Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries

Jönsson, Lena; Broberg, Karin; Bergendorf, Ulf; Axmon, Anna; Littorin, Margareta; Jönsson, Bo

doi:10.1007/s00420-007-0171-6

Cited by 13 publications

(17 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and Poland (41,42); and half of the rubber workers in this study exceeded the German target value, the only available exposure limit (31). N-nitrosamines have been reported to induce oxidative stress and DNA damage (43)(44)(45)(46), and the main mechanism suggested for N-nitrosamine carcinogenesis is through the formation of DNA adducts that can cause mutations (47,48).…”

Section: Et Almentioning

confidence: 99%

“…The measured exposure levels and workers' biomarker levels, across different jobs and factories, have been published before for this study population [N-nitrosamines (29), 1-hydroxypyrene (1-HP) (30), and 2-thiothiazolidine-4-carboxylic acid (TTCA) (31)]. The exposure estimates were for N-nitrosamines, based on one air measurement per individual (N=60), and for the biomarkers in urine from one urinary sample per individual (N=157).…”

Section: Exposure Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

N–nitrosamines are associated with shorter telomere length

Li¹,

Jönsson²,

Lindh³

et al. 2011

Scand J Work Environ Health

Self Cite

View full text Add to dashboard Cite

Section: Et Almentioning

confidence: 99%

Section: Exposure Assessmentmentioning

confidence: 99%

N–nitrosamines are associated with shorter telomere length

Li¹,

Jönsson²,

Lindh³

et al. 2011

Scand J Work Environ Health

Self Cite

View full text Add to dashboard Cite

“…The companies, and the numbering thereof, are the same as in an earlier study by our group (11). The production profiles and methods of the eight companies participating in the study are shortly described below.…”

Section: Description Of Companiesmentioning

confidence: 99%

N-nitrosamines in the southern Swedish rubber industries – exposure, health effects, and immunologic markers

Jönsson¹,

Lindh²,

Bergendorf³

et al. 2009

Scand J Work Environ Health

Self Cite

View full text Add to dashboard Cite

“…They were employed at eight different rubber companies, which are described in detail elsewhere (Jönsson et al 2007a). The exposed workers did not use personal protection devices.…”

Section: Study Subjectsmentioning

confidence: 99%

“…In an earlier study by our group, urinary levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) were used as an index substance for the exposure in the rubber industry. TTCA is a marker for carbon disulfide as well as for vulcanization fumes in general (Jönsson et al 2007a). Some exposure-response relationships with symptoms (e.g.…”

Section: Introductionmentioning

confidence: 99%

Levels of 1-hydroxypyrene, symptoms and immunologic markers in vulcanization workers in the southern Sweden rubber industries

Jönsson

Broberg

Axmon

et al. 2008

Int Arch Occup Environ Health

Self Cite

View full text Add to dashboard Cite

Objectives The aim of this study was to determine urinary 1-hydroxypyrene (1-HP) levels in contemporary Swedish vulcanization workers and in controls. These levels were used as an index substance for vulcanization fumes, as well as a biomarker for polycyclic aromatic hydrocarbons (PAHs). The risk of symptoms and changed levels of immunologic markers were investigated in relation to the 1-HP levels.Methods Included in the study were 163 exposed workers and 106 controls. Medical and occupational histories were obtained by structured interviews. Symptoms were recorded and immunologic markers analysed in blood by routine analysis methods. Levels of 1-HP were determined by liquid chromatography and fluorescence detection.Results The highest levels of 1-HP were found among exposed workers using injection and compression vulcanization, and lower levels were found among exposed workers vulcanizing with salt bath, hot air, microwaves or fluid-bed. Compared to controls, exposed workers had increased risks of eye symptoms, nosebleeds, burning and dry throat, hoarseness, severe dry cough, nausea and headache. Furthermore, exposed workers had elevated levels of neutrophils and total IgG (immunoglobulin subclass G). However, only for severe dry cough an evident exposure-response relationship with urinary 1-HP levels was found.Conclusions This work clearly shows increased levels of urinary 1-HP in Swedish vulcanization workers. Furthermore, it demonstrates an increased risk of several symptoms and elevated levels of some immunologic markers in these workers. However, no obvious exposure-response relationships were found.

show abstract

Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries

Cited by 13 publications

References 24 publications

N–nitrosamines are associated with shorter telomere length

N–nitrosamines are associated with shorter telomere length

N-nitrosamines in the southern Swedish rubber industries – exposure, health effects, and immunologic markers

Levels of 1-hydroxypyrene, symptoms and immunologic markers in vulcanization workers in the southern Sweden rubber industries

Contact Info

Product

Resources

About