2023
DOI: 10.3390/cells12242774
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Levels of Cell-Free DNA in Kidney Failure Patients before and after Renal Transplantation

Chiara Leotta,
Leah Hernandez,
Lubomira Tothova
et al.

Abstract: Circulating cell-free DNA (cfDNA) has diverse applications in oncological, prenatal, toxicological, cardiovascular, and autoimmune diseases, diagnostics, and organ transplantation. In particular, mitochondrial cfDNA (mt-cfDNA) is associated with inflammation and linked to early vascular ageing (EVA) in end-stage kidney failure (ESKF), which could be a noninvasive marker for graft rejection and organ damage. Plasma samples from 44 ESKF patients, of whom half (n = 22) underwent either conservative therapy (non-H… Show more

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