Levels of TGF<i>β</i>1 in gingival crevicular fluid during a 21‐day experimental model of gingivitis

Wright, Helen J.; Chapple, Iain; Matthews, J. B.

doi:10.1034/j.1601-0825.2003.02895.x

Cited by 32 publications

(36 citation statements)

References 29 publications

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“…Compared to healthy subjects, increased TGF-β levels are found in gingival tissues and gingival crevicular fluid (GCF) samples from patients with gingivitis, chronic periodontitis, generalized aggressive periodontitis and peri-implantitis (Buduneli et al 2001;Cornelini et al 2003;Ejeil et al 2003;Gurkan et al 2006;Steinsvoll Halstensen and Schenck 1999;Wright Chapple and Matthews 2003). Genetic polymorphisms in the TGF-β gene have been shown to interfere with the production, secretion or activity of this growth factor (Atilla et al 2006;Awad et al 1998;Li et al 1999) and this has been associated with risk for systemic diseases including cardiovascular diseases and rheumatoid arthritis, which are related to periodontitis in terms of chronic inflammatory processes (Atilla et al 2006;Garcia Henshaw and Krall 2001;Mercado Marshall and Bartold 2003;Sugiura et al 2002).…”

Section: Tgf-β Signaling Pathwaymentioning

confidence: 99%

Beyond Good and Evil in the Oral Cavity: Insights into Host-Microbe Relationships Derived from Transcriptional Profiling of Gingival Cells

2008

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In many instances, the encounter between host and microbial cells can be, through a longstanding evolutionary association, a balanced interaction whereby both cell types co-exist and inflict a minimal degree of harm on each other. In the oral cavity, despite the presence of large numbers of diverse organisms, health is the most frequent status. Disease will only ensue when the host-microbe balance is disrupted on a cellular and molecular level. With the advent of microarrays, it is now possible to monitor the responses of host cells to bacterial challenge in a global scale. However, microarray data are known to be inherently noisy, which is caused in part by their great sensitivity. Hence, we will address a number of important general considerations required to maximize the significance of microarray analysis in order to faithfully depict relevant host-microbe interactions. Several advantages and limitations of microarray analysis that may directly impact the significance of array data are highlighted and discussed. Further, this review revisits and contextualizes recent transcriptional profiles that were originally generated to specifically study intricate cellular interactions between gingival cells and four important plaque microorganisms. This is, to our knowledge, the first report that systematically investigates the cellular responses of a cell line to challenge by 4 different microorganisms. Of particular relevance to the oral cavity, the model bacteria span the entire spectrum of documented pathogenic potential from commensal to opportunistic to overtly pathogenic. These studies provide a molecular basis of the complex and dynamic interaction between the oral microflora and its host, which may lead, in the long run, to the development of novel, rational and practical therapeutic, prophylactic and diagnostic applications.

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Section: Tgf-β Signaling Pathwaymentioning

confidence: 99%

Beyond Good and Evil in the Oral Cavity: Insights into Host-Microbe Relationships Derived from Transcriptional Profiling of Gingival Cells

2008

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“…Previous studies also reported increased in GCF volume both with the severity of gingival inflammation and periodontitis 11,[13][14][15] . Jepsen et al 35) , Wright et al 36) and Hatipoglu et al 37) reported increased in GCF volume in experimental gingivitis model and suggested that this increased GCF volume reflect the level of gingival inflammation. Uttio 16) reported that in periodontitis, increased in GCF volume was associated with increased in probing pocket depth and deeper pockets were associated with higher GCF volume.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Impact of the Clinical Periodontal Status on Volumetric Features of Gingival Crevicular Fluid by using Periotron<sup>®</sup> 8000

Sehdev

Ganji

Bhongade

et al. 2017

J. Hard Tissue Biology.

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Clinical periodontal status is among the major determinants of the volumetric features of GCF. Previous studies have shown that probing depth, presence/severity of gingival and periodontal inflammation affect the biodynamics of GCF. The aim of the present study was to evaluate the impact of the clinical periodontal status on volumetric features of gingival crevicular fluid. Thirty-six patients were equally divided into healthy group, gingivitis group and periodontitis group. Clinical periodontal status was assessed by recording: papillary bleeding index, probing pocket depth and clinical attachment level. Gingival crevicular fluid (GCF) samples were obtained from 4 sites in each patient. The mean volume of GCF was determined in each group for comparison. Further in periodontitis group, GCF samples were also collected from healthy sites, gingivitis sites and periodontitis sites. Mean GCF volume recorded by using Periotron® 8000 in healthy gingival group, gingivitis group and periodontitis group were: 0.04, 0.09, 0.78 µl respectively. There was increase in GCF volume in a diseased related pattern, healthy gingival group < gingivitis group < periodontitis group. In periodontitis group, the sites with healthy gingiva showed significantly higher GCF volume than healthy gingival group (0.11µl Vs 0.04µl), similarly, the sites with gingivitis in periodontitis group also showed significantly higher GCF volume than gingivitis group (0.32µl Vs 0.11µl). The present study suggests that the volumetric analysis of GCF could be sensitive and reliable indicator of periodontal health. The ability of GCF volume as a chair side measure to differentiate healthy sites from sites with mild disease within the same mouth is considered noteworthy.

