Levels of Fructose-2,6-Bisphosphate in Lymphocytes of Diabetic Patients.

Abstract

Background: Patients with diabetes mellitus have infections more often than those without diabetes. Severalfactors predispose diabetic patients to infections, including an alteration in immune defense mechanism. Elevated levels of fructose-2,6- bisphosphate in lymphocyte have been shown in diabetic patients. The activation ofglycolysis by fructose -2,6- bisphosphate in peripheral blood mononuclear cells causes the accumulation of glycolytic metabolites and inhibits the activation of immune cells.Objective: To observe and compare the levels of fructose-2,6-bisphosphate in lymphocytes of diabetics and normal subjectsMaterial and Methods: 200 diabetic and 50 control subjects were selected for study .The subjects were evaluated for severity of diabetes and their fasting blood glucose, HbA1C, total leucocyte count, lymphocyte count andfructose-2,6-bisphosphate in lymphocytes were estimated.Results: The results show that mean fasting blood glucose, HbA1C, total leucocytes count and fructose-2,6-bisphosphate levels in lymphocytes were significantly higher (P<0.001) while lymphocyte count was significantlylower (P<0.001) in diabetic patients as compared to control group.Conclusions: It was concluded from the facts observed in this study that elevated levels of fructose-2,6-bisphosphate in lymphocytes and decreased number of lymphocytes may have induced chances of infections indiabetic patients.Keywords: Lymphocytes, Fructose-2,6-bisphosphate, Diabetes, Infections.