Levels of Plasma N-terminal Pro-brain Natriuretic Peptide and D‑dimer on the Prognosis of Patients with Acute Cerebral Infarction

Abstract

Objective:To investigate the effects of levels of D-dimer and N-terminal pro-brain natriuretic peptide (NT-pro BNP) on the prognosis of patients with acute cerebral infarction.Methods:One hundred and twenty-four patients with acute cerebral infarction who were admitted to the hospital between July 2014 and July 2016 were selected as the observation group; 100 normal people who had health examination in the center of physical examination of our hospital were selected as the control group. The levels of D-dimer and NT-pro BNP of the two groups were observed; the correlation between the levels of plasma NT-pro BNP and D-dimer and area of cerebral infarction, complications and death condition of the observation group was investigated.Results:The levels of D-dimer and NT-pro BNP of the observation group were much higher than those of the control group, and the difference was statistically significant (P<0.05). The levels of D-dimer and NT-pro BNP of the observation group were significantly higher than those of the control group, and the difference had statistical significance (P<0.05). The levels of plasma NT-pro BNP and D-dimer of the patients with disturbance of consciousness and high blood pressure were apparently higher than those with no disturbance of consciousness and normal blood pressure, and there was a statistically significant difference (P<0.05). The patients were followed up for half a year. The levels of D-dimer and NT-pro BNP of the dead patients were much higher than those of the survived patients on admission.Conclusion:The levels of plasma NT-pro BNP and D-dimer can reflect the disease condition and prognosis of patients with acute cerebral infarction. Higher levels of NT-pro BNP and D-dimer indicates poorer prognosis. This work can provide a guidance for the clinical treatment of acute cerebral infarction.

Brain–Heart Axis and Biomarkers of Cardiac Damage and Dysfunction after Stroke: A Systematic Review and Meta-Analysis

“…Compared with the control group, the level of NT-proBNP in the acute ischemic stroke group was higher (WMD = 1600.92, 95% CI = 607.00-2594.84, p = 0.002, I 2 = 99%, p-value of heterogeneity <0.00001). Additionally, a significant difference in NT-proBNP was found between patients in the 2018 [9] proBNP infarction 3). We believe that this result was found due to the small number of articles studied.…”

“…(3) exposure: (f) ascertainment of exposure, (g) the same method of ascertainment for cases and controls, and (h) the non-response rate. [9] ☆ ☆ ☆ ☆ ☆ ☆ ☆ 7…”

“…Cardiac troponin (cTn), the brain natriuretic peptide (BNP), and the N-terminal pro-brain natriuretic peptide (NT-proBNP) are well-known biomarkers of cardiovascular disease [9][10][11][12][13]. As Int.…”

“…Compared with the control group, the level of NT-proBNP in the acute ischemic str [12] 2018 [9] proBNP infarction NT-proBNP, N-terminal fragment of B-type natriuretic peptide; cTnI, cardiac troponin I; BNP, B-type natriuretic peptide; cTnT, cardiac troponin T; -, information not available; SAH, subarachnoid hemorrhage. A maximum of two stars can be allotted in this category, one for study controls for the experimental and control groups, the other for a blood collection time of <24 h.…”

Correlation between the imaging manifestations of cerebellar infarction and the clinical characteristics of patients: a retrospective analysis

“…The increase of Ddimer suggests that it is related to thrombotic diseases caused, and it illustrates the enhancement of brinolytic activity. Existing studies generally support that the increase of D-dimer is a risk factor for cerebral infarction, and it has predictive signi cance for the course of the disease [19][20][21]. Studies have shown that cholesterol carried by LDL is prone to accumulate on the walls of blood vessels and arteries, forming unstable soft plaques, which blocks the cerebral artery and causes a cerebral infarction [22][23][24].…”