Levels of 25-hydroxyvitamin D3, biochemical parameters and symptoms of depression and anxiety in healthy individuals

Casseb, Gleicilaine Aparecida Sena; Ambrósio, Gabriela; Rodrigues, Ana Lúcia S.; Kaster, Manuella P.

doi:10.1007/s11011-018-0371-7

Cited by 11 publications

(7 citation statements)

References 66 publications

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“…Administrating 50000 IU vitamin D3 biweekly to individuals under MMT significantly attenuated the severity of anxiety and depression after 12 weeks [16]. However, as per Casseb et al, vitamin D3 levels were not significantly associated with anxiety and depression scores in healthy subjects [32]. Furthermore, there was no correlation between vitamin D levels and the severity of mental health disorders in individuals with fibromyalgia [33].…”

Section: Discussionmentioning

confidence: 98%

The Relationship Between Vitamin D Levels and the Severity of Anxiety and Depression in Patients Under Methadone Maintenance Treatment

Abdolahzade-Arani

Kahrizi

Ghaderi

et al. 2021

IJMTFM

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Background: Hypovitaminosis D, low bone mineral density, non-specific musculoskeletal pain, increased risk of fracture, and periodontal disease were reported in most subjects recruited from the Methadone Maintenance Treatment (MMT) program. This study aimed to determine the relationship between vitamin D levels and the severity of anxiety and depression in patients under MMT. Methods: In a cross-sectional study, serum vitamin D levels were measured among 500 patients under MMT from Kashan Province, Iran. Correlation tests were used to assess the association of vitamin D levels with the severity of anxiety and depression in the explored patients. Results: We found that serum vitamin D levels were positively correlated with the scores of the Beck Depression Inventory (BDI) (r=0.107, P=0.017) and the Beck Anxiety Inventory (BAI) (r=0.129, P=0.004). Additionally, there was a negative correlation between serum vitamin D levels, MMT dosage (r=-0.011, P=0.8), and the duration of MMT (r=-0.017, P=0.7). Conclusion: Our findings demonstrated that serum vitamin D levels were independently correlated with the BDI and BAI scores. Further studies are required to confirm our findings.

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Section: Discussionmentioning

confidence: 98%

The Relationship Between Vitamin D Levels and the Severity of Anxiety and Depression in Patients Under Methadone Maintenance Treatment

Abdolahzade-Arani

Kahrizi

Ghaderi

et al. 2021

IJMTFM

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“…[71][72][73] In healthy individuals, lowered vitamin D3 levels are associated with increased atherogenicity, IR, and depression (BDI) and anxiety scores. 74 Moreover, vitamin D3 supplementation may reduce angina attacks 67 and depressive symptoms. 29 Depressive symptoms, EOS, trace elements, macrominerals, and ATS/UA.…”

Section: Clinical Aspects Of the Comorbidity Of Depression And Ats/uamentioning

confidence: 99%

A pathway phenotype linking metabolic, immune, oxidative, and opioid pathways with comorbid depression, atherosclerosis, and unstable angina

et al. 2021

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Background There is strong comorbidity between atherosclerosis (ATS) and depression which is attributed to increased atherogenicity, insulin resistance (IR), and immune and oxidative stress. Aim of the study To examine the role of the above pathways and mu-opioid receptor (MOR), β-endorphin levels, zinc, copper, vitamin D3, calcium, and magnesium in depression due to ATS/unstable angina (UA). Methods Biomarkers were assayed in 58 controls and 120 ATS patients divided into those with moderate and severe depression according to the Beck Depression Inventory-II (BDI-II) scores >19 and >29, respectively. Results Neural network and logistic regression models showed that severe depression due to ATS/UA was best predicted by interleukin-6 (IL-6), UA, MOR, zinc, β-endorphin, calcium and magnesium, and that moderate depression was associated with IL-6, zinc, MOR, β-endorphin, UA, atherogenicity, IR, and calcium. Neural networks yielded a significant discrimination of severe and moderate depression with an area under the receiver operating curves of 0.831 and 0.931, respectively. Using Partial Least Squares path analysis, we found that 66.2% of the variance in a latent vector extracted from ATS/UA clinical features, and the BDI-II scores, atherogenicity, and IR could be explained by the regression on IL-6, IL-10, zinc, copper, calcium, MOR, and age. The BDI-II scores increased from controls to ATS to UA class III to UA class IV. Conclusions Immune activation, the endogenous opioid system, antioxidants, trace elements, and macrominerals modulate a common core shared by increased depressive symptoms, ATS, UA, atherogenicity, and IR.

