Levels of Testosterone and Luteinizing Hormone in Plasma Samples Taken at 10-Minute Intervals in Normal Men

Murray, M. A. F.; Corker, C. S.

doi:10.1677/joe.0.0560157

Cited by 62 publications

(23 citation statements)

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“…The absence of a consistent temporal relationship between LH and T secretion in sexually mature young men in this study as well as in the adult men studied by others (39,40) is puzzling. It is possible that with advancing sexual maturation, the sleep-related pubertal LH-T secretory program matures or is modified to become in part governed by feedback influences.…”

Section: Resultscontrasting

confidence: 74%

Human Puberty SIMULTANEOUS AUGMENTED SECRETION OF LUTEINIZING HORMONE AND TESTOSTERONE DURING SLEEP

Boyar¹,

Rosenfeld²,

Kapen³

et al. 1974

J. Clin. Invest.

305

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A B S T R A C T Plasma luteinizing hormone (LH) and testosterone (T) were measured by radioimmunoassay in nine pubertal boys and three sexually mature young men at 20-min intervals for 24 h. Plasma LH and T were also measured in one boy during a delayed sleep onset study. Polygraphic monitoring was carried out to identify precisely sleep onset, wakefulness, and specific sleep stages. In all nine pubertal boys the plasma T concentration fluctuated and was significantly higher during normal nocturnal sleep as compared to daytime waking. This increased T secretion during sleep was temporally linked to the characteristic pubertal sleep augmentation of LH secretion. To define further the relationship of this increased T secretion to sleep, plasma LH and T were also measured in three of the pubertal boys after acute (1-day) reversal of the sleepwake cycle. One of these boys was also studied after 3 days of sleep-wake cycle reversal. The results of these studies showed that plasma T was now augmented during the reversed daytime sleep period; the mean T concentrations during this period were significantly higher (P < 0.001) than during nocturnal waking in all four studies. Measurement of plasma LH and T in the three sexually mature young men showed episodic secretion of LH and T during both waking and sleep periods; there was no consistent significant augmentation of LH or T secretion during sleep. This study demonstrates that (a) in normal pubertal boys and sexually mature young men plasma T fluctuates epi-A preliminary portion of this work has been reported as an abstract (1973. J. Clin. Invest. 52: 11a).Received for publication 19 October 1973 and in revised form 26 February 1974. sodically; (b) there is marked augmentation of T secretion during sleep in pubertal boys, which is dependent on increased LH secretion; (c) this pubertal LH-T secretory "program" is dependent on sleep, since it shifts with delayed sleep onset and reversal of the sleep-wake cycle; and (d) this demonstrable tropic effect of LH on T is evident only during puberty, since sexually mature young men fail to show any consistent relationship between LH and T secretion either awake or asleep. INTRODUCTIONRecent use of the combination of plasma sampling at frequent intervals, sensitive and specific radioimmunoassays, and polygraphic recording of sleep has led to a revised perspective of hormone-secretory dynamics. These procedures, employed throughout the complete 24-h sleep-wake cycle, allowed the recognition of the episodic secretion of cortisol (1-3), ACTH (4, 5). luteinizing hormone (LH)1 (6-13) and follicle-stimulating hormone (FSH) (8,11,12) in adult men and women. The polygraphic monitoring of sleep showed the important role of sleep in the secretion of human growth hormone (14-17), human prolactin (18-20), LH and FSH in normal pubertal girls (21-24), and LH in pubertal boys (22,23).

