Nursing burnout has been linked to stress, anxiety, and depression. Increased stress and anxiety have been closely related to burnout. This study's major goal has been to determine the association of these variables in the context of nursing practice. This descriptive correlational study aimed at determining the relationship between stress, anxiety, and depression with burnout among the 307 purposive nurse samples from participating government and private hospitals in Manila, Pampanga, and Tarlac, Philippines collected between March and June 2020 using a 21-item Depression Anxiety Stress Scale (DASS-21) and a 16-item Oldenburg Burnout Inventory (OLBI) instruments. Mostly with a normal level of stress, anxiety, and depression, the nurses had been also found to have a moderate level of overall burnout and were moderately disengaged, and exhausted. Using IBM SPSS v.26, the study utilized Pearson product-moment correlation which found that nurses’ stress had significant relationships (p=.000) with burnout, disengagement, and exhaustion; anxiety to burnout, disengagement, and exhaustion; and depression with burnout, disengagement, and exhaustion. The degree of stress, anxiety, and depression has significantly shown direct correspondence which calls for a deeper examination of sources and factors. Nurses' experience of burnout is associated with the service-oriented features of the profession. The emphasis is on the need for treatments to guarantee that burnout does not lead to higher staff turnover, degraded health care, decreased productivity, and decreased professional fulfillment. A systems approach to burnout prevention and treatment should investigate the relevant factors that are addressed in the organizational, group, and individual efforts. This study offers a remarkable hypothetical underpinning for nurses' ability to handle stressful workplace situations with resilience and professionalism.