Levels of calprotectin (leukocyte L1 protein) during apheresis

Hetland, Geir; Berntzen, H. B.; Fagerhol, Magne K.

doi:10.3109/00365519209090124

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…The 27E10 antigen is known to be upregulated by interferon-γ (Zwadlo et al, 1986), and interferon-γ-secreting inflammatory T cells may induce this phenotype in Guillain-Barré syndrome and CIDP nerves. It has also been shown that the soluble form of the 27E10 antigen is increased in the serum of Guillain-Barré syndrome patients prior to plasma exchange (Hetland et al, 1992). Changes in extracellular matrix composition may also account for phenotype differentiation (Mahnke et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Macrophage differentiation antigens in acute and chronic autoimmune polyneuropathies [published erratum appears in Brain 1998 Jun;121(Pt 6):1190]

Kiefer

Kieseier²,

Brück³

et al. 1998

Brain

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The pathological differential diagnosis between potentially treatable autoimmune neuropathies and degenerative neuropathies is often difficult if major T-cell infiltrates are absent in sural nerve biopsies. Since it is suggested that macrophages play a central pathogenetic role in inflammatory neuropathies, we investigated the expression of macrophage differentiation antigens associated with acute (MRP14 and 27E10 antigens) and more chronic inflammation (MRP8 and 25F9 antigens) in 76 sural nerve biopsies from patients with Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, other inflammatory neuropathies, hereditary neuropathies and normal sural nerves. Macrophage differentiation antigens were immunocytochemically detected in a majority of inflammatory biopsies but rarely in non-inflammatory disease controls and normal-looking nerves. Quantification of labelled endoneurial cells revealed significantly elevated cell counts compared with controls. In individual biopsies, elevated levels of one differentiation antigen were not necessarily associated with high expression of the other antigens, pointing to functional heterogeneity of endoneurial macrophages. Endoneurial cell counts for at least one of the differentiation markers that were greater than in any of the non-inflammatory control nerves were found in two-thirds of all inflammatory biopsies, whereas T-cell counts and in particular total macrophage counts were less sensitive in picking up biopsies from patients with inflammatory neuropathies. Antibodies to macrophage differentiation antigens are additional simple and helpful diagnostic tools in differentiating autoimmune from non-inflammatory neuropathies in sural nerve biopsies.

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Section: Discussionmentioning

confidence: 99%

Macrophage differentiation antigens in acute and chronic autoimmune polyneuropathies [published erratum appears in Brain 1998 Jun;121(Pt 6):1190]

Kiefer

Kieseier²,

Brück³

et al. 1998

Brain

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show abstract

“…15 Stimulation of PMN with these ligands triggers a range of biological activities including chemotaxis, superoxide formation, enzyme release, and aggregation. [16][17][18][19] Previously, we found that the plasma concentration of calprotectin increased after plasma apheresis in patients with Waldenström's syndrome, 20 and suspected that this was related to the increase in complement activation products seen in one of these patients. 21 Recently, Garred et al showed that the release of calprotectin coincided with activation of complement during major surgery.…”

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confidence: 99%