Levels of colostral antibodies against neonatal calf diaahoea virus

Woode, G. N.; Jones, Julia A.; Bridger, Janice C.

doi:10.1136/vr.97.8.148

Cited by 100 publications

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“…The causes might be the following. Colostrum and milk antibodies are more important than serum antibodies, because of their painting effect in the gut for protection from infection [5,[12][13][14]21]. In this trial, milk antibody titers to BRV decreased immediately after 2 days of calving, and those were below the levels to be protective against natural BRV infections when that milk was fed to naturally suckled calves.…”

mentioning

confidence: 99%

Enhancement of Passive Immunity with Maternal Vaccine against Newborn Calf Diarrhea.

Kohara

Hirai

Mori

et al. 1997

The Journal of Veterinary Medical Science

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ABSTRACT. The effects of a maternal vaccine against newborn calf diarrhea associated with group A bovine rotavirus (BRV), bovine coronavirus (BCV), bovine parvovirus and K99 Escherichia coli (E.coli) were examined on a beef cow-calf herd. After vaccination, serum or colostrum antibody titers to BRV, BCV and E. coli K99 in the vaccinated cows were significantly higher than those in unvaccinated control cows. Serum antibody titers to BRV, BCV and E. coli K99 in calves from the vaccinated cows were also significantly higher than those in calves from the control cows for 3-4 weeks after birth. These results suggested that the immunization of cows with the maternal vaccine enhanced the passive immunity levels in calves against BRV, BCV and K99 E. coli. -KEY WORDS: bovine coronavirus, bovine rotavirus, K99 Escherichia coli.J. Vet. Med. Sci. 59(11): 1023-1025, 1997 the first vaccination, the second booster injection was given in the same manner. The remaining 48 cows served as unvaccinated controls. The calves from the vaccinated and control cows were observed for clinical signs once daily. Serum samples were collected from the vaccinated cows at vaccination, at calving and post-calving days 2, 7 and 28, and from the control cows at times corresponding to sampling in the vaccinated cows. Colostrum and milk samples were collected from all the cows on the day of calving and post-calving days 2, 7 and 28. Serum and feces were taken from all the calves on days 2, 7, 21 and 28 after birth. Feces were also obtained when these calves developed diarrhea. The fecal suspensions were examined for enteric viruses by electron microscopy [2], and group A BRV was also detected by a latex agglutination test (Rotalex; Orion Diagnosis, Espoo, Finland). Virus-neutralizing antibody titers to NCDV (G6) and KK3 (G10) strains of group A BRV in serum and milk samples were determined by a fluorescence focus neutralizing (FFN) test with MA104 cells as described previously [9]. The virus-neutralizing antibody titers to the Mebus strain of BCV and the BF-15 strain of BPV were determined by CPE inhibition tests with HRT-18 cells and BT cells, respectively [15,19]. E. coli K99 antibody titers were determined by a passive hemagglutination test [8]. Statistical analysis of the data was performed using the Student's t-test and the χ 2 test.Abortions and other adverse reactions were not observed in the 48 vaccinated pregnant cows. At the first vaccination, there were no differences in serum antibody titers to BRV, BCV, BPV and E. coli K99 between the vaccinated and control cows. At the second vaccination, serum antibody titers to both G serotypes of BRV, BCV and E. coli K99 in the vaccinated cows increased and were higher than those of controls (P<0.05) ( Table 1). Colostrum antibody titers to both serotypes of BRV and E. coli K99 in the vaccinated cows were higher than those of control cows (P<0.05). For 3-4 weeks after birth, the calves from the vaccinated cows

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confidence: 99%

Enhancement of Passive Immunity with Maternal Vaccine against Newborn Calf Diarrhea.

Kohara

Hirai

Mori

et al. 1997

The Journal of Veterinary Medical Science

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“…The evidence published in the past few years suggests that passive local immunity of the small intestine in the young as mediated through colostrum and milk antibodies of immune dams is of value not only in TGE, but also in other gastroenteric viral infections such as rotavirus infections of piglets (Lecce et al 1976) and lambs (Snodgrass and Wells 1976) and rotavirus and coronavirus infections of .calves (Mebus et al 1973;Woode et al 1975). As in TGE, the infectious process of these gastroenteric viral diseases remains localized to the intestinal tract and can be affected only by antibodies present directly in the intestine.…”

Section: Discussionmentioning

confidence: 99%

Preparation of Hyperimmune Cow Colostrum Whey and its Use in the Protection of Piglets against Transmissible Gastroenteritis

Štěpánek¹,

J²,

Fränz³

et al. 1982

Acta Vet. Brno

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Stepanek J., J. MenSik, J. Franz, J. Krejci: Preparation of Hyperimmune Cow Colostrum Whey and its Use in the Protection of Piglets against Transmissible Gastroenteritis. Acta vet. Bmo, 51, 1982: 99 -108. Parenteral administration of porcine transmissible gastroenteritis (TGE) virus topregnant cows resulted in the production of virus-neutralising antibodies which peaked 4 to 5 weeks after the start of immunization. Blood serum antibody titres were higher in cows immunized intravenously or subcutaneously than in those immunized into the mammary gland. Antibody concentration in the colostrum collected within 6 hours of parturition was little affected by the mode of antigen administration. In subsequent colostrum and milk samples, however, antibody titres of the cows immunized' into the mammary gland were higher up to the 6th day after parturition. Regular oral administration of whey prepared from the colostrum of immunized cows had a favourable effect on the course of transmissible gastroenteritis in experimentally infected piglets and considerably reduced their mortality. As compared to controls, the treated animals had the incubation time prolonged by at least 24 hours and showed less intense clinical signs which, in sow-reared piglets, were limited to sporadic vomiting.

