nutritional risk index and the prognostic nutritional index in determining survival outcome in patients with non-small cell lung cancer undergoing surgical resection: A cohort study

Comparison of the geriatric nutritional risk index and the prognostic nutritional index in determining survival outcome in patients with non-small cell lung cancer undergoing surgical resection: A cohort study

Diagnosis, treatment, and prognosis of stage IB non-small cell lung cancer with visceral pleural invasion

Evaluation of parietal pleural adhesion and invasion in subpleural lung cancer: value of B-mode ultrasound and contrast-enhanced ultrasound

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