Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis

Duruel, Onurcem; Berker, Ezel; Özler, Cansu Özşin; Gharibzadeh-Hızal, Mina; Gürpınar, Öznur; Eryılmaz-Polat, Sanem; Ataman-Duruel, Emel Tuğba; Tan, Çağman; Karabulut, Erdem; Tekçiçek, Meryem; Eser, Özgen Köseoğlu; Ki̇per, Nural; Tezcan, İlhan

doi:10.1016/j.cyto.2020.154987

Cited by 8 publications

(5 citation statements)

References 40 publications

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“…It would be useful for monitoring the signs of local environment (saliva and gingival crevicular fluid) of the disease CF and might be useful for reflecting the respiratory status of the patients. Duruel et al 32 reported increased proinflammatory and decreased anti‐inflammatory cytokine levels in gingival crevicular fluid samples and detected Pa in plaque samples from CF patients. Livnat et al 14 reported the changes found in whole saliva (including in its antioxidant composition) may reflect the respiratory system status as well.…”

Section: Discussionmentioning

confidence: 99%

Dental caries and associated salivary biomarkers in patients with cystic fibrosis

Özler

Duruel

Pınar

et al. 2022

Pediatric Pulmonology

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Purpose: To evaluate the caries status of the Cystic fibrosis (CF) children and adolescents with the comparation of some biochemical markers, secretoryimmunoglobulin-A (sIgA), and antimicrobial peptides in the saliva. Methods:In this cross-sectional descriptive study, the approval Ethics Board was obtained. Unstimulated saliva samples were collected from CF and healthy control children (non-CF) patients. Both groups underwent the same dental and periodontal evaluation scheme of the assessment. Human beta defensin (HBD1), human alpha defensin (HNP-1), cathelicidin (LL-37), sIgA in saliva were evaluated by enzymelinked immunoassay method. A general biochemical analysis was performed.Statistical analysis was performed by using Statistical Package for the Social Sciences Version 20.0 (SPSS Inc.).Results: A total of 21 (9 male, 12 female) CF and 23 (11 male, 12 female) control patients were participated with the mean age of 10.17 ± 3.38 and 9.52 ± 2.15 years, respectively. In control children, DMFT/S (decayed-missing-filled-tooth/surface-inpermanent-dentition), dmft/s (decayed-missing-filled-tooth/surface-in-primarydentition) values were higher; DT (decayed-tooth in permanent dentition), ft (filled-tooth in primary dentition) and plaque index values were statistically significantly higher (p = 0.042, p = 0.005, p = 0.038, respectively) than CF patients. Bicarbonate was higher in control group; sodium, chloride, and total protein were higher in CF group; magnesium, calcium and phosphate levels were similar in each group (p > 0.05). Alpha and beta defensin-1 levels in control group was statistically significantly higher (p = 0.037 and p = 0.020, respectively), while LL37 and sIgA were not statistically significantly higher (p > 0.05) than CF group.Conclusions: Children with CF had lower caries in permanent teeth, filling in primary teeth, and an altered salivary biomarker profile, especially in HNB1, HNP1. Therefore, it is important to conduct periodic oral-dental controls among CF patients during their childhood.

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Section: Discussionmentioning

confidence: 99%

Dental caries and associated salivary biomarkers in patients with cystic fibrosis

Özler

Duruel

Pınar

et al. 2022

Pediatric Pulmonology

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“…Nevertheless, when the host pro-inflammatory response overwhelms host immunoregulatory cell responses, cytokine storms may result. Underlying pathophysiological mechanisms for imbalances between pro-inflammatory and anti-inflammatory mechanisms include inflammatory cell infiltration with inhibition of regulatory cell function, as well as high-level expression of pro-inflammatory cytokines that overwhelms low-level expression of anti-inflammatory cytokines [ 50 , 51 ]. For example, levels of various pro-inflammatory cytokines in serum and bronchoalveolar lavage fluid samples obtained from cystic fibrosis patients were significantly greater than corresponding levels in controls [ 50 , 52 ].…”