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“…Wright e cols. relatam que o TGFβ (tumor growth factor beta) estimula a produção de componentes da matriz extracelular por fibroblastos, função essencial para a regeneração dos tecidos periodontais (27). A PGE 2 induz a vasodilatação, aumento da permeabilidade vascular e estimula a síntese de metaloproteinases (degradam a matriz extracelular tecidual), levando à destruição de tecido conjuntivo.…”

Section: Secreção De Citocinas E Mediadores Inflamatórios Versus Lipounclassified

Mecanismos patogênicos da doença periodontal associada ao diabetes melito

Alves

Andion

Brandão

et al. 2007

Arq Bras Endocrinol Metab

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RESUMOObjetivo: Revisão sistemática do conhecimento atual sobre a associação entre diabetes melito (DM) e doença periodontal (DP) com ênfase na sua fisiopatogenia. Fonte de dados: Pesquisa bibliográfica, nos últimos cinco anos, através dos bancos de dados MEDLINE e LILACS, usando as palavras-chaves "diabetes mellitus", "periodontal disease" e "periodontitis". Síntese dos dados: Os tecidos periodontais são as estruturas bucais mais afetadas pelo DM. O DM predispõe ao desenvolvimento da DP, a qual leva ao descontrole glicêmico, o que ressalta a importância da relação bidirecional entre essas duas doenças. Vários mecanismos estão envolvidos na fisiopatologia da DP associada ao DM: produção de produtos de glicosilação avançada, deficiente resposta imune, herança de determinados polimorfismos genéticos, alterações dos vasos sanguíneos, tecido conjuntivo e composição salivar. Na fase inicial predominam a gengivite e periodontite. Se não detectados precocemente, esses problemas podem evoluir para doença periodontal avançada. Puberdade, maior duração da doença, mau controle metabólico e higiene bucal inadequada são fatores que contribuem para progressão e agressividade da DP. Conclusão: O melhor conhecimento dos mecanismos envolvidos na fisiopatogenia da DP associada ao DM auxiliará na instituição de medidas preventivas e terapêuticas precoces. É importante que médicos e dentistas orientem os pacientes com DM sobre a necessidade de bom controle glicêmico e higiene bucal adequada para minimizar os riscos de doença periodontal. Objective: Systematic review of present knowledge about the association between diabetes mellitus (DM) and periodontal disease (PD) with emphasis on their physiopathogenesis. Data sources: Bibliographic search through MEDLINE and LILACS databases, in the last five years, using the following descriptors: "diabetes mellitus", "periodontal disease", and "periodontitis". Summary of data: Periodontal tissues are the oral structures most affected by DM. DM predisposes to the development of PD, which leads to loss of glycemic control, which emphasizes the importance of the two-way relationship between these two diseases. Several mechanisms are involved in the physiopathology of PD associated with DM: production of advanced glycosilation products, deficient immune response, inheritance of certain genetic polymorphisms, alterations in blood vessels, conjunctive tissue and salivary composition. In the initial phase, gingivitis and periodontitis predominate. If not detected early, these problems can develop into advanced periodontal disease. Puberty, with its hormonal alterations, longer duration of the disease, poor metabolic control and inadequate oral hygiene are factors that contribute to PD progression and aggressiveness. Conclusion: Better knowledge about the mechanisms involved in the physiopathogenesis of PD associated with DM would help to institute early preventive and therapeutic measures. It is important for doctors and dentists to instruct their patients with DM about the need for good glycemic c...

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Levels of TGFβ1 in gingival crevicular fluid during a 21‐day experimental model of gingivitis

Abstract: The data indicate that GCF TGFbeta1 levels increase early in plaque-induced inflammation. Whether the biological consequence of this site-specific increase is pro- or anti-inflammatory in nature remains to be elucidated.

Cited by 32 publications

References 29 publications

Beyond Good and Evil in the Oral Cavity: Insights into Host-Microbe Relationships Derived from Transcriptional Profiling of Gingival Cells

Beyond Good and Evil in the Oral Cavity: Insights into Host-Microbe Relationships Derived from Transcriptional Profiling of Gingival Cells

Evaluation of the Impact of the Clinical Periodontal Status on Volumetric Features of Gingival Crevicular Fluid by using Periotron<sup>®</sup> 8000

Mecanismos patogênicos da doença periodontal associada ao diabetes melito

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