Levels of Circulating miR-133a Are Elevated in Sepsis and Predict Mortality in Critically Ill Patients

Tacke, Frank; Roderburg, Christoph; Benz, Fabian; Cardenas, David Vargas; Luedde, Mark; Hippe, Hans-Joerg; Frey, Norbert; Vucur, Mihael; Gautheron, Jérémie; Koch, Alexander; Trautwein, Christian; Luedde, Tom

doi:10.1097/ccm.0000000000000131

Cited by 112 publications

(118 citation statements)

References 27 publications

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“…In patients in shock related to sepsis and organ failure, significant correlations between miR-133a and disease severity have been revealed; patients with an APACHE-II score above 10 had significantly higher miR-133a levels than those with an APACHE-II below 10 [54]. The study by Tacke et al illustrates that specific miRNAs can be used as predictors for an unfavorable prognosis, and for both short-and long-term mortality in critically ill patients.…”

Section: Discussionmentioning

confidence: 92%

Serum levels of unique miR-551-5p and endothelial-specific miR-126a-5p allow discrimination of patients in the early phase of acute pancreatitis

et al. 2015

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Section: Discussionmentioning

confidence: 92%

Serum levels of unique miR-551-5p and endothelial-specific miR-126a-5p allow discrimination of patients in the early phase of acute pancreatitis

et al. 2015

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“…Roderburg et al, investigated the microRNAs expression in patients with sepsis, reporting an increase in microRNA-150 expression (Roderburg et al 2013). Tacke et al, underwent a similar study which proved a rise in microRNA-133a expression (Tacke et al 2014). Sun et al, documented the modifications seen in microRNAs expression in patients suffering from sepsis, along with which he noted a significant fall in microRNA-181b concentration (Sun et al 2012).…”

Section: The Micrornas Expression In Sepsis and Its Implications In Nmentioning

confidence: 94%

The Expression of Nuclear Transcription Factor Kappa B (NF-κB) in the Case of Critically Ill Polytrauma Patients with Sepsis and Its Interactions with microRNAs

Păpurică¹,

Rogobete²,

Săndesc³

et al. 2016

Biochem Genet

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Critical polytrauma patients present a series of pathophysiological disturbances, biochemical and molecular dysfunction, which comprise to be the major cause of intensive care unit admission. In regard to molecular damage, there exists a series of factors, which all together contribute to the aggravation of the clinical status leading to increased mortality rate in these patients. One of the most important biochemical factors involved is the nuclear transcription factor B (NF-κB). Impaired NF-κB functioning is reflected on the clinical status of the patient through increased production of pro-inflammatory molecule, leading to multiple organ dysfunction syndrome. In addition to this, through microRNAs interactions, various pathophysiological as well as biochemical disturbances are produced, which altogether further reduce the patient's survival rate. In this paper, we would like to present the modifications seen in the expression of NF-κB in critically polytraumatized patients with sepsis. In additions to this, we would like to discuss the correlation between the microRNAs and its further implications in clinical status of these patients.

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“…MicroRNAs (miRNAs) are a class of gene products that are implicated in several lung diseases [23][24][25] and have emerged as novel biomarkers 26 and possible therapeutic strategies. 27 Recent studies revealed that miR-21 was dynamically regulated in LPS-induced ALI.…”

mentioning

confidence: 99%

Lipoxin A4 activates alveolar epithelial sodium channel gamma via the microRNA-21/PTEN/AKT pathway in lipopolysaccharide-induced inflammatory lung injury

Cai

et al. 2015

Laboratory Investigation

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Lipoxin A 4 (LXA 4 ), as an endogenously produced lipid mediator, promotes the resolution of inflammation. Previously, we demonstrated that LXA 4 stimulated alveolar fluid clearance through alveolar epithelial sodium channel gamma (ENaC-γ). In this study, we sought to investigate the mechanisms of LXA 4 in modulation of ENaC-γ in lipopolysaccharide (LPS)-induced inflammatory lung injury. miR-21 was upregulated during an LPS challenge and downregulated by LXA 4 administration in vivo and in vitro. Serum miR-21 concentration was also elevated in acute respiratory distress syndrome patients as compared with healthy volunteers. LPS increased miR-21 expression by activation of activator protein 1 (AP-1). In A549 cells, miR-21 upregulated phosphorylation of AKT activation via inhibition of phosphatase and tensin homolog (PTEN), and therefore reduced the expression of ENaC-γ. In contrast, LXA 4 reversed LPS-inhibited ENaC-γ expression through inhibition of AP-1 and activation of PTEN. In addition, an miR-21 inhibitor mimicked the effects of LXA 4 ; overexpression of miR-21 abolished the protective effects of LXA 4 . Finally, both AKT and ERK inhibitors (LY294002 and UO126) blocked effects of LPS on the depression of ENaC-γ. However, LXA 4 only inhibited LPS-induced phosphorylation of AKT. In summary, LXA 4 activates ENaC-γ in part via the miR-21/PTEN/AKT signaling pathway.

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Levels of Circulating miR-133a Are Elevated in Sepsis and Predict Mortality in Critically Ill Patients

Abstract: miR-133a serum levels were significantly elevated in critical illness and sepsis. High miR-133a levels were associated with the severity of disease and predicted an unfavorable outcome of critically ill patients.

Cited by 112 publications

References 27 publications

Serum levels of unique miR-551-5p and endothelial-specific miR-126a-5p allow discrimination of patients in the early phase of acute pancreatitis

Serum levels of unique miR-551-5p and endothelial-specific miR-126a-5p allow discrimination of patients in the early phase of acute pancreatitis

The Expression of Nuclear Transcription Factor Kappa B (NF-κB) in the Case of Critically Ill Polytrauma Patients with Sepsis and Its Interactions with microRNAs

Lipoxin A4 activates alveolar epithelial sodium channel gamma via the microRNA-21/PTEN/AKT pathway in lipopolysaccharide-induced inflammatory lung injury

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