Levels of acute inflammatory biomarkers in advanced prostate cancer patients with α2-macroglobulin deficiency

Kanoh, Yuhsaku; Ohtani, Hideki; Egawa, Shin; Baba, Shirō; Akahoshi, Tohru

doi:10.3892/ijo.2011.1185

Cited by 7 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We previously reported that serum levels of α2M-dependent acute inflammatory biomarkers such as CRP, SAA and IL-6 were decreased in PCa patients with α2M deficiency (17). In this study, serum IL-6 levels were within reference range in PCa patients with α2M deficiency.…”

Section: Discussionsupporting

confidence: 61%

“…We previously reported that the quantitative imbalance between proteases, such as PSA and matrix metalloproteinase-2, and their inhibitors, including α2M and α2-plasmin inhibitor, is a causative factor in invasion and metastasis of PCa (22). Furthermore, we showed a relationship between serum levels of α2M and acute inflammatory biomarkers such as IL-6 and CRP in PCa patients with or without α2M deficiency (17). We also previously reported on advanced PCa patients with multiple distant bone metastases in whom serum α2M levels were markedly decreased to <20 mg/dl (α2M deficiency) (1,2).…”

Section: Discussionmentioning

confidence: 71%

“…We previously reported on advanced PCa patients with multiple distant bone metastases in whom serum α2M levels were markedly decreased to <20 mg/dl (α2M deficiency) (1,2). We also showed a relationship between serum levels of α2M and acute inflammatory biomarkers in PCa patients with or without α2M deficiency (17). In this study, we analyzed in detail the clinicopathological characteristics and pathogenesis of α2M deficiency in androgen-dependent advanced PCa patients.…”

Section: Introductionmentioning

confidence: 84%

See 2 more Smart Citations

Clinicopathological characteristics of androgen-dependent advanced prostate cancer patients with α2-macroglobulin deficiency

et al. 2012

Self Cite

View full text Add to dashboard Cite

Abstract. α2-macroglobulin (α2M) is thought to be involved in cancer metastasis and inflammatory reaction through its functions as a proteinase inhibitor and carrier protein for interleukin-6 (IL-6). We previously reported that advanced prostate cancer (PCa) patients with multiple distant bone metastases had markedly decreased serum α2M levels (<20 mg/dl) and no detection of α2M by immunoelectrophoresis (defined as α2M deficiency). We also showed a relationship between serum α2M levels and acute inflammatory biomarkers in PCa patients with or without α2M deficiency. In this study, we analyzed in detail the clinicopathological characteristics and pathogenesis of α2M deficiency in androgen-dependent advanced PCa patients. In this study, 15 PCa patients were diagnosed at the Kitasato University Hospital. α2M levels were determined by laser-nephelometry and immunoelectrophoresis, and PSA levels were determined by enzyme immunoassay. IL-6 levels were measured by a specific luminescence sandwich-type enzyme-linked immunosorbent assay, and CRP levels were determined by latex nephelometry.

show abstract

Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 84%

See 1 more Smart Citation

Clinicopathological characteristics of androgen-dependent advanced prostate cancer patients with α2-macroglobulin deficiency

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…Abundance change of some of these proteins seems unique to the SFN+CQ combination. For example, abundance of alpha 1 acid glycoprotein, which is an acute inflammatory biomarker that increases in various conditions including malignancy (43), is decreased after SFN+CQ treatment (2.6-fold decrease compared with control) but its level increases in the plasma of SFN alone treated mice. We observed decreased abundance of kininogen-1 isoform 1 precursor and transthyretin precursor in the plasma of SFN+CQ-treated mice compared with control.…”

Section: Discussionmentioning

confidence: 99%

Chemoprevention of Prostate Cancer by d,l-Sulforaphane Is Augmented by Pharmacological Inhibition of Autophagy

et al. 2013

View full text Add to dashboard Cite

There is preclinical evidence that oral administration of D,L-sulforaphane (SFN) can decrease the incidence or burden of early-stage prostate cancer (PIN) and well-differentiated cancer (WDC), but not late-stage poorly differentiated cancer (PDC). Because SFN treatment induces cytoprotective autophagy in cultured human prostate cancer cells, the present study tested the hypothesis that chemopreventive efficacy of SFN could be augmented by pharmacological inhibition of autophagy using chloroquine (CQ). Incidence of PDC characterized by prostate weight of >1g was significantly lower in the SFN+CQ group compared with control (P=0.004), CQ (P=0.026) or SFN group (P=0.002 by Fisher’s exact test). Average size of the metastatic lymph-node was lower by about 42% in the SFN+CQ group compared with control (P=0.043 by Wilcoxon test). On the other hand, the SFN+CQ combination was not superior to SFN alone with respect to inhibition of incidence or burden of microscopic PIN or WDC. SFN treatment caused in vivo autophagy as evidenced by transmission electron microscopy. Mechanistic studies showed that prevention of prostate cancer and metastasis by the SFN+CQ was associated with decreased cell proliferation, increased apoptosis, alterations in protein levels of autophagy regulators Atg5 and phospho-mTOR, and suppression of biochemical features of epithelial-mesenchymal transition. Plasma proteomics identified protein expression signature that may serve as biomarker of SFN+CQ exposure/response. This study offers a novel combination regimen for future clinical investigations for prevention of prostate cancer in humans.

show abstract

“…OVM and members of the macroglobulin family have also been found to be involved in cancer pathological processes, and have been considered as potential biomarkers of cancer . It has been found that OVM expression was much higher than in normal ovaries during hen endometrioid adenocarcinoma .…”

Section: Introductionmentioning

confidence: 99%

Hen egg white ovomacroglobulin promotes fibroblast migration via mediating cell adhesion and cytoskeleton

Geng

Huang

2015

J Sci Food Agric

View full text Add to dashboard Cite

show abstract

Levels of acute inflammatory biomarkers in advanced prostate cancer patients with α2-macroglobulin deficiency

Cited by 7 publications

References 19 publications

Clinicopathological characteristics of androgen-dependent advanced prostate cancer patients with α2-macroglobulin deficiency

Clinicopathological characteristics of androgen-dependent advanced prostate cancer patients with α2-macroglobulin deficiency

Chemoprevention of Prostate Cancer by d,l-Sulforaphane Is Augmented by Pharmacological Inhibition of Autophagy

Hen egg white ovomacroglobulin promotes fibroblast migration via mediating cell adhesion and cytoskeleton

Contact Info

Product

Resources

About