Levels of tissue inhibitor of metalloproteinases 1 in plasma and urine from patients with bladder cancer

Holten-Andersen, Mads Nikolaj; Brünner, Nils; Nielsen, Hans Jørgen; Christensen, Ib Jarle; Sørensen, Nanna Møller; Rasmussen, A.-S. Schrohl; Primdahl, Hanne; Ørntoft, T.

doi:10.5301/jbm.2008.1217

Cited by 60 publications

(90 citation statements)

References 14 publications

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“…Several investigators have reported that TIMP-1 has growth-promoting properties and might also stimulate tumour growth by inhibiting apoptosis (Holten-Andersen et al, 2002). Overexpression of TIMP-1 has been reported in colorectal cancer tissues (Murashige et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis

et al. 2005

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It is generally accepted that most colorectal carcinomas arise in pre-existing adenomas. Morphologically, colorectal adenomas can be divided into two groups, protruded type and flat type. The aim of this study was to clarify relevant alterations of gene expression associated with the early stage of colorectal carcinogenesis. Using cDNA array, we analysed the expression profiles of 550 cancerrelated genes in 36 colorectal adenomas (18 flat-type and 18 protruded-type adenomas) and 14 early invasive carcinomas. Among the 550 genes, we chose 32 genes the average expression levels of which were at least three-fold up-or downregulated in tumour tissues compared with levels in matched normal tissues. A total of 13 and 19 genes were identified as up-and downregulated genes in tumour tissues, respectively. Among the upregulated genes, the average expression levels of E1AF, bone morphogenic protein (BMP)-4, insulin-like growth factor (IGF)-2, inducible nitric oxide synthase (iNOS), tissue inhibitors of metalloproteinase (TIMP)-1, Smad4, and nm23 in tumour tissues were over five times higher than those in matched normal tissues. Colorectal adenomas and early invasive carcinomas were divided into two major clusters by clustering analysis. Moreover, flat-and protruded-type adenomas were divided into two major clusters by clustering analysis. The expression profiles obtained by the cDNA array clearly indicate that colorectal adenomas and early invasive carcinomas have specific expression profiles. Likewise, the gene expression profiles of flat-and protruded-type adenomas are different. These results indicate that molecular classification of early colorectal tumours by a cDNA array is feasible.

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Section: Discussionmentioning

confidence: 99%

Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis

et al. 2005

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“…However, it should also be mentioned that other data have failed to demonstrate a difference in the plasma TIMP-1 levels between primary breast cancer patients and healthy controls (Holten-Andersen et al 2002). Future studies should be directed at validating the potential prognostic value of TIMP-1 measurements in plasma.…”

Section: Discussionmentioning

confidence: 99%

Tissue inhibitor of metalloproteinases-1 in breast cancer

Würtz

Schrohl²,

Sørensen³

et al. 2005

Endocrine Related Cancer

100

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Whether patients diagnosed with primary breast cancer are offered adjuvant systemic therapy following surgical removal of the tumor is based on prognosis. Prognosis is estimated in every patient using established prognostic variables. Unfortunately, when using the currently available prognostic parameters a significant proportion of patients are over-treated. Thus, in order to improve stratification of breast cancer patients, additional prognostic factors need to be identified. Tissue inhibitor of metalloproteinases-1 (TIMP-1) is one of the promising candidates for new prognostic markers in breast cancer, as a number of studies have demonstrated an association between high tumor-tissue levels of TIMP-1 mRNA as well as TIMP-1 protein and a poor prognosis of breast cancer patients. TIMP-1 is a member of the TIMP family, currently comprising four members (TIMP-1-4), and its main function is inhibition of the activity of various matrix metalloproteinases (MMPs). The association between high levels of protease inhibitor and poor prognosis may be somewhat surprising, as proteolytic activity plays a pivotal role in cancer cell invasion and metastasis. However, the recent discovery of other biological functions of TIMP-1 such as growth-stimulating functions, as well as anti-apoptotic and pro-angiogenetic effects, may in part explain this paradox. The purpose of this review is to give an update on the current status of TIMP-1 in breast cancer, emphasizing the prognostic utility of the inhibitor. In addition, the suggested tumor-stimulatory roles of TIMP-1 will be outlined.

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“…We found that combining results from the CEA assay with the anti-TAA assay increased the detection of early-stage colorectal cancer from 21.9% to 65.9% (Table 2). Similarly, a study by HoltenAnderson et al 42 has shown that combining serum CEA and metallopeptidase inhibitor 1 measurements resulted in a 66% detection frequency among early-stage colon cancer patients. Our findings demonstrated that autoantibody signatures may possess potential to supplement other serological markers for improved diagnosis of early-stage colorectal cancer, especially for CEA-negative individuals.…”

Section: Discussionmentioning

confidence: 99%

“…41,42 Overall, we did not Using Chi-square test. 4 Right-sided colon: cecum, ascending colon and hepatic flexure of ascending colon; left-sided colon: splenic flexure of transverse colon, descending colon, rectosigmoid and rectum.…”

Section: Discussionmentioning

confidence: 99%

Multiple serological biomarkers for colorectal cancer detection

Chan

Fan

Kuo

et al. 2010

Intl Journal of Cancer

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The aim of this study was to initiate a survey of human autoantibody responses to a panel of select colorectal tumorassociated antigens identified by previous serological analysis of a cDNA expression library and to subsequently identify multiple serological biomarkers for the detection of colorectal cancer. For screening of autoantibodies against colorectal tumor-associated antigens, sera from 94 colorectal cancer patients and 54 normal controls were analyzed by enzyme-linked immunosorbent assay using recombinant rCCCAP, rHDAC5, rP53, rNMDAR and rNY-CO-16 proteins as coating antigens. Seropositivity among colorectal cancer patients to the 5 individual coating antigens varied from 18.1% to 35.1%. Seropositivity to any of the 5 coating antigens was 58.5% and combining this analysis with evaluation of serum carcinoembryonic antigen (!5 ng/ml) significantly increased the seropositivity to 77.6%. Seropositivity of early-stage (Dukes' Stages A and B) colorectal cancer patients to CEA was 21.9%, and seropositivity to any of the 5 colorectal cancer-associated antigens was 53.7%, and the combination of these 2 measurements resulted in a higher diagnostic capacity (65.9%) than either marker alone. In conclusion, these results collectively indicated that combined detection of serum autoantibody profiles against our panel of colorectal tumor-associated antigens and the analysis of carcinoembryonic antigen provides a promising diagnostic biomarker for colorectal cancer, particularly among early-stage patients.

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Levels of tissue inhibitor of metalloproteinases 1 in plasma and urine from patients with bladder cancer

Cited by 60 publications

References 14 publications

Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis

Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis

Tissue inhibitor of metalloproteinases-1 in breast cancer

Multiple serological biomarkers for colorectal cancer detection

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