Levels and Distribution of PCBs and Organochlorine Pesticides in the Air, Pine Needles, and Human Milk

Kožul, Darija; Romanić, Snježana Herceg

doi:10.2478/10004-1254-61-2010-2007

Cited by 4 publications

(1 citation statement)

References 85 publications

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“…9 Investigators have reported that 3,3,4-tetrachlorobipherryl (IUPAC number PCB-77), 3,3,4,4,5-pentachlorobiphenyl (PCB-126), and 3,3,4,4,5,5-hexachlorobiphenyl (PCB-169) produce the following toxic and biological effects in some species of animals: body weight loss, dermal disorder, reproductive toxicity, and immunotoxicity. 10 The present study is the first, to our knowledge, to evaluate the mechanisms behind PCBs exposure and spontaneous abortion.…”

Section: Introductionmentioning

confidence: 84%

Endocrine Disruptors, Polychlorinated Biphenyls-Induced gC1qR-dependent Apoptosis in Human Trophoblast Cell Line HTR-8/SVneo

Gao

et al. 2012

Reprod. Sci.

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Although an association exists between exposure to polychlorinated biphenyls (PCBs) and spontaneous miscarriage, the mechanisms underlying this phenomenon remain unclear. In this study, PCBs content in plasma was detected by gas chromatography-mass spectrometry (GC-MS) and decidua tissues were examined for the expression of globular heads of C1q receptor (gC1qR) using Western blot in patients who underwent induced abortion and spontaneous abortion. Results showed increased PCBs content and gC1qR expression in patients who experienced spontaneous abortion. In vitro, Western blot analysis demonstrated significantly higher caspase 3 expression and apoptotic cell counts in green fluorescent protein (GFP)-gC1qR vector group. Additionally, gC1qR and caspase 3 showed decreased expression following PCBs plus gC1qR small interfering RNA (siRNA) treatment. The percentage of apoptotic cells increased in cells treated with PCBs alone or PCB plus negative siRNA. These data suggest that maternal exposure to PCBs is associated with adverse pregnancy outcomes and that upregulation of gC1qR is important for PCBs-mediated trophoblast cell apoptosis.

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Section: Introductionmentioning

confidence: 84%

Endocrine Disruptors, Polychlorinated Biphenyls-Induced gC1qR-dependent Apoptosis in Human Trophoblast Cell Line HTR-8/SVneo

Gao

et al. 2012

Reprod. Sci.

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Organochlorinated Contaminants in General Population of Argentina and Other Latin American Countries

Ridolfi

Alvarez

Girault

2014

Bioremediation in Latin America

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Spatial and temporal trends of the Stockholm Convention POPs in mothers’ milk — a global review

Fång

Nyberg

Winnberg

et al. 2015

Environ Sci Pollut Res

106

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Persistent organic pollutants (POPs) have been of environmental and health concern for more than half a century and have their own intergovernmental regulation through the Stockholm Convention, from 2001. One major concern is the nursing child’s exposure to POPs, a concern that has led to a very large number of scientific studies on POPs in mothers’ milk. The present review is a report on the assessment on worldwide spatial distributions of POPs and of their temporal trends. The data presented herein is a compilation based on scientific publications between 1995 and 2011. It is evident that the concentrations in mothers’ milk depend on the use of pesticides and industrial chemicals defined as POPs. Polychlorinated biphenyls (PCBs) and “dioxins” are higher in the more industrialized areas, Europe and Northern America, whereas pesticides are higher in Africa and Asia and polybrominated diphenyl ethers (PBDEs) are reported in higher concentrations in the USA. POPs are consequently distributed to women in all parts of the world and are thus delivered to the nursing child. The review points out several major problems in the reporting of data, which are crucial to enable high quality comparisons. Even though the data set is large, the comparability is hampered by differences in reporting. In conclusion, much more detailed instructions are needed for reporting POPs in mothers’ milk. Temporal trend data for POPs in mothers’ milk is scarce and is of interest when studying longer time series. The only two countries with long temporal trend studies are Japan and Sweden. In most cases, the trends show decreasing concentrations of POPs in mothers’ milk. However, hexabromocyclododecane is showing increasing temporal concentration trends in both Japan and Sweden.

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Levels and Distribution of PCBs and Organochlorine Pesticides in the Air, Pine Needles, and Human Milk

Cited by 4 publications

References 85 publications

Endocrine Disruptors, Polychlorinated Biphenyls-Induced gC1qR-dependent Apoptosis in Human Trophoblast Cell Line HTR-8/SVneo

Endocrine Disruptors, Polychlorinated Biphenyls-Induced gC1qR-dependent Apoptosis in Human Trophoblast Cell Line HTR-8/SVneo

Organochlorinated Contaminants in General Population of Argentina and Other Latin American Countries

Spatial and temporal trends of the Stockholm Convention POPs in mothers’ milk — a global review

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