Levels of Soluble Intercellular Adhesion Molecule-1 and Total Sialic Acid in Serum of Patients with Laryngeal Cancer

Akçay, Fatih; Taysı, Seyithan; Uslu, Celil; Doğru, Yusuf Ziya; Gümüştekin, Kenan

doi:10.1093/jjco/hye128

Cited by 16 publications

(19 citation statements)

References 15 publications

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“…Serum Sialic acid is associated with incremental features of the metabolic syndrome. It should be highlighted that elevated serum sialic acid concentrations are not specific for CVD several malignancies compared to controls such as oral cancer [22], intraocular melanoma [23], laryngeal cancer [24], cholangio carcinoma [25] and is elevated in colorectal cancer [26]. Serum total sialic acid levels markedly elevated in alcoholism [27,28] and is significantly elevated in inflammatory diseases such as liver cirrhosis [29].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Sialic acid Levels in Patients with Type 2 Diabetes Mellitus

Mahendran¹,

Kumar²

2013

IOSR-JDMS

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Section: Discussionmentioning

confidence: 99%

Evaluation of Sialic acid Levels in Patients with Type 2 Diabetes Mellitus

Mahendran¹,

Kumar²

2013

IOSR-JDMS

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“…It has been suggested that malignant transformed these cell surface changes may be triggered by specific oncogene activation [3,5,14,15] .…”

Section: Discussionmentioning

confidence: 99%

“…Positive and negative regulation of cell adhesion will influence the process as metastatic cells break away from the primary tumor, enter in the circulation and then adhere to cellular and extracellular matrix elements in particular secondary sites. Some cell adhesion molecules may play a role in infiltrative growth and metastatic process [5,6] .…”

mentioning

confidence: 99%

“…In one study, it has been reported that increased expression of sICAM-1 has been found in small vessels around colon neoplasms. In the literature, circulating forms several adhesion molecules, including E-cadherin, E-selectin and ICAM-1, were reported to be increased in inflammatory and malignant diseases such as malignant melanoma, gastrointestinal cancer, lymphoma, hepatocellular cancer [5,6] . The significance of adhesion molecule shedding is not clear but it may have profound implications for tumor metastasis.…”

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confidence: 99%

“…Serum/ plasma total or bound sialic acid content has been studied in patients with various types of malignancy such as malignant melanoma, lung, prostate, breast, ovary, colon carcinoma. Marked elevation of serum sialic acid concentrations that correlate with the clinical activity of a disease have been documented in such malignancies [5] .…”

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confidence: 99%

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Correlation between the Serum Values of Soluble Intercellular Adhesion Molecule-1 and Total Sialic Acid Levels in Patients with Breast Cancer

et al. 2007

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Background: In this study, we aimed to investigate serum total sialic acid (TSA) and soluble intracellular adhesion molecule-1 (sICAM-1) levels in breast cancer patients to find a correlation with the cancer stage. Methods: The parameters from sera of 61 patients with breast cancer were measured. The concentrations of serum sICAM-1 and TSA were measured in serum samples from 61 patients with breast cancer and 25 healthy control subjects using enzyme-linked immunoassay and thiobarbituric acid method. Results: Mean serum sICAM-1 and TSA levels were significantly higher in the total patient group than in the control group (p < 0.001). Thus, the correlation between TSA and sICAM-1 became more significant in metastatic breast cancer. There were significant positive correlations between TSA and sICAM-1 in stage I+II (r = 0.59, p < 0.05), stage III (r = 0.47, p < 0.05), and stage IV (r = 0.89, p < 0.01), and total patient group (r = 0.56, p < 0.001). Conclusion: SerumsICAM-1 and TSA levels were higher in patients with breast cancer, than that of the control group, and also in the metastatic breast cancer group. Significant correlations between serum sICAM-1 and TSA may reflect the similar function of these molecules as adhesion molecules, and their roles in the carcinogenesis of breast cancer as well as metastasis.

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The Significance of Serum Soluble Intercellular Adhesion Molecule 1 and Transforming Growth Factor α in Patients With Nasopharyngeal Carcinoma

Yu¹,

Dong²,

Zhou³

et al. 2004

Arch Otolaryngol Head Neck Surg

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To determine serum levels of soluble intercellular adhesion molecule 1 (sICAM-1) and transforming growth factor ␣ (TGF-␣) in 51 patients with nasopharyngeal carcinoma before, during, and after radiation therapy (5-year follow-up period). Results: The mean±SD serum levels of the 2 cytokines were found to be higher in patients before radiotherapy (sI-CAM-1, 369.6±123.7 ng/mL; TGF-␣, 36.6±24.6 ng/mL) than after radiotherapy (sICAM-1, 225.9±124.3 ng/mL; TGF-␣, 20.2±22.3 ng/mL) (PϽ.05), and they were significantly higher in patients with recurrence (sICAM-1, 512.5±271.2 ng/mL; TGF-␣, 48.2±23.4 ng/mL) and in those who died (sICAM-1, 542.6±245.4 ng/mL; TGF-␣, 50.2±28.8 ng/mL) than in patients with no recurrence (sICAM-1, 217.9 ± 116.4 ng/mL; TGF-d, 21.5 ± 26.8 ng/mL) and in those who survived (sICAM-1, 209.4±167.2 ng/mL; TGF-␣, 20.4 ± 27.3 ng/mL) (PϽ.05). The increases in serum levels occurred approximately 3 months before relapse. Conclusion: We found that sICAM-1 and TGF-␣ levels are extremely useful markers for predicting illness, recurrence, and survival.

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Levels of Soluble Intercellular Adhesion Molecule-1 and Total Sialic Acid in Serum of Patients with Laryngeal Cancer

Abstract: These data reveal that the significant correlations between sICAM-1 and TSA in laryngeal cancer, more prominent at advanced stage, might reflect the similar nature of these molecules, which function as adhesion molecules.

Cited by 16 publications

References 15 publications

Evaluation of Sialic acid Levels in Patients with Type 2 Diabetes Mellitus

Evaluation of Sialic acid Levels in Patients with Type 2 Diabetes Mellitus

Correlation between the Serum Values of Soluble Intercellular Adhesion Molecule-1 and Total Sialic Acid Levels in Patients with Breast Cancer

The Significance of Serum Soluble Intercellular Adhesion Molecule 1 and Transforming Growth Factor α in Patients With Nasopharyngeal Carcinoma

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