Level of uric acid and uric acid/creatinine ratios in correlation with stage of Parkinson disease

Zhong, Lingling; Song, Yu; Tian, Xiangyang; Cao, Hua; Ju, Keju

doi:10.1097/md.0000000000010967

Cited by 26 publications

(25 citation statements)

References 25 publications

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“…We were unable to find evidence in support of the recent finding in a smaller sample (Zhong et al 2018) of a relationship between HY stage and UA levels. This may reflect other differences between the studies; our sample was generally less severe, with no patients of HY stage greater than 3, and untreated.…”

Section: Discussioncontrasting

confidence: 99%

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Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease

et al. 2019

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Monoamine oxidase type B inhibitors act in Parkinson's disease (PD) via potentiation of dopamine, but may also have neuroprotective effects by reducing oxidative damage. Oxidative damage is also a feature of environmental toxins, including pesticides, that are an established risk factor for PD. Another risk factor is low circulating uric acid (UA), which may relate to UA being the major endogenous antioxidant in the human body. We have undertaken a study of 192 initial admissions for PD in a general hospital neurology department in a partly rural region of Southern China to determine if there is an increased rate of PD in agricultural workers who have a high risk of exposure to pesticides, and how it may relate to deficits in UA. We found a disproportionately high number of agricultural workers admitted with PD (66.7% vs. 54.3% of all neurology admissions) and that PD subjects have a substantial reduction in UA. This is further reduced in agricultural workers and thus may contribute to the increased vulnerability of this group to PD.

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Section: Discussioncontrasting

confidence: 99%

“…This may reflect other differences between the studies; our sample was generally less severe, with no patients of HY stage greater than 3, and untreated. Another study of 80 PD patients also showed greater reduction in UA with disease severity and, in contrast to Zhong et al (2018), with levodopa treatment (Vieru et al 2016).…”

Section: Discussionmentioning

confidence: 89%

Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease

et al. 2019

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“…This condition induces gout and accelerates the progression of renal and cardiovascular diseases [1–3]. On the other hand, UA exerts antioxidant activity in our body and many reports have shown a correlation between UA levels and reduced risk or favorable progression of neurogenerative diseases [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical analysis of uric acid excretion to the intestinal lumen: Effect of serum uric acid-lowering drugs and 5/6 nephrectomy on intestinal uric acid levels

et al. 2019

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Recently, extensive efforts have been made to understand the importance of the extra-renal uric acid (UA) excretion pathways and their contribution to UA-related diseases. However, the method typically used to measure UA concentrations in the intestinal lumen is difficult to real time and dynamic analysis. In this study, UA excretion in the rat intestinal lumen was measured in real time using an electrochemical method. A sensitive electrode to detect UA was constructed using a gold electrode modified with a mixed self-assembled monolayer. Excretion rate of UA in the intestine was calculated using time course data. A decrease in UA excretion rate was observed in the intestine after administration of serum UA-lowering drugs (benzbromarone, febuxostat, and topiroxostat). Inhibition of ATP-binding cassette transporter G2 (ABCG2) which has been reported as an important exporter of UA was suggested by administration of these drugs. On the other hand, an increase in excretion rate of UA was observed in the intestine of 5/6 nephrectomy rats. Upregulation of mRNA expression of the UA transporter organic anion transporter OAT3, which is related to the secretion at the basal membrane, suggested an enhancement of UA excretion by ABCG2, a high-capacity UA exporter. Observed urate excretion dynamics and mRNA expression of UA transporters in the intestine upon administration of serum UA-lowering drugs and 5/6 nephrectomy improve our understanding of the underlying mechanisms of intestinal UA excretion.

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“…Homocysteine, uric acid (UA), albumin, and bilirubin are defined as laboratory parameters associated with oxidative stress. Low UA, albumin, and bilirubin concentrations were associated with many neurodegenerative diseases, including PD, but these changes in their concentrations as oxidative stress markers were not clarified as to whether they caused neurodegenerative diseases or they were results of the underlying process in the literature (7,17,18,19,20,21,22). Several studies showed that there was a correlation between hypoalbuminemia and increased CRP concentrations and other acute phase proteins (34).…”

Section: Discussionmentioning

confidence: 99%

“…toxins, free radicals, dysfunctions in the ubiquitin/proteasome system) can lead dopaminergic cells to undergo apoptotic death (8,9). Serum C-reactive protein (CRP) and albumin concentrations have recently been used as markers of systemic inflammation and oxidative stress in different diseases (7,10,11,12,13,14,15,16,17,18,19,20,21,22).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of C-reactive Protein/Albumin Ratio According to Stage in Patients with Idiopathic Parkinson Disease

Yazar¹,

Yazar²

2019

tnd

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Objective: Identification of serum C-reactive protein (CRP)/albumin ratio according to disease stage in idiopathic Parkinson's disease (IPD) with the aim of collecting data about the role of inflammation and oxidative stress in etiopathogenesis and about CRP/albumin ratio's possible effects on disease progression. Materials and Methods: The study was completed with 151 patients being staged according to the Modified Hoehn and Yahr (H&Y) criteria and 150 healthy volunteers in the same age interval with patients. In our retrospective study, the Unified Parkinson disease rating scale (UPDRS) and H&Y scales were applied to the patients with IPD diagnosed according to the diagnostic criteria of the "United Kingdom Parkinson Disease Society Brain Bank". Patient and control groups had venous blood samples taken for biochemical study after 12-14 hours of fasting. Results: The serum albumin levels were lower, while serum CRP levels and CRP/albumin ratios were higher in the IPD group (p<0.05) than in the control group. Serum levels of CRP/albumin ratio significantly increased in parallel with the progression of disease stage (p<0.05). Conclusion: Our study supports the hypothesis that serum CRP/albumin ratio may be associated with the etiopathogenetic process of IPD as a biomarker of inflammation and oxidative stress. In order to detect chronic and progressive diseases such as IPD in the initial stages and to take precautions, it is important to evaluate the changes in easily accessible, cost-effective parameters such as serum CRP/albumin ratio.

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Level of uric acid and uric acid/creatinine ratios in correlation with stage of Parkinson disease

Cited by 26 publications

References 25 publications

Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease

Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson’s disease

Electrochemical analysis of uric acid excretion to the intestinal lumen: Effect of serum uric acid-lowering drugs and 5/6 nephrectomy on intestinal uric acid levels

Evaluation of C-reactive Protein/Albumin Ratio According to Stage in Patients with Idiopathic Parkinson Disease

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