Levels of systemic inflammation response index are correlated with tumor-associated bacteria in colorectal cancer

Abstract

The relationship between systemic inflammation and tumor-associated bacteria is largely unknown in colorectal cancer (CRC). The primary aim of this study was to investigate the prognostic effects of the systemic inflammation response index (SIRI) on the survival outcomes of CRC patients who experienced surgical therapy, and the second aim was to reveal the potential association between SIRI levels and tumor-associated bacteria in CRC. We recruited a cohort of 298 CRC patients who experienced surgical resection in Wuhan Union Hospital. These patients were assigned to the low and high groups based on the cut-off value of SIRI. We utilized 1:1 propensity score matching (PSM) to reduce the potential confounding factors between the low SIRI group (N = 83) and the high SIRI group (N = 83). The total DNA of 166 paraffin-embedded tumor tissues and 24 frozen tumor tissues was extracted and amplified, and 16 S rRNA sequencing was employed to uncover the composition of microbiota between low and high SIRI groups. Survival analysis uncovered that the high SIRI cohort exhibited significantly shorter overall and disease-free survival time than low SIRI companions after PSM. The ROC analyses showed that the prediction abilities of SIRI were much higher than other serum inflammatory biomarkers for survival outcomes. The microbial richness and diversity in the low SIRI group were remarkably higher than those in the high SIRI group. At the phylum level, we found that Proteobacteria, Synergistetes, WPS-2, Thermil, Fusobacteria were enriched in the high SIRI group. Cupriavidus, Thermus, Ochrobactrum, Cupriavidus, Acidovorax were enriched in the high SIRI group at the genus level. 16 S rRNA based on frozen samples also obtained similar results. SIRI is a promising and novel prognostic biomarker among CRC sufferers who underwent surgical removal. There existed significant differences in the diversity and compositions of tumor-associated bacteria between the low and high SIRI groups.

High preoperative CEA and Systemic Inflammation Response Index(C-SIRI) Predict Unfavorable Survival of Resectable Colorectal Cancer

“…Subsequent studies have affirmed the association of SIRI with survival in patients with liver, gastric, nasopharyngeal, and breast cancers [19][20][21]. Moreover, Cao et al found that high preoperative SIRI was significantly associated with poorer OS and DFS of CRC patients, and predictive ability for the survival of CRC patients was superior to other inflammatory biomarkers, such as PLR, NLR, and SII [14]. However, to date, However, to date, multi-center data still need to confirm its relationship with CRC patients' survival adequately.…”

“…The systemic inflammation response index (SIRI) was established based on neutrophils, monocyte and lymphocyte. To date, the prognostic value of SIRI has been confirmed for various malignancies, such as pancreatic, cervical and gastric cancers, with limited evidence indicating a significant association with survival outcomes in CRC patients [11][12][13][14]. In addition, carcinoembryonic antigen (CEA) is a common tool used to evaluate the prognosis of CRC, and high preoperative CEA levels predict poor disease-free survival (DFS), overall survival (OS) and increased risk of recurrence and metastasis, as shown in earlier studies [15][16].…”

Ascitic microbiota alteration is associated with portal vein tumor thrombosis occurrence and prognosis in hepatocellular carcinoma

“…Some high-impact studies have collected FFPE as experimental samples to explore the relationship between tumor microbiota and cancer development, providing further support for the reliability of our approach and results ( 10 ). Cao et al ( 11 ) collected 166 paraffin-embedded tumor tissues and 24 frozen tumor tissues to investigate the prognostic effects of the systemic inflammation response index on the survival of colorectal cancer patients. Similar results were obtained in 16S rRNA based on the two different samples.…”

Should we consider Systemic Inflammatory Response Index (SIRI) as a new diagnostic marker for rectal cancer?

“…There are a few studies that have discussed the effects of SIRI on colorectal cancer patient’s prognosis. Cao et al evaluated the correlation of SIRI with tumor-associated bacteria and the prognosis of colorectal cancer patients [ 25 ]. They reported that SIRI had a superior predictive performance than the other inflammation-related markers, such as NLR, PLR, and LMR.…”