Levels of Expression of P-Selectin, E-Selectin, and Intercellular Adhesion Molecule-1 in Coronary Atherectomy Specimens from Patients With Stable and Unstable Angina Pectoris

Expression of Cytokine and Adhesion Molecule mRNA in Atherectomy Specimens From Patients With Coronary Artery Disease

“…However, Tenaglia et al reported no significant difference in the levels of ICAM-1 or Eselectin, as determined by immunohistochemistry, between UAP and SAP, with no increase in the levels of IL-1 in DCA specimens from UAP patients compared with those of SAP. 25 The IL-1 in plaques may be responsible for the levels of ICAM-1 and E-selectin because IL-1 has been shown to enhance the levels of these adhesion molecules. 26,27 The difference in the levels of ICAM-1 and Eselectin between the 2 laboratories may be due to the levels of IL-1 .…”

Incorporating biomarkers into clinical trials in cardiovascular medicine

“…60 In addition, patients with unstable angina exhibit significantly higher levels of P-selectin expression in coronary atherectomy specimens than patients with stable angina. 61,62 Elevated levels of sP-selectin were also observed in patients with vascular disorders such as hypertension and hypercholesterolemia. 36,37 In patients with acute cerebral infarction, P-selectin and sP-selectin levels have been shown to be elevated compared to healthy individuals, and to correlate with an increase in phospholipase A 2 (PLA).…”

Biomarkers of Atherosclerosis and Acute Coronary Syndromes - A Clinical Perspective

“…It is expressed by endothelial cells in atherosclerotic, but not normal, vessels (73,74), with expression being particularly marked in patients with unstable angina (75). Pselectin is also expressed by activated platelets and has been used as a marker of platelet activation (76).…”