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“…Ancak her ne kadar sığır populasyonunda BRV ve BCV enfeksiyonları oldukça yaygın ise de; 'doğal enfekte sı-ğırlarda antikor titrelerinin genellikle çok yüksek dü-zeyde olmadığı ve bu nedenle bağışık annelerin yeni doğan buzağıları muhtemelen ilk birkaç günden sonra enfeksiyona karşı koruyamadıkları bilinmektedir (21,22,23). Nitekim bu çalışmada gerek araştırmada kullanılan sığırlardan (41 adet) ilk aşılama zamanında sağlanan, gerekse Grup lI'de bulunan aşı uygulanmamış sığırlardan doğum zamanında alınan kan örneklerinde belirlenen doğal enfeksiyona ilgili BRV ve BCV için seropozitiflik oranları ve antikor titreleri de (Tablo 3) benzer verileri ortaya koymuştur.…”

Section: Bulgularunclassified

Yeni doğan buzağı ishallerine karşı ticari aşı ile aşılanan sığırlardan doğan yavrularda pasif bağışıklık düzeyi

Alkan¹,

Burgu²,

Can-Şahna³

et al. 2004

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Özet: Bu çalışmada, bir ticari aşı (ScourGuard@(K),Pfizer) ile aşılanan sıgırlarda BRV ve BCV spesifik bagışıklıgın düzeyi ile yeni doganIarın enfeksiyonunda pasif bagışıklıgın rolü incelendi. Bu amaçla gebeliginin 3. trimesterinde bulunan 41 sıgırdan 2 grup oluşturuldu. Grup I'de bulunan sıgırlara ticari aşı prospektüsüne göre aşı uygulandı. Grup II ise kontrol grubu olarak degerlendirildi. Her iki gruptaki sıgırlardan aşı uygulamalanna paralel, dogum yaptıkları gün (L.gün) ve sonraki 3, 7, 14, 21 ve 28. günlerde kan, gaita ve kolostrum/süt (aşı uygulama dönemleri hariç) örnekleri; yeni dogan buzagılardan dogum sonrası 3, 7, 14,21,28. günlerde kan ve gaita örnekleri alındı. Kan ve kolostrumlsüt örnekleri BRV ve BCV spesifik antikorlar yönünden mikronötralizasyon, gaita örnekleri BRV ve BCV antijeni yönünden ELlSA ile kontrol edildi. Elde edilen verilere göre, aşı uygulanan ve aşı uygulanmayan sıgırlara ait kan serumu ve kolostrum/süt örneklerindeki antikor seviyeleri ile yeni dogan buzagıların pasif bagışıklık düzeyi ve enfeksiyona maruz kalma oranları karşılaştırmalı olarak degerlendirildi. Aşı uygulamasını takiben erişkin sıgırlarda aşı etkenlerine spesifik antikor yanıtında belirgin bir artış saptanamadı. Ancak aşı uygulanan ve aşı uygulanmayan annelerden dogan buzagılarda enfeksiyona maruz kalma oranlannın sırasıyla %30.0 ve %54.5 oldugu belirlendi.Anahtar kelimeler: AŞı, coronavirus, maternal bagışıklık, rotavirus, Si gır.Level of the passiye immunity in calves from cows vaccinated for neonatal calf diarrhea Summary: In this study, the level of the BRV and BCV specific immunity in cows which vaccinated with a commercial vaccine (ScourGuard@(K),pfizer) and the role of the passiye immunity in newborns' infections were investigated. For this aim two groups were organised from 4 i cows in their 3 rd trimaster of pregnancy. Group I cows were vaccinated according to the prosedure of the commercial vaccine. Group II cows were used as a control. At the time of the vaccination, at the calving day (l st day) and at 3,7,14,21 and 28 th day s after calving, blood, feces and colostrumlmilk (except vaccination period) samples from cows in each group; from newbom calves at 3,7,14,21,28 lh days after birth blood and feces samples were collected. Blood and colostrumlmilk samples were controlled for the presence of BRV and BCV antibodies using microneutralisation technique. Feces were tested for BRV and BCV antigen by ELlSA. The antibody titers in blood sera and colostrumlmilk from cows, levels of the passiye immunity of newbom calves and the infection rates of calves were evaluated comparatively for Group I and II cows, their calves. Data show n that following the vaccination no remarkable specific antibody increase against vaccine antigens (BRV and BCV) was detected in cows. However the infection rate of calves bom from vaccinated and unvaccinated cows were 30.0% and 54.5%, respectively.Key words: Cattle, coronavirus, maternal immunity, rotavirus, vaccine. GirişYeni doğan buzağı ishallerinde cryptosporidium, en-

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Levels of colostral antibodies against neonatal calf diaahoea virus

Cited by 100 publications

References 0 publications

Enhancement of Passive Immunity with Maternal Vaccine against Newborn Calf Diarrhea.

Enhancement of Passive Immunity with Maternal Vaccine against Newborn Calf Diarrhea.

Preparation of Hyperimmune Cow Colostrum Whey and its Use in the Protection of Piglets against Transmissible Gastroenteritis

Yeni doğan buzağı ishallerine karşı ticari aşı ile aşılanan sığırlardan doğan yavrularda pasif bağışıklık düzeyi

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