Levels of interleukins 2, 6, 8, and 10 in patients with irritable bowel syndrome

Abstract

Irritable bowel syndrome (IBS) was previously considered as a psychosomatic disorder. But recent studies indicate that inflammation plays a significant role. The present study was undertaken to evaluate role of pro-inflammatory (IL 2, IL 6 and IL 8) and anti-inflammatory (IL 10) cytokines in clinically diagnosed patients of IBS. 51 patients and 29 controls were included in this study. On the basis of history of gastrointestinal infection, patients were divided into Post Infectious (PIIBS) and Non Post Infectious (NPIIBS) groups. All subsequently underwent colonoscopy and a rectosigmoid biopsy as well as measurement of levels of IL 2, 6, 8 and 10. The levels of IL 2 and IL 8 were significantly raised in IBS patients compared to controls with the mean level of IL 2,6 and 8 higher in PIIBS group than NPIIBS group but statistically significant for IL 8 only. The mean level IL-10 was reduced in patients compared to controls but statistically insignificant. Present study shows that Interleukin levels are altered in patients suffering from IBS and may have a key role in its pathogenesis.

Somatization in patients with predominant diarrhoea irritable bowel syndrome: the role of the intestinal barrier function and integrity

“…In previous work by our group [ 47 ], higher plasma levels of IL-6, IL-8, resistin, and adiponectin were shown in IBS-D patients compared to controls, supporting the hypothesis of an inflammatory component in this functional GI disorder. Conversely, in the present paper, IBS-D patients with high somatization showed a significant increase in IL-8 and a parallel decrease in IL-10 concentrations [ 48 ]. IL-8 and the related cytokines are reported to be high in several tissues in the case of different pathological conditions (e.g., infection, inflammation, ischemia, trauma) and are thought to be able to induce a local neutrophil accumulation [ 49 ].…”

Clinical Response and Changes of Cytokines and Zonulin Levels in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Treated with Bifidobacterium Longum ES1 for 8 or 12 Weeks: A Preliminary Report

“…Consistently, we found a significant positive correlation between abdominal pain intensity and TNFα levels. Several studies have reported an imbalance in pro-inflammatory cytokines, such as IL-6, IL-8 and TNFα, in patients with IBS compared to controls [ 46 , 47 , 48 , 49 ]. Unfortunately, in the present study, we were not able to substantiate this data due to the lack of a healthy control population.…”

Relación del estrés oxidante con marcadores de inflamación en síndrome de intestino irritable

“…Sin embargo, esto aún no está completamente establecido ya que existe una diferencia de opinión con respecto al perfil de interleucinas en SII. Patel et al, 2017, midieron los niveles de IL-2, 6, 8 y 10 en pacientes con SII y reportaron que los niveles de IL-2 e IL-8 estaban en mayor concentración en los pacientes con SII en comparación con los controles. Hughes et al, 2013, mostraron que los niveles sanguíneos de IL-1β, TNF-α e IL-6 se correlacionan positivamente con los síntomas del SII, mientras que se han observado correlaciones negativas para IL-10 e IL-12.…”