Levels of Calcium, Corrected Calcium, Alkaline Phosphatase and Inorganic Phosphorus in Patients’ Serum with β-Thalassemia Major on Subcutaneous Deferoxamine

Saboor, Muhammad

doi:10.4172/2329-8790.1000130

Cited by 17 publications

(15 citation statements)

References 15 publications

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“…28 While Saboor et al, in his study found serum calcium levels to be significantly lower in the cohort. 29 Hypocalcaemia seems to be related to hypoparathyroidism, as repeated blood transfusion results in iron deposition in the parathyroid gland which affects its normal functioning. 30 In this study, number of blood transfusion had an influence on the level of serum calcium and PTH.…”

Section: Discussionmentioning

confidence: 99%

Biochemical Status of Beta-Thalassemia Major Patients in Erbil City

Surchi

Ali

2018

EDJ

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Background and objectives: β-thalassemia major patient is one of the hereditary hemolytic diseases, which can cause many hematological and biochemical changes in the affected patient. And these changes can happen even when the patient is treated adequately. The objective was to study biochemical changes in the level of serum hepcidin, osteocalcin, calcium, ferritin, iron, PTH and IL-6 in patients with β-thalassemia major and to compare it with control subjects. Patients and method: In this research 40 patients with beta thalassemia major, 20 Female and 20 Male (age ranged from 10 to 38 years), and 40 control subjects 20 Female and 20 Male (age ranged from 9 to 33 years) were studied. Measurement of serum hepcidin, osteocalcin, calcium, ferritin, iron, PTH and IL-6 were done by the researcher for both cases and control groups. Results: Serum Ferritin and Iron were higher significantly in all thalassemic patients (P< 0.001), this increment was proportional with increasing number of units of blood transfusion and aging. Mean serum Hepcidin, PTH, Osteocalcin and IL6 were significantly lower in thalassemic patients in contrast to the control subjects (P< 0.001). Reduction in S-PTH was proportional to increasing number of blood transfusion and aging. But there was no significant difference in the level of serum Calcium in the majority of patients, only 9 patients had low serum calcium. Conclusion: Our study demonstrates that in B-thalassemia major patients Serum Ferritin and Iron were increased proportionally with increasing age and number of units of blood transfusion. Mean serum PTH, osteocalcin, hepcidin, and IL-6 were reduced, but mean serum calcium was remained normal.

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Section: Discussionmentioning

confidence: 99%

Biochemical Status of Beta-Thalassemia Major Patients in Erbil City

Surchi

Ali

2018

EDJ

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“…However, this brought various nonsiderotic, hematological, biochemical, and systemic complications. A sequence of skeletal complications including osteopenia, osteoporosis, scoliosis, skeletal deformities, bone pain, nerve compression, and spontaneous pathological fractures is not infrequent in transfusion dependent thalassemics [ 3 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Parathormone is mainly responsible for the regulation of calcium homeostasis in body. Hypoparathyroidism can lead to hypocalcemia and osteoporosis [ 4 ]. Calcium is a very important mineral in human body playing a major role in skeletal mineralization [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…In thalassemic patients, bone disease is an important cause of morbidity. Various skeletal complications including osteopenia, osteoporosis, scoliosis, rickets, spinal deformities, nerve compression, and spontaneous fractures are regularly reported in transfusion dependent thalassemics [ 3 , 4 ]. Diverse factors that contribute to skeletal disease including medullary expansion, iron accumulation, abnormal calcium-phosphorus balance, high bone turnover, hormonal insufficiency, and lastly hypoxia may influence skeletal complications [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Biochemical Markers of Bone Turnover in Patients withβ-Thalassemia Major: A Single Center Study from Southern Pakistan