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“…A deficiency in vitamin D3 is associated with slow coronary flow rate, increased risk of CVD/ATS, and worse prognosis of ATS (Huang et al, 2017;Meredith and McManus, 2013;Ramadan et al, 2014;Sagarad et al, 2016) and is detected in depression due to other medical illness including chronic kidney disease, traumatic brain injury, and chronic spinal cord injury (Barbonetti et al, 2017;Jamall et al, 2016;Jhee et al, 2017). In healthy individuals, lowered vitamin D3 levels are associated with increased atherogenicity, IR, and depression (BDI) and anxiety scores (Casseb et al, 2019). Moreover, vitamin D3 supplementation may reduce angina incidents (Sagarad et al, 2016) and depressive symptoms (Vellekkatt and Menon, 2019).…”

Section: Depressive Symptoms Immune and Oxidative Stress Biomarkers And Ats/uamentioning

confidence: 99%

A Nomothetic Network Model Disclosing the Comorbidity of Depression and Unstable Angina: Effects of Atherogenicity, Insulin Resistance, Immune Activation, Antioxidants, the Endogenous Opioid System, Trace Elements, and Macrominerals

Mousa¹,

Smesam²,

Qazmooz³

et al. 2020

Preprint

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Background. There is strong comorbidity between atherosclerosis (ATS) and depression which is attributed to increased atherogenicity, insulin resistance (IR), and immune and oxidative stress.Aim of the study. To examine the role of the above pathways and mu opioid receptor (MOR), β-endorphin, zinc, copper, vitamin D3, calcium, and magnesium in depression due to ATS / unstable angina (UA).Methods. Biomarkers were assayed in 58 controls and 120 ATS patients divided into those with moderate and severe depression according to the Beck Depression Inventory (BDI)-II score > 19 and > 29, respectively. Results. Neural network and logistic regression models showed that severe depression due to ATS/UA was best predicted by IL-6, UA, MOR, zinc, β-endorphin, calcium and magnesium and that moderate depression was associated with IL-6, zinc, MOR, β-endorphin, UA, atherogenicity, IR, and calcium. These neural networks yielded a significant discrimination of severe and moderate depression with an area under the ROC curve of 0.831 and 0.931, respectively. Using Partial Least Squares analysis, 66.2% of the variance in a latent vector extracted from the ATS/UA clinical features, BDI-II scores, atherogenicity, and IR could be explained by the regression on IL-6, IL-10, zinc, copper, calcium, MOR, and age. The BDI-II scores increased from controls to ATS to UA class III to UA class IV.Conclusions. Depression due to ATS/UA is a reflective manifestation of increased atherogenicity and IR, which are modulated by immune activation, aberrations in the endogenous opioid system, antioxidants, trace elements, and macrominerals.

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Levels of 25-hydroxyvitamin D3, biochemical parameters and symptoms of depression and anxiety in healthy individuals

Cited by 11 publications

References 66 publications

The Relationship Between Vitamin D Levels and the Severity of Anxiety and Depression in Patients Under Methadone Maintenance Treatment

The Relationship Between Vitamin D Levels and the Severity of Anxiety and Depression in Patients Under Methadone Maintenance Treatment

A pathway phenotype linking metabolic, immune, oxidative, and opioid pathways with comorbid depression, atherosclerosis, and unstable angina

A Nomothetic Network Model Disclosing the Comorbidity of Depression and Unstable Angina: Effects of Atherogenicity, Insulin Resistance, Immune Activation, Antioxidants, the Endogenous Opioid System, Trace Elements, and Macrominerals

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