Levels of nasal nitric oxide and nitric oxide synthase expression in chronic rhinosinusitis with nasal polyposis

Abstract

KEY POINTSCRSwNP patients had decreased nNO and increased SNOT‐22, endoscopy, and CT scores.CRSwNP patients exhibited decreased nNO despite elevated iNOS and eNOS mRNA expression.The mechanism behind lowered nNO in CRSwNP may not be related to NOS expression.

Nasal nitric oxide and chronic rhinosinusitis with nasal polyps: Is it a matter of inflammation or mechanical obstruction?

“…We have read with keen interest the recent manuscript authored by Wu et al, 1 which was published in the July issue of the journal. In their intriguing study, the authors examined the correlation between nasal nitric oxide (nNO) levels and mRNA expression of the inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) isoforms in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) and controls.…”