Sultan

Irfan

Ahmed

2016

Advances in Hematology

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Objectives. Skeletal complications in β-homozygous thalassemic patients are uncommon but often debilitating, even amongst children and adolescent patients with well maintained transfusion and chelation therapy. The aim is to evaluate the biochemical markers of bone turnover in regularly transfused thalassemic patients and its possible correlations with demographic data and hematological and biochemical markers. Methods. In this prospective cross-sectional study, 36 β-thalassemia major patients were enrolled from March 2012 to March 2014. All patients underwent complete blood counts, LFTs, serum ferritin, serum calcium, phosphorus, serum albumin, alkaline phosphatase, 25-OH vitamin D, and parathormone (PTH) levels. Results. There were 17 males and 19 females with mean age of 12.56 ± 5.9 years. Hypocalcemia and hypophosphatemia were seen in 66.6% and 19.4%, respectively, while 25-OH vitamin D deficiency was present in 72.2% of thalassemic children and adolescents. Hypoparathyroidism was seen in 13.8% while hyperparathyroidism was detected in 8.3% of patients. There was direct correlation between serum phosphorus and ferritin levels (P < 0.05). No correlation was found between indirect bilirubin and skeletal parameters, calcium and parathyroid hormone (P > 0.05). Conclusions. Biochemical profile is significantly altered in patients with β-thalassemia major and bone associated biochemical abnormalities like hypocalcaemia, 25-OH vitamin D deficiency, and hypophosphatemia are not uncommon in Pakistani patients with thalassemia major.

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“…characterized by complete absence or reduced synthesis of alpha or beta globin chains leading to ineffective erythropoiesis and anemia. It is an autosomal disorder in which point mutation or deletion occur in the alpha or beta globin gene on chromosome 16(alpha) and 11(beta) [4][5][6] . A World Health Organization (WHO) data shows that about 3% population are carrier of beta thalassemia and about 4% population are carrier of Hb-E in Bangladesh.…”

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confidence: 99%

Evaluation of parathyroid function in adult male patients with transfusion dependent thalassemia

Urmi

Begum

Munira

2020

J Bangladesh Soc Physiol

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Background: In transfusion dependent thalassemic (TDT) patients regular blood transfusion leads to iron overload. This increased iron is deposited in the tissue of various system and causes organ damage. Endocrine dysfunction is very common due to iron deposition into the endocrine glands including parathyroid dysfunction. Objective: To measure plasma intact parathyroid hormone(iPTH), serum total calcium and inorganic phosphate levels in adult male patients with TDT. Methods:This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Dhaka from March 2018 to February 2019. Total 35 TDT male patients aged 18 to 40 year and 35 age matched apparently healthy male subjects were enrolled for this study as control. The TDT patients were selected from the outpatient department of Hematology and Transfusion Medicine. For assessment of parathyroid function serum albumin, plasma iPTH, serum total calcium and inorganic phosphate levels were estimated by colorimetric method using automated analyzer. For statistical analysis, independent sample t test was done. Results: In this study, plasma iPTH and serum corrected calcium levels were significantly (p < 0.001) lower in patients with TDT than those of healthy control. Again, Serum inorganic phosphate and ALP levels were significantly (p < 0.001) higher in patients with TDT than those of healthy control. Moreover, 2.86% of TDT patients had low iPTH. Conclusion: From this study, it can be concluded that reduced parathyroid function was associated with TDT. J Bangladesh Soc Physiol. 2019, December; 14(2): 77-81

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Levels of Calcium, Corrected Calcium, Alkaline Phosphatase and Inorganic Phosphorus in Patients’ Serum with β-Thalassemia Major on Subcutaneous Deferoxamine

Cited by 17 publications

References 15 publications

Biochemical Status of Beta-Thalassemia Major Patients in Erbil City

Biochemical Status of Beta-Thalassemia Major Patients in Erbil City

Biochemical Markers of Bone Turnover in Patients withβ-Thalassemia Major: A Single Center Study from Southern Pakistan

Evaluation of parathyroid function in adult male patients with transfusion dependent thalassemia

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