Levels of interleukin-33 and interleukin-6 in patients with acute coronary syndrome or stable angina

Liu, Cong-Lin; Shen, Deliang; Kui, Zhu; Tang, Junnan; Hai, Qimin; Zhang, Jinying

doi:10.25011/cim.v36i4.19957

Cited by 14 publications

(9 citation statements)

References 28 publications

(30 reference statements)

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“…20 This finding is in accordance with that of Liu et al who too had reported higher serum levels of IL-6 in patients with multivessel disease as compared with control group. 24 In our study, we observed a significant correlation with IL-6 levels and mGS, a finding reported by Tanidi et al 25 However, Mohktar et al found no association between IL-6 levels and the Gensini score. 20…”

Section: Discussionsupporting

confidence: 74%

High-sensitivity C-reactive protein and interleukin-6 as risk predictors in patients with stable angina pectoris

et al. 2020

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Background: Cardiovascular diseases are a leading cause of morbidity and mortality especially in developing countries such as India. Biomarkers such as high-sensitivity C-reactive protein (Hs-CRP) and interleukin-6 (IL-6) can help in risk stratification and better management of patients with stable angina.Methods: This was a prospective observational study wherein symptomatic patients with stable angina were enrolled. Coronary angiogram was done in those consenting to the procedure. Severity of coronary stenosis was graded as per the modified Gensini score (mGS). Hs-CRP and IL-6 levels were determined pre-procedure and 24 hours post percutaneous coronary intervention (PCI). Based on angiographic profile, patients were subdivided into four groups: group 1: normal coronaries, group 2: single vessel disease, group 3: double vessel disease and group 4: triple vessel disease. Primary outcome was occurrence of major adverse cardiovascular events over one-year period.Results: A total of 158 patients completed the study with a mean age of 62.8±9.6 years. A significant difference was observed between the four groups in terms of age, Hs-CRP and IL-6 levels. Of the 124 patients undergoing PCI, significant difference was observed in terms of pre and post procedure Hs-CRP (P<0.0001) and IL-6 levels (P<0.0001). Strong positive correlation was seen between Hs-CRP and IL-6 levels with modified Gensini scoring (mGS). Patients with MACE (15/158; 9.4%) had significantly higher levels of Hs-CRP and IL-6. Multivariate logistic regression analysis revealed that Hs-CRP, IL-6, ΔHs-CRP and ΔIL-6 were independent predictors of major adverse cardiovascular events (MACE).Conclusions: Hs-CRP and IL-6 levels were independent predictors of outcomes and can be used for risk stratification in these patients..

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Section: Discussionsupporting

confidence: 74%

High-sensitivity C-reactive protein and interleukin-6 as risk predictors in patients with stable angina pectoris

et al. 2020

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“…It is also influential in the protection of cardiac muscle. In recent years, it has been the subject of much research that IL-33 and ST2 are associated with acute myocardial infarction, acute and chronic heart failure, aortic stenosis, and diastolic dysfunction, and interestingly, increased ST2 levels were generally found to be associated with poor outcomes [51–53]. Moreover, it has been suggested that ST2 levels can be used as a cardiac biomarker [54].…”

Section: Discussionmentioning

confidence: 99%

IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival

et al. 2017

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ObjectiveIncreased inflammation, associated with the increase in chronic kidney disease (CKD) stage, has a very important influence in vascular injury and cardiovascular diseases. In this study, we aimed to investigate the levels of IL-33 and ST2 in the different stages of CKD and to determine their effect on vascular damage and cardiovascular events (CVE).MethodsThis was an observational cohort study in which serum IL-33 and ST2 were obtained from 238 CKD (stages 1–5) patients. We examined the changes in IL-33/ST2 levels in CKD patients, as well as the association with a surrogate of endothelial dysfunction. Fatal and non-fatal CVE were recorded for a mean of 24 months. We also performed a COX regression analysis to determine the association of IL-33/ST2 levels with CVE and survival.ResultsIL-33 and ST2 levels were significantly increased and estimated glomerular filtration rates (eGFR) were decreased. Flow-mediated dilatation (FMD) was significantly decreased from stage 1 to stage 5 CKD. IL-33 and ST2 levels were associated with FMD, and ST2 was a predictor. Multivariate Cox analysis showed that the presence of diabetes mellitus, smoking, and proteinuria and haemoglobin, Hs-CRP, IL-33, and ST2 were associated with the risk of CVE. Kaplan-Meier survival curves showed that patients with IL-33 and ST2 levels below the median value (IL-33 = 132.6 ng/L, ST2 = 382.9 pg/mL) had a higher cumulative survival compared with patients who had IL-33 and ST2 levels above the median value (log-rank test, p = 0.000).ConclusionThis is the first study that demonstrates that serum IL-33 and ST2 are associated with vascular injury, cardiovascular events, and survival in CKD patients.

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“…Human studies have demonstrated that the circulating levels of IL-33 and sST2 are associated with the severity of ACS patients, and may thus serve as potential biomarkers. The serum level of IL-33 is significantly lower in patients with ACS compared with stable angina pectoris patients and control individuals (31, 32). Similarly, another study showed that the circulating level of IL-33 is significantly lower in ACS patients than in patients with coronary artery disease (33).…”

Section: Cytokinesmentioning

confidence: 96%

Regulation of Type 2 Immunity in Myocardial Infarction

Xiong

et al. 2019

Front. Immunol.

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Type 2 immunity participates in the pathogeneses of helminth infection and allergic diseases. Emerging evidence indicates that the components of type 2 immunity are also involved in maintaining metabolic hemostasis and facilitating the healing process after tissue injury. Numerous preclinical studies have suggested regulation of type 2 immunity-related cytokines, such as interleukin-4, -13, and -33, and cell types, such as M2 macrophages, mast cells, and eosinophils, affects cardiac functions after myocardial infarction (MI), providing new insights into the importance of immune modulation in the infarcted heart. This review provides an overview of the functions of these cytokines and cells in the setting of MI as well as their potential to predict the severity and prognosis of MI.

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Levels of interleukin-33 and interleukin-6 in patients with acute coronary syndrome or stable angina

Cited by 14 publications

References 28 publications

High-sensitivity C-reactive protein and interleukin-6 as risk predictors in patients with stable angina pectoris

High-sensitivity C-reactive protein and interleukin-6 as risk predictors in patients with stable angina pectoris

IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival

Regulation of Type 2 Immunity in Myocardial Infarction

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