Levels of serum trace elements in patients with primary open-angle glaucoma

Fick, Alexander; Jünemann, Anselm; Michalke, Bernhard; Lucio, Marianna; Hohberger, Bettina

doi:10.1016/j.jtemb.2019.02.006

Cited by 20 publications

(11 citation statements)

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“…Yet, most of patients with glaucoma show a disease progression despite optimal conservative and surgical IOP lowering therapies (5). Thus, several other factors contribute to its multifactorial pathogenesis (e.g., oxidative stress, vascular dysregulation) (20, 21).…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies Activating the β2-Adrenergic Receptor Characterize Patients With Primary and Secondary Glaucoma

et al. 2019

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Recently, agonistic autoantibodies (agAAb) activating the β2-adrenergic receptor were detected in primary open-angle glaucoma (POAG) or ocular hypertension (OHT) patients and were linked to intraocular pressure (IOP) (1). The aim of the present study was to quantify β2-agAAb in the sera of glaucoma suspects and patients with primary and secondary glaucoma. Patients with OHT (n = 33), pre-perimetric POAG (pre-POAG; n = 11), POAG (n = 28), and 11 secondary OAG (SOAG) underwent ophthalmological examinations including examinations with Octopus G1 perimetry and morphometry. Twenty-five healthy individuals served as controls. Serum-derived IgG samples were analyzed for β2-agAAb using a functional bioassay. The beat-rate-increase of spontaneously beating cultured neonatal rat cardiomyocytes was monitored with 1.6 beats/15 s as cut-off. None of the sera of normal subjects showed β2-agAAb. In POAG or OHT patients increased beating rates of 4.1 ± 2.2 beats/15 s, and 3.7 ± 2.8 beats/15 s were detected (p > 0.05). Glaucoma patients with (POAG) and without perimetric (pre-POAG) defects did not differ (pre-POAG 4.4 ± 2.6 beats/15 s, POAG 4.1 ± 2.0 beats/15 s, p > 0.05). Patients with SOAG yielded mean beating rates of 4.7 ± 1.7 beats/15 s (p > 0.05). β2-agAAb were seen in 73% of OHT, 82% of pre-POAG, 82% of POAG, and 91% SOAG patients (p < 0.001). Clinical data did not correlate with beating rate (p > 0.05). The robust β2-agAAb seropositivity in patients with OHT, pre-POAG, POAG, and SOAG suggest a primary common role for β2-agAAb starting early in glaucoma pathophysiology and turned out to be a novel marker identifying all patients with increased IOP independent of glaucoma stage and entity.

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Section: Discussionmentioning

confidence: 99%

Autoantibodies Activating the β2-Adrenergic Receptor Characterize Patients With Primary and Secondary Glaucoma

et al. 2019

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“…Thus, it is general accepted that several other factors are involved in the complex multifactorial pathophysiology of glaucoma. In addition to vascular dysregulation (2), oxidative stress (3)(4)(5), and abnormalities of the lamina cribrosa (6) and the trabecular meshwork (7), the involvement of autoimmune mechanisms (8)(9)(10) are seen as risk factors.…”

Section: Introductionmentioning

confidence: 99%

Agonistic β2-Adrenergic Receptor Autoantibodies Characterize the Aqueous Humor of Patients With Primary and Secondary Open-Angle Glaucoma

et al. 2021

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PurposeAgonistic β2-adrenergic receptor autoantibodies (β2-agAAbs) were recently observed in sera of patients with ocular hypertension (OHT), primary (POAG), and secondary open-angle glaucoma (SOAG), yet not in healthy controls (HCs). It was the aim of the present study to investigate the presence of β2-agAAb in aqueous humor (AH) samples of OAG patients and to correlate these with the corresponding β2-agAAb serum data.Material and MethodsThirty-nine patients (21 male, 18 female) were recruited from the Department of Ophthalmology, University of Erlangen-Nürnberg: twenty-one POAG, 18 SOAG. Aqueous humor samples were collected during minimal invasive glaucoma surgery. Serum and AH samples were analyzed for β2-agAAb by a bioassay quantifying the beating rate of cultured cardiomyocyte (cut-off: 2 U).ResultsThirty-six of 39 (92.3%) and 34 of 39 (87.2%) of OAG patients showed a β2-agAAb in their sera and AH samples, respectively. All β2-agAAb AH-positive OAG patients were also seropositive. We also observed a β2-agAAb seropositivity in 95 and 89% of patients with POAG and SOAG, respectively. Beta2-agAAbs were seen in 86% (POAG) and 78% (SOAG) of AH samples. The β2-agAAb adrenergic activity was increased in the AH of patients with POAG (6.5 ± 1.5 U) when compared with those with SOAG (4.1 ± 1.1 U; p = 0.004). Serum β2-agAAb adrenergic activity did not differ between the cohorts [POAG (4.5 ± 1.5 U); SOAG (4.6 ± 2.1 U; p=0.458)]. No correlation of the beating rates were observed between serum and AH samples for group and subgroup analyses.ConclusionThe detection of β2-agAAb in systemic and local circulations supports the hypothesis of a direct functional impact of these agAAbs on ocular G-protein coupled receptors. The high prevalence of β2-agAAb in serum and AH samples of patients with POAG or SOAG suggests a common role of these AAbs in the etiopathogenesis of glaucoma, independent of open-angle glaucoma subtype.

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“…В работе A. Fick и соавт. [43] показана тенденция к снижению по сравнению с нормой уровня Cu в крови пациентов с ПОУГ, в другой работе не выявлено таких различий [44], правда, авторы этих исследований пользовались различными методами микроэлементного анализа. Такие же противоречивые данные получены в отношении содержания Cu во внутриглазной жидкости (ВГЖ): повышение этого показателя при ПОУГ показано в работе [44], а при ПЭГв работе [45]; при этом в работе [46] не выявлено различий в уровне Cu между нормальной ВГЖ и ВГЖ пациентов с ПЭГ.…”

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“…[50]. В то же время другой метод микроэлементного анализа (масс-спектрометрия с индуктивно связанной плазмой) не показал статистически значимых различий в содержании Zn в сыворотке крови пациентов с ПОУГ и в группе контроля [43].…”

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Structural and biomechanical properties and trace elements composition of the corneoscleral eye shell in normal tension glaucoma

Арутюнян

Iomdina

Морозова

et al. 2021

Rossijskij oftalʹmologičeskij žurnal

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The results of comparative studies of the structural and biomechanical features of the corneoscleral eye shell in various clinical forms of glaucoma are presented. The article discusses how the systemic and local imbalance of trace elements that regulate collagen biosynthesis, the formation of cross-links in the connective tissue structures of the sclera, and the hydrodynamics of the intraocular fluid, affect the intraocular pressure level, and thereby the character of the development of glaucomatous lesions in normal tension glaucoma. Modern literature is shown to indicate the prospects for further research in this direction.

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Levels of serum trace elements in patients with primary open-angle glaucoma

Cited by 20 publications

References 43 publications

Autoantibodies Activating the β2-Adrenergic Receptor Characterize Patients With Primary and Secondary Glaucoma

Autoantibodies Activating the β2-Adrenergic Receptor Characterize Patients With Primary and Secondary Glaucoma

Agonistic β2-Adrenergic Receptor Autoantibodies Characterize the Aqueous Humor of Patients With Primary and Secondary Open-Angle Glaucoma

Structural and biomechanical properties and trace elements composition of the corneoscleral eye shell in normal tension glaucoma

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