2013
DOI: 10.1371/journal.pone.0056734
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Levels of Aqueous Humor Trace Elements in Patients with Non-Exsudative Age-related Macular Degeneration: A Case-control Study

Abstract: Trace elements might play a role in the complex multifactorial pathogenesis of age-related macular degeneration (AMD). The aim of this study was to measure alterations of trace elements levels in aqueous humor of patients with non-exsudative (dry) AMD.For this pilot study, aqueous humor samples were collected from patients undergoing cataract surgery. 12 patients with dry AMD (age 77.9±6.62, female 8, male 4) and 11 patients without AMD (age 66.6±16.7, female 7, male 4) were included. Aqueous levels of cadmium… Show more

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Cited by 57 publications
(55 citation statements)
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“…Other heavy metals like cadmium and lead have also been linked to ocular neurodegeneration (Kazi et al, 2006) (Junemann et al, 2013). Lead was associated with cataract in men (Schaumberg et al, 2004) and low-tension glaucoma in women (Yuki et al, 2009).…”
Section: The Role Of Iron and Heavy Metals In Amdmentioning
confidence: 99%
“…Other heavy metals like cadmium and lead have also been linked to ocular neurodegeneration (Kazi et al, 2006) (Junemann et al, 2013). Lead was associated with cataract in men (Schaumberg et al, 2004) and low-tension glaucoma in women (Yuki et al, 2009).…”
Section: The Role Of Iron and Heavy Metals In Amdmentioning
confidence: 99%
“…Metals present in Cigarette are responsible for producing reactive oxygen species [79,80]. As metals have a long halflife deposition in tissues occur [61] the radicals produced can cause peroxidation of Lipids, biomolecules degradation and breakup of DNA strand [81]. Cumulative damage to mitochondria can occur due to oxidative damage which is important for providing energy and cell survival [82], these metals can directly bind to antioxidant enzymes like Glutathione & increases their inactivated form to get deposited in lens [83].…”
Section: Discussionmentioning
confidence: 99%
“…The induction of HO-1 expression is the consequence of transcriptional activation of the HO-1 gene by cadmium [35]. In this context, the concentration of aqueous humor cadmium in patients with AMD was reported to be about 1 lmol/L (1 lM) [16]. Importantly, there were no noticeable changes in the expression levels of b-catenin and b-actin proteins over the 24-h treatment with cadmium.…”
Section: Cadmium Decreases the Expression Level Of Mitf-m In Human Epmentioning
confidence: 99%
“…MITF isoform multiplicity has been evolved to enable RPE to maintain total MITF protein levels, most likely MITF-H. This may provide RPE survival advantage because they are at increased risk for cadmium toxicity due to cumulative lifetime exposure [15,16,21].…”
Section: Cadmium Does Not Decrease the Expression Levels Of Total Mitmentioning
confidence: 99%
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