Section: Pathophysiological Mechanisms Of Cytokine Stormsmentioning

confidence: 99%

“…Underlying pathophysiological mechanisms for imbalances between pro-inflammatory and anti-inflammatory mechanisms include inflammatory cell infiltration with inhibition of regulatory cell function, as well as high-level expression of pro-inflammatory cytokines that overwhelms low-level expression of anti-inflammatory cytokines [ 50 , 51 ]. For example, levels of various pro-inflammatory cytokines in serum and bronchoalveolar lavage fluid samples obtained from cystic fibrosis patients were significantly greater than corresponding levels in controls [ 50 , 52 ]. Due to the predominantly pro-inflammatory response in cystic fibrosis patients, more and more neutrophils are induced to migrate to the lungs, where the resulting neutrophilic infiltration induces lung damage.…”

Section: Pathophysiological Mechanisms Of Cytokine Stormsmentioning

confidence: 99%

“…Due to the predominantly pro-inflammatory response in cystic fibrosis patients, more and more neutrophils are induced to migrate to the lungs, where the resulting neutrophilic infiltration induces lung damage. In addition, cystic fibrosis patients have been shown to produce decreased levels of anti-inflammatory cytokines, while their Treg cells exhibited lower activity than Treg cells of healthy controls [ 50 , 52 ]. Based on the fact that CRS involves cytokine release, researchers generally agree that immune cells and other types of cells drive CRS-associated processes.…”

Section: Pathophysiological Mechanisms Of Cytokine Stormsmentioning

confidence: 99%

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Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

Tang

Dong

et al. 2021

IJMS

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Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, “multi-omics” immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.

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“…However, data concerning the late-onset periodontitis in CF patients are inconclusive [73] due to fact that the life expectancy of CF patients is below 50 years, and this period is too short for the development of late-onset periodontitis. However, gingivitis, the precursor of late-onset periodontitis, is significantly lower in adult CF patients as compared to healthy controls [73,74], and the periodontal risk is at a low level [75]. Particularly, aggregated NETs (aggNETs) [18] have also been reported [32] in purulent gingival crevicular fluid, but the final stage of bicarbonate-induced NETosis [72] has never been reported, probably due to the short dwelling of PMNs within the gingival periodontal crevice.…”

Section: Net Formation and Aggregation In Late-onset Periodontitismentioning

confidence: 99%

NETs Are Double-Edged Swords with the Potential to Aggravate or Resolve Periodontal Inflammation

Vitkov

Minnich

Knopf

et al. 2020

Cells

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Periodontitis is a general term for diseases characterised by inflammatory destruction of tooth-supporting tissues, gradual destruction of the marginal periodontal ligament and resorption of alveolar bone. Early-onset periodontitis is due to disturbed neutrophil extracellular trap (NET) formation and clearance. Indeed, mutations that inactivate the cysteine proteases cathepsin C result in the massive periodontal damage seen in patients with deficient NET formation. In contrast, exaggerated NET formation due to polymorphonuclear neutrophil (PMN) hyper-responsiveness drives the pathology of late-onset periodontitis by damaging and ulcerating the gingival epithelium and retarding epithelial healing. Despite the gingival regeneration, periodontitis progression ends with almost complete loss of the periodontal ligament and subsequent tooth loss. Thus, NETs help to maintain periodontal health, and their dysregulation, either insufficiency or surplus, causes heavy periodontal pathology and edentulism.

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Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis

Cited by 8 publications

References 40 publications

Dental caries and associated salivary biomarkers in patients with cystic fibrosis

Dental caries and associated salivary biomarkers in patients with cystic fibrosis

Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

NETs Are Double-Edged Swords with the Potential to Aggravate or Resolve Periodontal Inflammation

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