Levels of nitric oxide, asymmetric dimethyl arginine, symmetric dimethyl arginine,and L-arginine in patients with obsessive-compulsive disorder

Yilmaz, Enver Demirel; Üstündağ, Mehmet; Gençer, Ali Görkem; Kıvrak, Yüksel; Ünal, Özge; Bilici, Mustafa

doi:10.3906/sag-1503-100

Cited by 10 publications

(7 citation statements)

References 57 publications

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“…From full‐text review of the resulting 31 papers, 14 did not meet inclusion criteria and 17 were included in our qualitative synthesis. Four of these were ineligible for quantitative synthesis, resulting in 13 studies considered for quantitative analysis . Two of these studies assessed the same sample, but data from both were included since they provided complementary information (i.e., distinct markers and correlation between TBARS and Y‐BOCS) .…”

Section: Resultsmentioning

confidence: 99%

“…Growing evidence supports the possibility that psychiatric disorders may be considered multisystem disorders, with patients presenting altered immune and oxidative markers, when compared to healthy controls . Specifically for OCD, while its exact etiology and pathophysiology remain unknown, systemic dysregulation of inflammation and oxidative stress has been increasingly reported . Regarding inflammation, recent meta‐analyses have confirmed that patients with OCD have reduced plasma IL‐1β and increased anti‐basal ganglia antibodies, in comparison with healthy controls .…”

Section: Introductionmentioning

confidence: 99%

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Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis

Maia

Oliveira

Lajnef

et al. 2019

Acta Psychiatr Scand

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Oxidative and nitrosative stress markers in obsessive-compulsive disorder: a systematic review and meta-analysis Maia A, Oliveira J, Lajnef M, Mallet L, Tamouza R, Leboyer M, Oliveira-Maia AJ. Oxidative and nitrosative stress markers in obsessive-compulsive disorder: a systematic review and meta-analysis Objective: Obsessive-compulsive disorder (OCD) is a chronic, prevalent, and highly impairing psychiatric illness. Although the pathophysiology of OCD remains unknown, pathways involved in oxidative and nitrosative stress (O&NS) have been implicated. The present study aims to systematically review the literature for quantitative evidence that patients with OCD have altered measures of blood O&NS markers. Methods: Independent random-effects meta-analyses using standardized mean differences were conducted to assess each marker separately. Additionally, data from multiple markers were pooled together in a metaanalysis for measures of oxidant activity and another for measures of antioxidant activity. Results: Thirteen studies met inclusion criteria, involving 433 OCD patients and 459 controls. Eleven blood O&NS markers were eligible for independent quantitative analyses. We found that, in OCD patients, the oxidant markers 8-hydroxydeoxyguanosine and malondialdehyde, and the antioxidants glutathione peroxidase and superoxide dismutase, were significantly increased while total antioxidant status, vitamin C, and vitamin E were significantly decreased, when comparing with controls. Regarding pooled meta-analyses, we found a statistically significant increase in oxidant markers, but non-significant results regarding antioxidant markers. Conclusions: Our meta-analysis suggests that OCD patients have a systemic oxidative imbalance that is not adequately buffered by the antioxidant system. Additional studies are needed in order to support this association. Summations• Patients with obsessive-compulsive disorder have a dysregulated oxidative profile with increased blood oxidative markers.• No global changes in antioxidant defenses in obsessive-compulsive disorder are of remark thus suggesting that oxidative stress is not adequately buffered.• Our results underline the systemic impact of obsessive-compulsive disorder and should motivate the development of future studies in order to better understand this association. Considerations• Most studies did not provide measurements of oxidative and nitrosative stress markers according to pertinent demographic and clinical characteristics thus impairing relevant sensitivity analyses that would have allowed to assess the potential impact of these factors in the results.• The limited number of studies, their moderate quality and heterogeneity, and the evidence for publication bias prevent more robust conclusions.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis

Maia

Oliveira

Lajnef

et al. 2019

Acta Psychiatr Scand

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“…In other words, patients who showed improvements of OCD symptoms had lower values of NO and peroxynitrite in their sera. In other studies comparing the NO levels of patients with OCD with healthy controls, elevated levels were seen in patients as well [13]. …”

Section: Discussionmentioning

confidence: 99%

Changes of Nitric Oxide and Peroxynitrite Serum Levels during Drug Therapy in Patients with Obsessive-Compulsive Disorder

Kouti

Sayyah

Mosallanezhad

et al. 2016

Advances in Medicine

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Objectives. Some studies have shown that increased nitric oxide (NO) concentrations may be associated with obsessive-compulsive disorder (OCD). In a few animal researches, enhanced synthesis of NO had reversed the effect of selective serotonin reuptake inhibitors (SSRIs). The present study tries to find the effect of treatment with SSRIs on NO serum levels and its product peroxynitrite. Patients and Methods. Patients diagnosed with OCD who are candidates of receiving SSRIs entered this study. Two blood samples were taken from subjects, prior to drug therapy and after the patients had shown some improvements due to their regimen. Serum NO and peroxynitrite levels were measured and their correlation with SSRI use was assessed. Results. 31 patients completed this study. Mean concentrations of NO and peroxynitrite prior to drug therapy were 28.63 ± 16.9 and 5.73 ± 2.5 μmol/L, respectively. These values were 18.87 ± 7.55 and 2.15 ± 0.94 μmol/L at the second blood test. With p values < 0.05, these differences were considered significant. Conclusion. Patients, who showed improvement of OCD symptoms after a mean duration of SSRI monotherapy of 3.531 ± 0.64 months, had lower values of NO and peroxynitrite in their sera compared to their levels prior to therapy. Such results can be helpful in finding a predictive factor of response to therapy and augmentation therapy with future drugs that target NO synthesis.

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“…2 ), a stable marker of NO, that were positively correlated with YBOCS scores (Atmaca et al, 2005). Similarly, Yilmaz et al (2016) investigated variations in the levels of NO, asymmetric dimethyl arginine, symmetric dimethyl arginine, and L-arginine levels in patients with OCD. The investigators found that although NO levels were increased, albeit narrowly missing statistical significance, patients with OCD had significantly lower levels of asymmetric dimethyl arginine, symmetric dimethyl arginine, and L-arginine compared with the controls (Yilmaz et al, 2016).…”

Section: B Probing the Role Of Other Endogenous Processes In Obsessive-compulsive Disordermentioning

confidence: 99%

The Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap

et al. 2019

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Servier and has received research funding from Servier and Lundbeck. Except for income from the primary employer and research funding to B.H.H. from the above-mentioned organizations and agencies, no financial support or compensation has been received from any individual or corporate entity over the past 3 years for research or professional services, and there are no personal financial holdings that could be perceived as constituting a potential conflict of interest.

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Levels of nitric oxide, asymmetric dimethyl arginine, symmetric dimethyl arginine,and L-arginine in patients with obsessive-compulsive disorder

Abstract: We found a significant decrease in ADMA, SDMA, and L-arginine as NO inhibitors between the groups, possibly because of an increase in NO. However, the insignificant increase in NO suggests that ADMA, SDMA, and L-arginine play direct and potentially important roles in OCD biology.

Cited by 10 publications

References 57 publications

Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis

Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis

Changes of Nitric Oxide and Peroxynitrite Serum Levels during Drug Therapy in Patients with Obsessive-Compulsive Disorder

The Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap

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