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Section: Resultscontrasting

confidence: 74%

Human Puberty SIMULTANEOUS AUGMENTED SECRETION OF LUTEINIZING HORMONE AND TESTOSTERONE DURING SLEEP

Boyar¹,

Rosenfeld²,

Kapen³

et al. 1974

J. Clin. Invest.

305

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“…T fluctuations in the peripheral blood of monkeys (6,21), rams (4,22), bulls (23), dogs (5), deer (24), rabbits (25), and mice (7) vary in amplitude from 2 to 30 ng/ml, compared with much smaller variations of < 1-3 ng/ml in men (8)(9)(10)(11)(12). We are unaware of any other species in which moment-to-moment changes in testicular vein steroid levels have been studied.…”

Section: Discussionmentioning

confidence: 99%

“…T fluctuations in peripheral blood in men are of low amplitude and occur at irregular intervals (8)(9)(10)(11)(12). In one study, T increments in men were generally preceded by LH rises, but Portions of these data were published in abstract form (Clin.…”

Section: Introductionmentioning

confidence: 99%

Testosterone and estradiol are co-secreted episodically by the human testis.

Winters¹,

Troen²

1986

J. Clin. Invest.

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In spite of a striking pulsatile pattern of luteinizing hormone (LH) secretion, testosterone (T) fluctuations in peripheral blood in normal adult men are irregular and of low amplitude. To determine whether T secretion by the human testis is episodic, T was measured in blood samples drawn at 15-min intervals for 4 h through a catheter placed in the testicular vein of six men with varicocele-associated infertility. Estradiol (E2) concentrations were also determined in each sample. Each subject released testosterone in well-defined pulses. Gonadal vein T levels ranged from 1 to 1,540 ng/ml. Mean (±SE) pulse amplitude was 176±42 ng/ml, with a frequency of 4.0±03 pulses per 4 h. Testicular vein E2 levels ranged from 0.01 to 6.8 ng/ml. E2 secretory episodes were generally coincident with T pulses, and their amplitudes were highly positively correlated (r = 0.90, P < 0.01).These results indicate that T secretion by the adult human testis is pulsatile, and suggest a functional relationship between intermittent LH secretion and normal testicular steroidogenesis in men. The failure to appreciate these fluctuations as hormone pulses in peripheral blood may relate to their absolute amplitude and frequency. The concordance between E2 and T pulses suggests that the Leydig cell, under LH control, is the source of most of the E2 secreted by the adult human testis.

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“…Although several investigators (1,2) have reported intrasubject consistency of testosterone levels when samples are drawn at the same time on different days, recent reports have demonstrated marked fluctuation in subject testosterone levels during a single day and between days (38,39). Doering et al (40) have recently presented data showing cycles in testosterone levels with periods from 8 to 30 days.…”

Section: Discussionmentioning

confidence: 99%

Plasma Testosterone Levels in the Rapist

Rada¹,

Laws²,

Kellner³

1976

Psychosomatic Medicine

169

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Plasma testosterone level was measured in 52 rapists and 12 child molesters who had completed the Buss-Durkee Hostility Inventory, the Megargee Overcontrolled Hostility Scale, and the Michigan Alcoholism Screening Test. The rapists were classified according to the degree of violence during the commission of the rape. The ranges and means of the plasma testosterone level for the rapist and child molester controls were within normal limits. The group of rapists who were judged to be most violent had a significantly higher mean plasma testosterone level than normals, child molesters, and other rapists in this study. Mean Buss-Durkee hostility rating scores for rapists were significantly higher than the mean for normals, but there was no correlation between individual hostility scores and plasma testosterone levels. There was no correlation between age, race, or length of incarceration and plasma testosterone level.

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Levels of Testosterone and Luteinizing Hormone in Plasma Samples Taken at 10-Minute Intervals in Normal Men

Cited by 62 publications

References 0 publications

Human Puberty SIMULTANEOUS AUGMENTED SECRETION OF LUTEINIZING HORMONE AND TESTOSTERONE DURING SLEEP

Human Puberty SIMULTANEOUS AUGMENTED SECRETION OF LUTEINIZING HORMONE AND TESTOSTERONE DURING SLEEP

Testosterone and estradiol are co-secreted episodically by the human testis.

Plasma Testosterone Levels in the Rapist

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