Levels of Soluble CD40 Ligand and P-Selectin in Nonalcoholic Fatty Liver Disease

Abstract

Nonalcoholic fatty liver disease (NAFLD) is linked to an increased risk of cardiovascular disease. We aimed to research whether the levels of soluble P-selectin (sP-selectin) and soluble CD40 ligand (sCD40L), markers of endothelial function, are altered in subjects with NAFLD having no confounding factors for atherosclerosis. sCD40L, sP-selectin, and high-sensitivity C-reactive protein (hsCRP) levels, and homeostasis model assessment of insulin resistance (HOMA-IR) indexes were measured in 50 NAFLD subjects and 30 healthy controls. sCD40L, sP-selectin, and hsCRP levels were not significantly different between two groups (P = 0.48, 0.51, and 0.34, respectively). Body mass index, waist circumference, and insulin levels and HOMA indexes were significantly higher in subjects with NAFLD (all P < 0.001). The present data show that sCD40L and sP-selectin may not contribute to the accelerated atherogenesis associated with this clinically relevant condition.

Liver Fat Is Associated With Markers of Inflammation and Oxidative Stress in Analysis of Data From the Framingham Heart Study

“…8 Prior studies have shown a similar association between hepatic steatosis and systemic inflammation. 10,14,[23][24][25][26][27][28][29][30][31]33,15,35,58,[16][17][18][19][20][21][22] In smaller studies of specific populations, radiographic hepatic steatosis is positively associated with hs-CRP, IL6, and ICAM1, consistent with our results. 30,58 Small studies also show greater hs-CRP among those with hepatic steatosis and nonalcoholic steatohepatitis (NASH).…”

“…In hospital-based cohorts, several studies observed an association between those with NAFLD or hepatic fibrosis and measures of systemic inflammation. 17,18,[27][28][29][19][20][21][22][23][24][25][26] Prior studies of the association between NAFLD and inflammatory makers have largely been limited by small sample sizes 16,17,[31][32][33]18,20,24,25,[27][28][29][30] or measurement of a single or few inflammatory markers 10,14,35,15,19,21,22,24,25,33,34 , and have predominantly included those with more advanced NAFLD. 23,26,29 The relationship between hepatic steatosis and systemic inflammation among community-dwellers not selected for liver disease has largely been unexplored.…”

The liver and the kidney: two critical organs influencing the atherothrombotic risk in metabolic syndrome

“…Lucero et al showed that NAFLD was associated with the increase of CV biomarkers, such as high sensitivity C-reactive protein (hsCRP), TNF-α, vascular cell adhesion molecule (VCAM), intercellular adhesion molecule (ICAM) (74). The positive association between increased hs-CRP and NAFLD has been reported in both MetS (75) and healthy subjects (33,(76)(77)(78). Indeed, Lizardi-Cervera et al (76) confirmed the independent predictive value of this biomarker on CV risk (OR 5.83, 95% CI 3.07-11.06; p<0.001).…”

Immune Features of Disparate Liver Transplant Outcomes in Female Hispanics With Nonalcoholic Steatohepatitis

“… 34 , 35 However, the major contributor to long-term chronic allograft damage is CD4 + effector T cells, and many of the soluble mediators we found to be increased in female Hispanics with NASH can profoundly impact the function and survival of these cells, such as IL-7, IL-17A, and sCD40L. 36 – 43 Taken together, female Hispanics with NASH have a heightened innate immune response that quickly switches to an adaptive immune response upon transplantation, with the capacity to drive chronic inflammation-induced damage, leading to poorer outcomes.…”