Levels of Th1 and Th2 cytokines in children with post-infectious bronchiolitis obliterans

Costa, Maria L. K.; Stein, Renato T.; Bauer, Moisés Evandro; Jones, Marcus Herbert; Bertotto, Carolina; Pitrez, Paulo Márcio

doi:10.1179/146532805x72403

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…It usually preceded the previous reported risk factors such as hypercapnia and mechanical ventilation (Jouett et al 2015 ; Wilson and Matthay 2014 ), which made it more sensitive than other predictors. The causes and mechanism of development of BO was still unclear (Kim et al 2006 ; Gedik et al 2015 ; Costa et al 2005 ; Mallol et al 2011 ). In order to achieve reliable results, prognostic analysis of BO shall be based on simple disease background.…”

Section: Discussionmentioning

confidence: 99%

Hypoxemia is an independent predictor of bronchiolitis obliterans following respiratory adenoviral infection in children

Jiang

et al. 2016

SpringerPlus

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Bronchiolitis obliterans (BO) is an uncommon and severe sequela of chronic obstructive lung disease in children that results from an insult to the lower respiratory tract. Few prognostic factors achieved worldwide acknowledgment. In the present study, we retrospectively collected the children with respiratory adenoviral infection and identified the predictive factors of BO. In the period between Jan 2011 and December 2014, the consecutive in-hospital acute respiratory infection children with positive result for adenovirus were enrolled into the present study. High resolution computerized tomography and clinical symptoms were utilized as the diagnostic technique for BO. Multivariate analysis using a Logistic proportional hazards model was used to test for independent predictors of BO. A total of 544 children were included with 14 (2.57 %) patients developed BO. Compared with children without BO, BO children presented higher LDH (523.5 vs. 348 IU/ml, p = 0.033), lower blood lymphocyte count (2.23 × 109/L vs. 3.24 × 109/L, p = 0.025) and higher incidence of hypoxemia (78.6 vs. 20.8 %, p = 0.000). They presented relatively persistent fever (15.5 vs. 7 days, p = 0.000) and needed longer treatment in hospital (19.5 vs. 7 days, p = 0.000). Concerning treatment, they were given more intravenous γ-globulin (85.7 vs. 36.8 %, p = 0.000), glucocorticoids (78.6 vs. 24.3 %, p = 0.000) and mechanical ventilation (35.7 vs. 5.5 %, p = 0.001). Multiple analyses determined that hypoxemia was the only independent predictor for BO. The present study identified hypoxemia as the independent predictive factor of BO in adenoviral infected children, which was a novel and sensitive predictor for BO.

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